P300 interactions (list)

EP300 has been shown to interact with:

• BCL3,
  • B-cell lymphoma 3-encoded protein is a protein that in humans is encoded by the BCL3 gene.
    • Na SY, Choi JE, Kim HJ, Jhun BH, Lee YC, Lee JW (October 1999). “Bcl3, an IkappaB protein, stimulates activating protein-1 transactivation and cellular proliferation”. J. Biol. Chem. 274 (40): 28491–6. doi:10.1074/jbc.274.40.28491. PMID 10497212.
• BRCA1,
  • Breast cancer type 1 susceptibility protein is a protein that in humans is encoded by the BRCA1 gene. Orthologs are common in other vertebrate species, whereas invertebrate genomes may encode a more distantly related gene.
    • Fan S, Ma YX, Wang C, Yuan RQ, Meng Q, Wang JA, Erdos M, Goldberg ID, Webb P, Kushner PJ, Pestell RG, Rosen EM (January 2002). “p300 Modulates the BRCA1 inhibition of estrogen receptor activity”. Cancer Res. 62 (1): 141–51. PMID 11782371.
    • Pao GM, Janknecht R, Ruffner H, Hunter T, Verma IM (February 2000). “CBP/p300 interact with and function as transcriptional coactivators of BRCA1“. Proc. Natl. Acad. Sci. U.S.A. 97 (3): 1020–5. Bibcode:2000PNAS…97.1020P. doi:10.1073/pnas.97.3.1020. PMC 15508. PMID 10655477.
• CDX2,
  • Homeobox protein CDX-2 is a protein that in humans is encoded by the CDX2 gene. The CDX2 protein is a homeobox transcription factor expressed in the nuclei of intestinal epithelial cells, playing an essential role in the development and function of the digestive system. 
    • Hussain MA, Habener JF (October 1999). “Glucagon gene transcription activation mediated by synergistic interactions of pax-6 and cdx-2 with the p300 co-activator”. J. Biol. Chem. 274 (41): 28950–7. doi:10.1074/jbc.274.41.28950. PMID 10506141.
• CEBPB,
  • CCAAT/enhancer-binding protein beta is a protein that in humans is encoded by the CEBPB gene.
    • Mink S, Haenig B, Klempnauer KH (November 1997). “Interaction and functional collaboration of p300 and C/EBPbeta”. Mol. Cell. Biol. 17 (11): 6609–17. doi:10.1128/mcb.17.11.6609. PMC 232514. PMID 9343424
• CITED1,
  • Cbp/p300-interacting transactivator 1 is a protein that in humans is encoded by the CITED1 gene.
    • Yahata T, de Caestecker MP, Lechleider RJ, Andriole S, Roberts AB, Isselbacher KJ, Shioda T (March 2000). “The MSG1 non-DNA-binding transactivator binds to the p300/CBP coactivators, enhancing their functional link to the Smad transcription factors”. J. Biol. Chem. 275 (12): 8825–34. doi:10.1074/jbc.275.12.8825. PMID 10722728.
• CITED2,
  • Cbp/p300-interacting transactivator 2 is a protein that in humans is encoded by the CITED2 gene.
    • Bhattacharya S, Michels CL, Leung MK, Arany ZP, Kung AL, Livingston DM (January 1999). “Functional role of p35srj, a novel p300/CBP binding protein, during transactivation by HIF-1”. Genes Dev. 13 (1): 64–75. doi:10.1101/gad.13.1.64. PMC 316375. PMID 9887100.
    • Bragança J, Eloranta JJ, Bamforth SD, Ibbitt JC, Hurst HC, Bhattacharya S (May 2003). “Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2”. J. Biol. Chem. 278 (18): 16021–9. doi:10.1074/jbc.M208144200. PMID 12586840.
    • Bragança J, Swingler T, Marques FI, Jones T, Eloranta JJ, Hurst HC, Shioda T, Bhattacharya S (March 2002). “Human CREB-binding protein/p300-interacting transactivator with ED-rich tail (CITED) 4, a new member of the CITED family, functions as a co-activator for transcription factor AP-2”. J. Biol. Chem. 277 (10): 8559–65. doi:10.1074/jbc.M110850200. PMID 11744733.
    • Glenn DJ, Maurer RA (December 1999). “MRG1 binds to the LIM domain of Lhx2 and may function as a coactivator to stimulate glycoprotein hormone alpha-subunit gene expression”. J. Biol. Chem. 274 (51): 36159–67. doi:10.1074/jbc.274.51.36159. PMID 10593900.
• DDX5,
  • Probable ATP-dependent RNA helicase DDX5 also known as DEAD box protein 5 or RNA helicase p68 is an enzyme that in humans is encoded by the DDX5 gene.
    • Rossow KL, Janknecht R (January 2003). “Synergism between p68 RNA helicase and the transcriptional coactivators CBP and p300”. Oncogene. 22 (1): 151–6. doi:10.1038/sj.onc.1206067. PMID 12527917.
• DTX1,
  • Protein deltex-1 is a protein that in humans is encoded by the DTX1 gene.
    • Yamamoto N, Yamamoto S, Inagaki F, Kawaichi M, Fukamizu A, Kishi N, Matsuno K, Nakamura K, Weinmaster G, Okano H, Nakafuku M (November 2001). “Role of Deltex-1 as a transcriptional regulator downstream of the Notch receptor”. J. Biol. Chem. 276 (48): 45031–40. doi:10.1074/jbc.M105245200. PMID 11564735.
• EID1,
  • EP300-interacting inhibitor of differentiation 1 is a protein that in humans is encoded by the EID1 gene.
    • Miyake S, Sellers WR, Safran M, Li X, Zhao W, Grossman SR, Gan J, DeCaprio JA, Adams PD, Kaelin WG (December 2000). “Cells degrade a novel inhibitor of differentiation with E1A-like properties upon exiting the cell cycle”. Mol. Cell. Biol. 20 (23): 8889–902. doi:10.1128/mcb.20.23.8889-8902.2000. PMC 86544. PMID 11073989.
    • MacLellan WR, Xiao G, Abdellatif M, Schneider MD (December 2000). “A novel Rb- and p300-binding protein inhibits transactivation by MyoD”. Mol. Cell. Biol. 20 (23): 8903–15. doi:10.1128/mcb.20.23.8903-8915.2000. PMC 86545. PMID 11073990.
• ELK1,
  • ETS Like-1 protein Elk-1 is a protein that in humans is encoded by the ELK1. Elk-1 functions as a transcription activator. It is classified as a ternary complex factor (TCF), a subclass of the ETS family
    • Li QJ, Yang SH, Maeda Y, Sladek FM, Sharrocks AD, Martins-Green M (January 2003). “MAP kinase phosphorylation-dependent activation of Elk-1 leads to activation of the co-activator p300”. EMBO J. 22 (2): 281–91. doi:10.1093/emboj/cdg028. PMC 140103. PMID 12514134.
• ESR1,
  • Estrogen receptor alpha (ERα), also known as NR3A1, is one of two main types of estrogen receptor, a nuclear receptor that is activated by the sex hormone estrogen. In humans, ERα is encoded by the gene ESR1.
    • Fan S, Ma YX, Wang C, Yuan RQ, Meng Q, Wang JA, Erdos M, Goldberg ID, Webb P, Kushner PJ, Pestell RG, Rosen EM (January 2002). “p300 Modulates the BRCA1 inhibition of estrogen receptor activity”. Cancer Res. 62 (1): 141–51. PMID 11782371.
    • Fajas L, Egler V, Reiter R, Hansen J, Kristiansen K, Debril MB, Miard S, Auwerx J (December 2002). “The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation”. Dev. Cell. 3 (6): 903–10. doi:10.1016/s1534-5807(02)00360-x. PMID 12479814.
    • Kang YK, Guermah M, Yuan CX, Roeder RG (March 2002). “The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro”. Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2642–7. Bibcode:2002PNAS…99.2642K. doi:10.1073/pnas.261715899. PMC 122401. PMID 11867769.
• FEN1,
  • Flap endonuclease 1 is an enzyme that in humans is encoded by the FEN1 gene.
    • Hasan S, Stucki M, Hassa PO, Imhof R, Gehrig P, Hunziker P, Hübscher U, Hottiger MO (June 2001). “Regulation of human flap endonuclease-1 activity by acetylation through the transcriptional coactivator p300”. Mol. Cell. 7 (6): 1221–31. doi:10.1016/s1097-2765(01)00272-6. PMID 11430825.
• GPS2,
  • G protein pathway suppressor 2 is a protein that in humans is encoded by the GPS2 gene.
    • Peng YC, Breiding DE, Sverdrup F, Richard J, Androphy EJ (July 2000). “AMF-1/Gps2 binds p300 and enhances its interaction with papillomavirus E2 proteins”. J. Virol. 74 (13): 5872–9. doi:10.1128/jvi.74.13.5872-5879.2000. PMC 112082. PMID 10846067.
• HIF1A,
  • Hypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) that is encoded by the HIF1A gene. The Nobel Prize in Physiology or Medicine 2019 was awarded for the discovery of HIF.
    • Lando D, Peet DJ, Whelan DA, Gorman JJ, Whitelaw ML (February 2002). “Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch”. Science. 295 (5556): 858–61. Bibcode:2002Sci…295..858L. doi:10.1126/science.1068592. PMID 11823643. S2CID 24045310.
    • Freedman SJ, Sun ZY, Poy F, Kung AL, Livingston DM, Wagner G, Eck MJ (April 2002). “Structural basis for recruitment of CBP/p300 by hypoxia-inducible factor-1 alpha”. Proc. Natl. Acad. Sci. U.S.A. 99 (8): 5367–72. Bibcode:2002PNAS…99.5367F. doi:10.1073/pnas.082117899. PMC 122775. PMID 11959990.
• HNF1A,
  • HNF1 homeobox A, also known as HNF1A, is a human gene on chromosome 12. It is ubiquitously expressed in many tissues and cell types. The protein encoded by this gene is a transcription factor that is highly expressed in the liver
    • Ban N, Yamada Y, Someya Y, Miyawaki K, Ihara Y, Hosokawa M, Toyokuni S, Tsuda K, Seino Y (May 2002). “Hepatocyte nuclear factor-1alpha recruits the transcriptional co-activator p300 on the GLUT2 gene promoter”. Diabetes. 51 (5): 1409–18. doi:10.2337/diabetes.51.5.1409. PMID 11978637.
• HNRPU,
  • Heterogeneous nuclear ribonucleoprotein U is a protein that in humans is encoded by the HNRNPU gene.
    • Martens JH, Verlaan M, Kalkhoven E, Dorsman JC, Zantema A (April 2002). “Scaffold/matrix attachment region elements interact with a p300-scaffold attachment factor A complex and are bound by acetylated nucleosomes”. Mol. Cell. Biol. 22 (8): 2598–606. doi:10.1128/mcb.22.8.2598-2606.2002. PMC 133732. PMID 11909954.
• ING4,
  • Inhibitor of growth protein 4 is a protein that in humans is encoded by the ING4 gene.
    • Shiseki M, Nagashima M, Pedeux RM, Kitahama-Shiseki M, Miura K, Okamura S, Onogi H, Higashimoto Y, Appella E, Yokota J, Harris CC (May 2003). “p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity”. Cancer Res. 63 (10): 2373–8. PMID 12750254.
• ING5,
  • Inhibitor of growth protein 5 is a protein that in humans is encoded by the ING5 gene.
    • Shiseki M, Nagashima M, Pedeux RM, Kitahama-Shiseki M, Miura K, Okamura S, Onogi H, Higashimoto Y, Appella E, Yokota J, Harris CC (May 2003). “p29ING4 and p28ING5 bind to p53 and p300, and enhance p53 activity”. Cancer Res. 63 (10): 2373–8. PMID 12750254.
• IRF2,
  • Interferon regulatory factor 2 is a protein that in humans is encoded by the IRF2 gene.
    • Masumi A, Ozato K (June 2001). “Coactivator p300 acetylates the interferon regulatory factor-2 in U937 cells following phorbol ester treatment”. J. Biol. Chem. 276 (24): 20973–80. doi:10.1074/jbc.M101707200. PMID 11304541.
• LEF1,
  • Lymphoid enhancer-binding factor 1 (LEF1) is a protein that in humans is encoded by the LEF1 gene. It’s a member of T cell factor/lymphoid enhancer factor (TCF/LEF) family.
    • Hecht A, Stemmler MP (February 2003). “Identification of a promoter-specific transcriptional activation domain at the C terminus of the Wnt effector protein T-cell factor 4”. J. Biol. Chem. 278 (6): 3776–85. doi:10.1074/jbc.M210081200. PMID 12446687.
• MAF,
  • Transcription factor Maf also known as proto-oncogene c-Maf or V-maf musculoaponeurotic fibrosarcoma oncogene homolog is a transcription factor that in humans is encoded by the MAF gene.
    • Chen Q, Dowhan DH, Liang D, Moore DD, Overbeek PA (July 2002). “CREB-binding protein/p300 co-activation of crystallin gene expression”. J. Biol. Chem. 277 (27): 24081–9. doi:10.1074/jbc.M201821200. PMID 11943779.
• MAML1,
  • Mastermind-like protein 1 is a protein that in humans is encoded by the MAML1 gene.
    • Wallberg AE, Pedersen K, Lendahl U, Roeder RG (November 2002). “p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro”. Mol. Cell. Biol. 22 (22): 7812–9. doi:10.1128/mcb.22.22.7812-7819.2002. PMC 134732. PMID 12391150.
    • Fryer CJ, Lamar E, Turbachova I, Kintner C, Jones KA (June 2002). “Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex”. Genes Dev. 16 (11): 1397–411. doi:10.1101/gad.991602. PMC 186317. PMID 12050117.
• MEF2C,
  • Myocyte-specific enhancer factor 2C also known as MADS box transcription enhancer factor 2, polypeptide C is a protein that in humans is encoded by the MEF2C gene. MEF2C is a transcription factor in the Mef2 family.
    • Sartorelli V, Huang J, Hamamori Y, Kedes L (February 1997). “Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C”. Mol. Cell. Biol. 17 (2): 1010–26. doi:10.1128/mcb.17.2.1010. PMC 231826. PMID 9001254.
• MEF2D,
  • Myocyte-specific enhancer factor 2D is a protein that in humans is encoded by the MEF2D gene.
    • Youn HD, Grozinger CM, Liu JO (July 2000). “Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4”. J. Biol. Chem. 275 (29): 22563–7. doi:10.1074/jbc.C000304200. PMID 10825153.
    • Youn HD, Liu JO (July 2000). “Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2”. Immunity. 13 (1): 85–94. doi:10.1016/s1074-7613(00)00010-8. PMID 10933397.
• MYBL2,
  • Myb-related protein B is a protein that in humans is encoded by the MYBL2 gene.
    • Johnson LR, Johnson TK, Desler M, Luster TA, Nowling T, Lewis RE, Rizzino A (February 2002). “Effects of B-Myb on gene transcription: phosphorylation-dependent activity and acetylation by p300”. J. Biol. Chem. 277 (6): 4088–97. doi:10.1074/jbc.M105112200. PMID11733503
• Mdm2,
  • Mouse double minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene. Mdm2 is an important negative regulator of the p53 tumor suppressor. 
    • Grossman SR, Perez M, Kung AL, Joseph M, Mansur C, Xiao ZX, Kumar S, Howley PM, Livingston DM (October 1998). “p300/MDM2 complexes participate in MDM2-mediated p53 degradation”. Mol. Cell. 2 (4): 405–15. doi:10.1016/s1097-2765(00)80140-9. PMID 9809062.
• MyoD,
  • MyoD, also known as myoblast determination protein 1, is a protein in animals that plays a major role in regulating muscle differentiation. MyoD, which was discovered in the laboratory of Harold M. Weintraub, belongs to a family of proteins known as myogenic regulatory factors
    • Sartorelli V, Huang J, Hamamori Y, Kedes L (February 1997). “Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C”. Mol. Cell. Biol. 17 (2): 1010–26. doi:10.1128/mcb.17.2.1010. PMC 231826. PMID 9001254.
    • Lau P, Bailey P, Dowhan DH, Muscat GE (January 1999). “Exogenous expression of a dominant negative RORalpha1 vector in muscle cells impairs differentiation: RORalpha1 directly interacts with p300 and myoD”. Nucleic Acids Res. 27 (2): 411–20. doi:10.1093/nar/27.2.411. PMC 148194. PMID 9862959.
• MEF2A,
  • Myocyte-specific enhancer factor 2A is a protein that in humans is encoded by the MEF2A gene. MEF2A is a transcription factor in the Mef2 family. In humans it is located on chromosome 15q26. Certain mutations in MEF2A cause an autosomal dominant form of coronary artery disease and myocardial infarction.
    • De Luca A, Severino A, De Paolis P, Cottone G, De Luca L, De Falco M, Porcellini A, Volpe M, Condorelli G (February 2003). “p300/cAMP-response-element-binding-protein (‘CREB’)-binding protein (CBP) modulates co-operation between myocyte enhancer factor 2A (MEF2A) and thyroid hormone receptor-retinoid X receptor”. Biochem. J. 369 (Pt 3): 477–84. doi:10.1042/BJ20020057. PMC 1223100. PMID 12371907.
• NCOA6,
  • Nuclear receptor coactivator 6 is a protein that in humans is encoded by the NCOA6 gene.
    • Ko L, Cardona GR, Chin WW (May 2000). “Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions as a general coactivator”. Proc. Natl. Acad. Sci. U.S.A. 97 (11): 6212–7. Bibcode:2000PNAS…97.6212K. doi:10.1073/pnas.97.11.6212. PMC 18584. PMID 10823961.
• NFATC2,
  • Nuclear factor of activated T-cells, cytoplasmic 2 is a protein that in humans is encoded by the NFATC2 gene.
    • García-Rodríguez C, Rao A (June 1998). “Nuclear factor of activated T cells (NFAT)-dependent transactivation regulated by the coactivators p300/CREB-binding protein (CBP)”. J. Exp. Med. 187 (12): 2031–6. doi:10.1084/jem.187.12.2031. PMC 2212364. PMID 9625762.
• NPAS2,
  • Neuronal PAS domain protein 2 (NPAS2) also known as member of PAS protein 4 (MOP4) is a transcription factor protein that in humans is encoded by the NPAS2 gene. NPAS2 is paralogous to CLOCK, and both are key proteins involved in the maintenance of circadian rhythms in mammals.
    • Curtis AM, Seo SB, Westgate EJ, Rudic RD, Smyth EM, Chakravarti D, FitzGerald GA, McNamara P (February 2004). “Histone acetyltransferase-dependent chromatin remodeling and the vascular clock”. J. Biol. Chem. 279 (8): 7091–7. doi:10.1074/jbc.M311973200. PMID 14645221.
• P53,
  • p53, also known as Tumor protein P53, cellular tumor antigen p53, or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins are crucial in vertebrates, where they prevent cancer formation.
    • Grossman SR, Perez M, Kung AL, Joseph M, Mansur C, Xiao ZX, Kumar S, Howley PM, Livingston DM (October 1998). “p300/MDM2 complexes participate in MDM2-mediated p53 degradation”. Mol. Cell. 2 (4): 405–15. doi:10.1016/s1097-2765(00)80140-9. PMID 9809062.
    • Avantaggiati ML, Ogryzko V, Gardner K, Giordano A, Levine AS, Kelly K (1997). “Recruitment of p300/CBP in p53-dependent signal pathways”. Cell. 89 (7): 1175–84. doi:10.1016/s0092-8674(00)80304-9. PMID 9215639. S2CID 14375605.
    • An W, Kim J, Roeder RG (June 2004). “Ordered cooperative functions of PRMT1, p300, and CARM1 in transcriptional activation by p53”. Cell. 117 (6): 735–48. doi:10.1016/j.cell.2004.05.009. PMID 15186775.
    • Pastorcic M, Das HK (November 2000). “Regulation of transcription of the human presenilin-1 gene by ets transcription factors and the p53 protooncogene”. J. Biol. Chem. 275 (45): 34938–45. doi:10.1074/jbc.M005411200. PMID 10942770.
    • Livengood JA, Scoggin KE, Van Orden K, McBryant SJ, Edayathumangalam RS, Laybourn PJ, Nyborg JK (March 2002). “p53 Transcriptional activity is mediated through the SRC1-interacting domain of CBP/p300”. J. Biol. Chem. 277 (11): 9054–61. doi:10.1074/jbc.M108870200. PMID 11782467.
• PAX6,
  • Paired box protein Pax-6, also known as aniridia type II protein (AN2) or oculorhombin, is a protein that in humans is encoded by the PAX6 gene.
    • Hussain MA, Habener JF (October 1999). “Glucagon gene transcription activation mediated by synergistic interactions of pax-6 and cdx-2 with the p300 co-activator”. J. Biol. Chem. 274 (41): 28950–7. doi:10.1074/jbc.274.41.28950. PMID 10506141.
• PCNA,
  • Proliferating cell nuclear antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication.
    • Hasan S, Hassa PO, Imhof R, Hottiger MO (March 2001). “Transcription coactivator p300 binds PCNA and may have a role in DNA repair synthesis”. Nature. 410 (6826): 387–91. Bibcode:2001Natur.410..387H. doi:10.1038/35066610. PMID 11268218. S2CID 2129847.
• PROX1,
  • Prospero homeobox protein 1 is a protein that in humans is encoded by the PROX1 gene. The Prox1 gene is critical for the development of multiple tissues. Prox1 activity is necessary and sufficient to specify a lymphatic endothelial cell fate in endothelial progenitors located in the embryonic veins.
    • Chen Q, Dowhan DH, Liang D, Moore DD, Overbeek PA (July 2002). “CREB-binding protein/p300 co-activation of crystallin gene expression”. J. Biol. Chem. 277 (27): 24081–9. doi:10.1074/jbc.M201821200. PMID 11943779.
• PTMA,
  • Thymosin α₁ is a peptide fragment derived from prothymosin alpha, a protein that in humans is encoded by the PTMA gene.
    • Subramanian C, Hasan S, Rowe M, Hottiger M, Orre R, Robertson ES (May 2002). “Epstein-Barr virus nuclear antigen 3C and prothymosin alpha interact with the p300 transcriptional coactivator at the CH1 and CH3/HAT domains and cooperate in regulation of transcription and histone acetylation”. J. Virol. 76 (10): 4699–708. doi:10.1128/jvi.76.10.4699-4708.2002. PMC 136123. PMID 11967287.
• PPARA,
  • Peroxisome proliferator-activated receptor alpha (PPAR-α), also known as NR1C1, is a nuclear receptor protein functioning as a transcription factor that in humans is encoded by the PPARA gene. 
    • Dowell P, Ishmael JE, Avram D, Peterson VJ, Nevrivy DJ, Leid M (December 1997). “p300 functions as a coactivator for the peroxisome proliferator-activated receptor alpha”. J. Biol. Chem. 272 (52): 33435–43. doi:10.1074/jbc.272.52.33435. PMID 9407140.
    • Dowell P, Ishmael JE, Avram D, Peterson VJ, Nevrivy DJ, Leid M (May 1999). “Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein”. J. Biol. Chem. 274 (22): 15901–7. doi:10.1074/jbc.274.22.15901. PMID 10336495.
• PPARG,
  • Peroxisome proliferator- activated receptor gamma, also known as the glitazone reverse insulin resistance receptor, or NR1C3 is a type II nuclear receptor functioning as a transcription factor that in humans is encoded by the PPARG gene.
    • Fajas L, Egler V, Reiter R, Hansen J, Kristiansen K, Debril MB, Miard S, Auwerx J (December 2002). “The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation”. Dev. Cell. 3 (6): 903–10. doi:10.1016/s1534-5807(02)00360-x. PMID 12479814.
    • Kodera Y, Takeyama K, Murayama A, Suzawa M, Masuhiro Y, Kato S (October 2000). “Ligand type-specific interactions of peroxisome proliferator-activated receptor gamma with transcriptional coactivators”. J. Biol. Chem. 275 (43): 33201–4. doi:10.1074/jbc.C000517200. PMID 10944516.
• RORA,
  • RAR-related orphan receptor alpha (RORα), also known as NR1F1 is a nuclear receptor that in humans is encoded by the RORA gene. RORα participates in the transcriptional regulation of some genes involved in circadian rhythm. In mice, RORα is essential for development of cerebellum through direct regulation of genes expressed in Purkinje cells. It also plays an essential role in the development of type 2 innate lymphoid cells (ILC2) and mutant animals are ILC2 deficient. In addition, although present in normal numbers, the ILC3 and Th17 cells from RORα deficient mice are defective for cytokine production.
    • Lau P, Bailey P, Dowhan DH, Muscat GE (January 1999). “Exogenous expression of a dominant negative RORalpha1 vector in muscle cells impairs differentiation: RORalpha1 directly interacts with p300 and myoD”. Nucleic Acids Res. 27 (2): 411–20. doi:10.1093/nar/27.2.411. PMC 148194. PMID 9862959.
• RELA,
  • Transcription factor p65 also known as nuclear factor NF-kappa-B p65 subunit is a protein that in humans is encoded by the RELA gene.
    • Kiernan R, Brès V, Ng RW, Coudart MP, El Messaoudi S, Sardet C, Jin DY, Emiliani S, Benkirane M (January 2003). “Post-activation turn-off of NF-kappa B-dependent transcription is regulated by acetylation of p65”. J. Biol. Chem. 278 (4): 2758–66. doi:10.1074/jbc.M209572200. PMID 12419806.
    • Gerritsen ME, Williams AJ, Neish AS, Moore S, Shi Y, Collins T (April 1997). “CREB-binding protein/p300 are transcriptional coactivators of p65”. Proc. Natl. Acad. Sci. U.S.A. 94 (7): 2927–32. Bibcode:1997PNAS…94.2927G. doi:10.1073/pnas.94.7.2927. PMC 20299. PMID 9096323.
• SMAD1,
  • Mothers against decapentaplegic homolog 1 also known as SMAD family member 1 or SMAD1 is a protein that in humans is encoded by the SMAD1 gene.
    • Pearson KL, Hunter T, Janknecht R (December 1999). “Activation of Smad1-mediated transcription by p300/CBP”. Biochim. Biophys. Acta. 1489 (2–3): 354–64. doi:10.1016/S0167-4781(99)00166-9. PMID 10673036.
    • Nakashima K, Yanagisawa M, Arakawa H, Kimura N, Hisatsune T, Kawabata M, Miyazono K, Taga T (April 1999). “Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300”. Science. 284 (5413): 479–82. Bibcode:1999Sci…284..479N. doi:10.1126/science.284.5413.479. PMID 10205054.
• SMAD2,
  • Mothers against decapentaplegic homolog 2 also known as SMAD family member 2 or SMAD2 is a protein that in humans is encoded by the SMAD2 gene. MAD homolog 2 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene ‘mothers against decapentaplegic’ (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways.
    • Wotton D, Lo RS, Lee S, Massagué J (April 1999). “A Smad transcriptional corepressor”. Cell. 97 (1): 29–39. doi:10.1016/S0092-8674(00)80712-6. PMID 10199400.
    • Pessah M, Prunier C, Marais J, Ferrand N, Mazars A, Lallemand F, Gauthier JM, Atfi A (May 2001). “c-Jun interacts with the corepressor TG-interacting factor (TGIF) to suppress Smad2 transcriptional activity”. Proc. Natl. Acad. Sci. U.S.A. 98 (11): 6198–203. Bibcode:2001PNAS…98.6198P. doi:10.1073/pnas.101579798. PMC 33445. PMID 11371641.
• SMAD7,
  • Mothers against decapentaplegic homolog 7 or SMAD7 is a protein that in humans is encoded by the SMAD7 gene.
    • Grönroos E, Hellman U, Heldin CH, Ericsson J (September 2002). “Control of Smad7 stability by competition between acetylation and ubiquitination”. Mol. Cell. 10 (3): 483–93. doi:10.1016/s1097-2765(02)00639-1. PMID 12408818.
• SNIP1,
  • Smad nuclear-interacting protein 1 is a protein that in humans is encoded by the SNIP1 gene.
    • Kim RH, Wang D, Tsang M, Martin J, Huff C, de Caestecker MP, Parks WT, Meng X, Lechleider RJ, Wang T, Roberts AB (July 2000). “A novel smad nuclear interacting protein, SNIP1, suppresses p300-dependent TGF-beta signal transduction”. Genes Dev. 14 (13): 1605–16. doi:10.1101/gad.14.13.1605. PMC 316742. PMID 10887155.
• SS18,
  • Protein SSXT is a protein that in humans is encoded by the SS18 gene.
    • Eid JE, Kung AL, Scully R, Livingston DM (September 2000). “p300 interacts with the nuclear proto-oncoprotein SYT as part of the active control of cell adhesion”. Cell. 102 (6): 839–48. doi:10.1016/s0092-8674(00)00072-6. PMID 11030627.
• STAT3,
  • Signal transducer and activator of transcription 3 (STAT3) is a transcription factor which in humans is encoded by the STAT3 gene. It is a member of the STAT protein family.
    • Nakashima K, Yanagisawa M, Arakawa H, Kimura N, Hisatsune T, Kawabata M, Miyazono K, Taga T (April 1999). “Synergistic signaling in fetal brain by STAT3-Smad1 complex bridged by p300”. Science. 284 (5413): 479–82. Bibcode:1999Sci…284..479N. doi:10.1126/science.284.5413.479. PMID 10205054.
• STAT6,
  • Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that belongs to the Signal Transducer and Activator of Transcription (STAT) family of proteins. The proteins of STAT family transmit signals from a receptor complex to the nucleus and activate gene expression.
    • McDonald C, Reich NC (July 1999). “Cooperation of the transcriptional coactivators CBP and p300 with Stat6”. J. Interferon Cytokine Res. 19 (7): 711–22. doi:10.1089/107999099313550. PMID 10454341.
• TAL1,
  • Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that belongs to the Signal Transducer and Activator of Transcription (STAT) family of proteins. The proteins of STAT family transmit signals from a receptor complex to the nucleus and activate gene expression.
    • Huang S, Qiu Y, Stein RW, Brandt SJ (September 1999). “p300 functions as a transcriptional coactivator for the TAL1/SCL oncoprotein”. Oncogene. 18 (35): 4958–67. doi:10.1038/sj.onc.1202889. PMID 10490830.
• TCF3,
  • Transcription factor 3, also known as TCF3, is a protein that in humans is encoded by the TCF3 gene. TCF3 has been shown to directly enhance Hes1 expression.
    • Bradney C, Hjelmeland M, Komatsu Y, Yoshida M, Yao TP, Zhuang Y (January 2003). “Regulation of E2A activities by histone acetyltransferases in B lymphocyte development”. J. Biol. Chem. 278 (4): 2370–6. doi:10.1074/jbc.M211464200. PMID 12435739.
• TFAP2A,
  • Transcription factor AP-2 alpha, also known as TFAP2A, is a protein that in humans is encoded by the TFAP2A gene.
    • Bragança J, Eloranta JJ, Bamforth SD, Ibbitt JC, Hurst HC, Bhattacharya S (May 2003). “Physical and functional interactions among AP-2 transcription factors, p300/CREB-binding protein, and CITED2”. J. Biol. Chem. 278 (18): 16021–9. doi:10.1074/jbc.M208144200. PMID 12586840.
• TGS1,
  • Trimethylguanosine synthase is an enzyme that in humans is encoded by the TGS1 gene.
    • Misra P, Qi C, Yu S, Shah SH, Cao WQ, Rao MS, Thimmapaya B, Zhu Y, Reddy JK (May 2002). “Interaction of PIMT with transcriptional coactivators CBP, p300, and PBP differential role in transcriptional regulation”. J. Biol. Chem. 277 (22): 20011–9. doi:10.1074/jbc.M201739200. PMID 11912212.
• TRERF1,
  • Transcriptional-regulating factor 1 is a protein that in humans is encoded by the TRERF1 gene.
    • Gizard F, Lavallée B, DeWitte F, Hum DW (September 2001). “A novel zinc finger protein TReP-132 interacts with CBP/p300 to regulate human CYP11A1 gene expression”. J. Biol. Chem. 276 (36): 33881–92. doi:10.1074/jbc.M100113200. PMID 11349124
• TSG101,
  • Tumor susceptibility gene 101, also known as TSG101, is a human gene that encodes for a cellular protein of the same name.
    • Sun Z, Pan J, Hope WX, Cohen SN, Balk SP (August 1999). “Tumor susceptibility gene 101 protein represses androgen receptor transactivation and interacts with p300”. Cancer. 86 (4): 689–96. doi:10.1002/(sici)1097-0142(19990815)86:4<689::aid-cncr19>3.0.co;2-p. PMID 10440698. S2CID 26971556.
• THRA,
  • Thyroid hormone receptor alpha (TR-alpha) also known as nuclear receptor subfamily 1, group A, member 1 (NR1A1), is a nuclear receptor protein that in humans is encoded by the THRA gene.
    • De Luca A, Severino A, De Paolis P, Cottone G, De Luca L, De Falco M, Porcellini A, Volpe M, Condorelli G (February 2003). “p300/cAMP-response-element-binding-protein (‘CREB’)-binding protein (CBP) modulates co-operation between myocyte enhancer factor 2A (MEF2A) and thyroid hormone receptor-retinoid X receptor”. Biochem. J. 369 (Pt 3): 477–84. doi:10.1042/BJ20020057. PMC 1223100. PMID 12371907.
• TWIST1,
  • Twist-related protein 1 (TWIST1) also known as class A basic helix–loop–helix protein 38 (bHLHa38) is a basic helix-loop-helix transcription factor that in humans is encoded by the TWIST1 gene.
    • Hamamori Y, Sartorelli V, Ogryzko V, Puri PL, Wu HY, Wang JY, Nakatani Y, Kedes L (February 1999). “Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein E1A”. Cell. 96 (3): 405–13. doi:10.1016/S0092-8674(00)80553-X. PMID 10025406.
• YY1,
  • YY1 is a transcriptional repressor protein in humans that is encoded by the YY1 gene.
    • Yao YL, Yang WM, Seto E (September 2001). “Regulation of transcription factor YY1 by acetylation and deacetylation”. Mol. Cell. Biol. 21 (17): 5979–91. doi:10.1128/mcb.21.17.5979-5991.2001. PMC 87316. PMID 11486036.
    • Lee JS, Galvin KM, See RH, Eckner R, Livingston D, Moran E, Shi Y (May 1995). “Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300”. Genes Dev. 9 (10): 1188–98. doi:10.1101/gad.9.10.1188. PMID 7758944.
• Zif268.
  • EGR-1 also known as ZNF268 or NGFI-A is a protein that in humans is encoded by the EGR1 gene.
    • Silverman ES, Du J, Williams AJ, Wadgaonkar R, Drazen JM, Collins T (November 1998). “cAMP-response-element-binding-protein-binding protein (CBP) and p300 are transcriptional co-activators of early growth response factor-1 (Egr-1)”. Biochem. J. 336 (1): 183–9. doi:10.1042/bj3360183. PMC 1219856. PMID 9806899.