Tabar AI, Acero S, Arregui C, Urdánoz M, Quirce S. Asma y alergia por el colorante carmín [Asthma and allergy due to carmine dye]. An Sist Sanit Navar. 2003;26 Suppl 2:65-73. Spanish. PMID: 13679965.

Abstract

^{Cochineal carmine, or simply carmine (E120), is a red colouring that is obtained from the dried bodies of the female insect Dactylopius coccus Costa (the cochineal insect). We have evaluated the prevalence of sensitization and asthma caused by carmine in a factory using natural colouring, following the diagnosis of two workers with occupational asthma. The accumulated incidence of sensitization and occupational asthma due to carmine in this factory are 48.1% and 18.5% respectively, figures that make the introduction of preventive measures obligatory. Occupational asthma caused by inhaling carmine should be considered as a further example of the capacity of certain protein particles of arthropods (in this case cochineal insects) to act as aeroallergens. Carmine should be added to the list of agents capable of producing occupational asthma, whose mechanism, according to our studies, would be immunological mediated by IgE antibodies in the face of diverse allergens of high molecular weight, which can vary from patient to patient. Nonetheless, given the existence of different components in carmine, it cannot be ruled out that substances of low molecular weight, such as carminic acid, might act as haptenes. Besides, since we are dealing with a colouring that is widely used as a food additive, as a pharmaceutical excipient and in the composition of numerous cosmetics, it is not surprising that allergic reactions can appear both through ingestion and through direct cutaneous contact. We find ourselves facing a new example of an allergen that can act through both inhalation and digestion, giving rise to an allergolical syndrome that can show itself clinically with expressions of both respiratory allergy and alimentary allergy.}

What is a hapten in immunology?

A hapten is a substance that can combine with a specific antibody but lacks antigenicity of its own. Many small molecules of M_r < 1000 such as toxins, drugs and hormones are not capable of invoking immune response when injected directly into animals. They are thus not immunogenic by themselves, and are called haptens.

Hapten – an overview | ScienceDirect Topics

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