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Chymase and Chymosin – Rumored To Be Synonyms (and a little renin and rennin)

Chymase Alternative name for chymosin [“chymase .” A Dictionary of Food and Nutrition. . Encyclopedia.com. 25 Aug. 2022 https://www.encyclopedia.com]

Mast Cell Chymase and Tryptase and some MMPs

Chymase and tryptase are packaged in secretory granules together with histamine and other mediators in mast cells, which are infiltrated in rheumatoid synovium. Chymase is a chymotrypsin-like proteinase with a broad spectrum of activity against ECM components such as type VI collagen7 and aggrecan. It also activates proMMPs such as proMMP-1, 3, and 9.6 Although prochymase is activated intra-cellularly and stored in the granules, the activity in the granules is limited at low pH and becomes fully active when released extra-cellularly. Tryptase is a trypsin-like proteinase that degrades type VI collagen7 and fibronectin; it also activates proMMP-3.6 [Proteinases and Matrix Degradation, Yasunori Okada, in Kelley and Firestein’s Textbook of Rheumatology (Tenth Edition), 2017]

Chymase at Wikipedia (page last updated March 27, 2022)

Chymosin at Wikipedia (page last updated April 5, 2022)

Not to be confused with renin, an enzyme which takes part in regulation of arterial blood pressure.

Occurrence

Enzymatic reaction

Examples

Listed below are the ruminant Cym gene and corresponding human pseudogene:

Chymosin [Precursor]

X-ray analysis of calf chymosin [Newman M, Safro M, Frazao C, Khan G, Zdanov A, Tickle IJ, et al. (October 1991). “X-ray analyses of aspartic proteinases. IV. Structure and refinement at 2.2 A resolution of bovine chymosin”. Journal of Molecular Biology221 (4): 1295–309. doi:10.1016/0022-2836(91)90934-XPMID 1942052.] Identifiers:
Organism – Bos taurus
Symbol -Cym
Alt. symbols – CPC
Entrez529879
PDB4CMS
UniProtP00794

chymosin pseudogene (human)

Identifiers:

Symbol – CYMP

NCBI gene – 643160

HGNC – 2588

OMIM – 118943

RefSeq – NR_003599

Other data

Locus Chr. 1 p13.3

Recombinant chymosin

Proteasesaspartate proteases (EC 3.4.23)
Enzymes

Rennet gets another page

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