Inborn errors of carbohydrate metabolism

Sucrose, transport
(extracellular)
Disaccharide catabolismCongenital alactasia Sucrose intolerance


Monosaccharide transportGlucose-galactose malabsorption Inborn errors of renal tubular transport (Renal glycosuria) Fructose malabsorption
Hexose â†’ glucoseMonosaccharide catabolismFructose: Essential fructosuria Fructose intolerance
Galactose/galactosemia: GALK deficiency GALT deficiency/GALE deficiency
Glucose â‡„ glycogenGlycogenesis GSD type 0 (glycogen synthase deficiency) GSD type IV (Andersen’s disease, branching enzyme deficiency) Adult polyglucosan body disease (APBD) Glycogenolysis Extralysosomal: GSD type III (Cori’s disease, debranching enzyme deficiency) GSD type VI (Hers’ disease, liver glycogen phosphorylase deficiency) GSD type V (McArdle’s disease, myophosphorylase deficiency) GSD type IX (phosphorylase kinase deficiency) Lysosomal (LSD):GSD type II (Pompe’s disease, glucosidase deficiency)
Glucose â‡„ CACGlycolysis MODY 2/HHF3 GSD type VII (Tarui’s disease, phosphofructokinase deficiency) Triosephosphate isomerase deficiency Pyruvate kinase deficiency Gluconeogenesis PCD Fructose bisphosphatase deficiency GSD type I (von Gierke’s disease, glucose 6-phosphatase deficiency)
Pentose phosphate pathwayGlucose-6-phosphate dehydrogenase deficiency Transaldolase deficiency6-phosphogluconate dehydrogenase deficiency
OtherHyperoxaluria Primary hyperoxaluria Pentosuria Aldolase A deficiency
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