Actr
Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300.
Karamouzis MV, Konstantinopoulos PA, Papavassiliou AG (April 2007). “Roles of CREB-binding protein (CBP)/p300 in respiratory epithelium tumorigenesis”. Cell Research. 17 (4): 324–332. doi:10.1038/cr.2007.10. PMID 17372613. S2CID 36084602.
Dyson HJ, Wright PE (March 2016). “Role of Intrinsic Protein Disorder in the Function and Interactions of the Transcriptional Coactivators CREB-binding Protein (CBP) and p300”. The Journal of Biological Chemistry. 291 (13): 6714–6722. doi:10.1074/jbc.R115.692020. PMC 4807259. PMID 26851278.
Ap-1
Activator protein 1 (AP-1) is a transcription factor that regulates gene expression in response to a variety of stimuli, including cytokines, growth factors, stress, and bacterial and viral infections. AP-1 controls a number of cellular processes including differentiation, proliferation, and apoptosis.
Valor LM, Viosca J, Lopez-Atalaya JP, Barco A (2013-07-31). “Lysine acetyltransferases CBP and p300 as therapeutic targets in cognitive and neurodegenerative disorders”. Current Pharmaceutical Design. 19 (28): 5051–5064. doi:10.2174/13816128113199990382. PMC 3722569. PMID 23448461.
Apc5
Anaphase-promoting complex is an E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the 26S proteasome. The APC/C is a large complex of 11–13 subunit proteins, including a cullin (Apc2) and RING (Apc11) subunit much like SCF.
Rouaux C, Loeffler JP, Boutillier AL (September 2004). “Targeting CREB-binding protein (CBP) loss of function as a therapeutic strategy in neurological disorders”. Biochemical Pharmacology. 68 (6): 1157–1164. doi:10.1016/j.bcp.2004.05.035. PMID 15313413.
Apc7
Anaphase-promoting complex is an E3 ubiquitin ligase that marks target cell cycle proteins for degradation by the 26S proteasome. The APC/C is a large complex of 11–13 subunit proteins, including a cullin (Apc2) and RING (Apc11) subunit much like SCF.
Rouaux C, Loeffler JP, Boutillier AL (September 2004). “Targeting CREB-binding protein (CBP) loss of function as a therapeutic strategy in neurological disorders”. Biochemical Pharmacology. 68 (6): 1157–1164. doi:10.1016/j.bcp.2004.05.035. PMID 15313413.
Atr
Serine/threonine-protein kinase ATR also known as ataxia telangiectasia and Rad3-related protein (ATR) or FRAP-related protein 1 (FRP1) is an enzyme that, in humans, is encoded by the ATR gene
Dutto I, Scalera C, Prosperi E (April 2018). “CREBBP and p300 lysine acetyl transferases in the DNA damage response”. Cellular and Molecular Life Sciences. 75 (8): 1325–1338. doi:10.1007/s00018-017-2717-4. PMID 29170789. S2CID 3951961.
BRCA1
Breast cancer type 1 susceptibility protein is a protein that in humans is encoded by the BRCA1 gene.
Dutto I, Scalera C, Prosperi E (April 2018). “CREBBP and p300 lysine acetyl transferases in the DNA damage response”. Cellular and Molecular Life Sciences. 75 (8): 1325–1338. doi:10.1007/s00018-017-2717-4. PMID 29170789. S2CID 3951961.
Mullan PB, Quinn JE, Harkin DP (September 2006). “The role of BRCA1 in transcriptional regulation and cell cycle control”. Oncogene. 25 (43): 5854–5863. doi:10.1038/sj.onc.1209872. PMID 16998500. S2CID 41157893
C-FOS
Protein c-Fos is a proto-oncogene that is the human homolog of the retroviral oncogene v-fos. It is encoded in humans by the FOS gene. It was first discovered in rat fibroblasts as the transforming gene of the FBJ MSV.
Karamouzis MV, Konstantinopoulos PA, Papavassiliou AG (April 2007). “Roles of CREB-binding protein (CBP)/p300 in respiratory epithelium tumorigenesis”. Cell Research. 17 (4): 324–332. doi:10.1038/cr.2007.10. PMID 17372613. S2CID 36084602.
C-JUN
Transcription factor Jun is a protein that in humans is encoded by the JUN gene. c-Jun, in combination with protein c-Fos, forms the AP-1 early response transcription factor. It was first identified as the Fos-binding protein p39
Blobel GA (2000-02-01). “CREB-binding protein and p300: molecular integrators of hematopoietic transcription”. Blood. 95 (3): 745–755. doi:10.1182/blood.V95.3.745.003k05_745_755. ISSN 1528-0020. PMID 10648382.
C-MYB
Myb genes are part of a large gene family of transcription factors found in animals and plants. In humans, it includes Myb proto-oncogene like 1 and Myb-related protein B in addition to MYB proper.
Dutta R, Tiu B, Sakamoto KM (September 2016). “CBP/p300 acetyltransferase activity in hematologic malignancies”. Molecular Genetics and Metabolism. 119 (1–2): 37–43. doi:10.1016/j.ymgme.2016.06.013. PMID 27380996.
Dyson HJ, Wright PE (March 2016). “Role of Intrinsic Protein Disorder in the Function and Interactions of the Transcriptional Coactivators CREB-binding Protein (CBP) and p300”. The Journal of Biological Chemistry. 291 (13): 6714–6722. doi:10.1074/jbc.R115.692020. PMC 4807259. PMID 26851278.
Chrebp
Carbohydrate-responsive element-binding protein (ChREBP) also known as MLX-interacting protein-like (MLXIPL) is a protein that in humans is encoded by the MLXIPL gene. The protein name derives from the protein’s interaction with carbohydrate response element sequences of DNA.
Yao W, Wang T, Huang F (2018). “p300/CBP as a Key Nutritional Sensor for Hepatic Energy Homeostasis and Liver Fibrosis”. BioMed Research International. 2018: 8168791. doi:10.1155/2018/8168791. PMC 5976926. PMID 29862292.
CITED2
Cbp/p300-interacting transactivator 2 is a protein that in humans is encoded by the CITED2 gene.
Dyson HJ, Wright PE (March 2016). “Role of Intrinsic Protein Disorder in the Function and Interactions of the Transcriptional Coactivators CREB-binding Protein (CBP) and p300”. The Journal of Biological Chemistry. 291 (13): 6714–6722. doi:10.1074/jbc.R115.692020. PMC 4807259. PMID 26851278.
Ddb1 (p127)
DNA damage-binding protein 1 is a protein that in humans is encoded by the DDB1 gene.
Dutto I, Scalera C, Prosperi E (April 2018). “CREBBP and p300 lysine acetyl transferases in the DNA damage response”. Cellular and Molecular Life Sciences. 75 (8): 1325–1338. doi:10.1007/s00018-017-2717-4. PMID 29170789. S2CID 3951961.
Ddb2 (p48)
DNA damage-binding protein 2 is a protein that in humans is encoded by the DDB2 gene.
Dutto I, Scalera C, Prosperi E (April 2018). “CREBBP and p300 lysine acetyl transferases in the DNA damage response”. Cellular and Molecular Life Sciences. 75 (8): 1325–1338. doi:10.1007/s00018-017-2717-4. PMID 29170789. S2CID 3951961.
Ddx3
Helicases are a class of enzymes thought to be vital to all organisms. Their main function is to unpack an organism’s genetic material. Helicases are motor proteins
Yao W, Wang T, Huang F (2018). “p300/CBP as a Key Nutritional Sensor for Hepatic Energy Homeostasis and Liver Fibrosis”. BioMed Research International. 2018: 8168791. doi:10.1155/2018/8168791. PMC 5976926. PMID 29862292.
Dhx9
ATP-dependenNewton AL, Sharpe BK, Kwan A, Mackay JP, Crossley M (May 2000). “The transactivation domain within cysteine/histidine-rich region 1 of CBP comprises two novel zinc-binding modules”. The Journal of Biological Chemistry. 275 (20): 15128–15134. doi:10.1074/jbc.M910396199. PMID 10748221.t RNA helicase A is an enzyme that in humans is encoded by the DHX9 gene.
DNA2 helicase
The DNA2 helicase can unwind DNA duplexes to generate ssDNA regions (7,30), but unlike other known helicases, it requires the presence of a single-stranded 5′ end adjacent to the double-stranded DNA (dsDNA) to be unwound (33).
Dutto I, Scalera C, Prosperi E (April 2018). “CREBBP and p300 lysine acetyl transferases in the DNA damage response”. Cellular and Molecular Life Sciences. 75 (8): 1325–1338. doi:10.1007/s00018-017-2717-4. PMID 29170789. S2CID 3951961.
E1A
Adenovirus E1a proteins function in transcriptional activation, transcriptional repression, cellular DNA synthesis induction, and cellular transformation.
Dyson HJ, Wright PE (March 2016). “Role of Intrinsic Protein Disorder in the Function and Interactions of the Transcriptional Coactivators CREB-binding Protein (CBP) and p300”. The Journal of Biological Chemistry. 291 (13): 6714–6722. doi:10.1074/jbc.R115.692020. PMC 4807259. PMID 26851278.
Blobel GA (2000-02-01). “CREB-binding protein and p300: molecular integrators of hematopoietic transcription”. Blood. 95 (3): 745–755. doi:10.1182/blood.V95.3.745.003k05_745_755. ISSN 1528-0020. PMID 10648382.
E2F
E2F is a group of genes that encodes a family of transcription factors (TF) in higher eukaryotes. Three of them are activators: E2F1, 2 and E2F3a. Six others act as suppressors: E2F3b, E2F4-8. All of them are involved in the cell cycle regulation and synthesis of DNA in mammalian cells.
Karamouzis MV, Konstantinopoulos PA, Papavassiliou AG (April 2007). “Roles of CREB-binding protein (CBP)/p300 in respiratory epithelium tumorigenesis”. Cell Research. 17 (4): 324–332. doi:10.1038/cr.2007.10. PMID 17372613. S2CID 36084602.
Dutta R, Tiu B, Sakamoto KM (September 2016). “CBP/p300 acetyltransferase activity in hematologic malignancies”. Molecular Genetics and Metabolism. 119 (1–2): 37–43. doi:10.1016/j.ymgme.2016.06.013. PMID 27380996.
Elk1
ETS Like-1 protein Elk-1 is a protein that in humans is encoded by the ELK1. Elk-1 functions as a transcription activator. It is classified as a ternary complex factor (TCF)
Karamouzis MV, Konstantinopoulos PA, Papavassiliou AG (April 2007). “Roles of CREB-binding protein (CBP)/p300 in respiratory epithelium tumorigenesis”. Cell Research. 17 (4): 324–332. doi:10.1038/cr.2007.10. PMID 17372613. S2CID 36084602.
ER
Estrogen receptors (ERs) are a group of proteins found inside cells. They are receptors that are activated by the hormone estrogen (17β-estradiol).
Valor LM, Viosca J, Lopez-Atalaya JP, Barco A (2013-07-31). “Lysine acetyltransferases CBP and p300 as therapeutic targets in cognitive and neurodegenerative disorders”. Current Pharmaceutical Design. 19 (28): 5051–5064. doi:10.2174/13816128113199990382. PMC 3722569. PMID 23448461.
Ets1
Protein C-ets-1 is a protein that in humans is encoded by the ETS1 gene. The protein encoded by this gene belongs to the ETS family of transcription factors.
Karamouzis MV, Konstantinopoulos PA, Papavassiliou AG (April 2007). “Roles of CREB-binding protein (CBP)/p300 in respiratory epithelium tumorigenesis”. Cell Research. 17 (4): 324–332. doi:10.1038/cr.2007.10. PMID 17372613. S2CID 36084602.
Fen1
Flap endonuclease 1 is an enzyme that in humans is encoded by the FEN1 gene.
Dutto I, Scalera C, Prosperi E (April 2018). “CREBBP and p300 lysine acetyl transferases in the DNA damage response”. Cellular and Molecular Life Sciences. 75 (8): 1325–1338. doi:10.1007/s00018-017-2717-4. PMID 29170789. S2CID 3951961.
Foxo1
Forkhead box protein O1 (FOXO1), also known as forkhead in rhabdomyosarcoma (FKHR), is a protein that in humans is encoded by the FOXO1 gene. FOXO1 is a transcription factor that plays important roles in regulation of gluconeogenesis and glycogenolysis
Yao W, Wang T, Huang F (2018). “p300/CBP as a Key Nutritional Sensor for Hepatic Energy Homeostasis and Liver Fibrosis”. BioMed Research International. 2018: 8168791. doi:10.1155/2018/8168791. PMC 5976926. PMID 29862292.
Gal4
The Gal4 transcription factor is a positive regulator of gene expression of galactose-induced genes. This protein represents a large fungal family of transcription factors, Gal4 family, which includes over 50 members in the yeast Saccharomyces cerevisiae e.g. Oaf1, Pip2, Pdr1, Pdr3, Leu3.
Valor LM, Viosca J, Lopez-Atalaya JP, Barco A (2013-07-31). “Lysine acetyltransferases CBP and p300 as therapeutic targets in cognitive and neurodegenerative disorders”. Current Pharmaceutical Design. 19 (28): 5051–5064. doi:10.2174/13816128113199990382. PMC 3722569. PMID 23448461.
GATA1
GATA-binding factor 1 or GATA-1 is the founding member of the GATA family of transcription factors. This protein is widely expressed throughout vertebrate species. In humans and mice, it is encoded by the GATA1 and Gata1 genes, respectively. These genes are located on the X chromosome
Karamouzis MV, Konstantinopoulos PA, Papavassiliou AG (April 2007). “Roles of CREB-binding protein (CBP)/p300 in respiratory epithelium tumorigenesis”. Cell Research. 17 (4): 324–332. doi:10.1038/cr.2007.10. PMID 17372613. S2CID 36084602.
Dutta R, Tiu B, Sakamoto KM (September 2016). “CBP/p300 acetyltransferase activity in hematologic malignancies”. Molecular Genetics and Metabolism. 119 (1–2): 37–43. doi:10.1016/j.ymgme.2016.06.013. PMID 27380996.
Cantor AB, Orkin SH (May 2002). “Transcriptional regulation of erythropoiesis: an affair involving multiple partners”. Oncogene. 21 (21): 3368–3376. doi:10.1038/sj.onc.1205326. PMID 12032775. S2CID 33364155
GR
The glucocorticoid receptor also known as NR3C1 is the receptor to which cortisol and other glucocorticoids bind.
Valor LM, Viosca J, Lopez-Atalaya JP, Barco A (2013-07-31). “Lysine acetyltransferases CBP and p300 as therapeutic targets in cognitive and neurodegenerative disorders”. Current Pharmaceutical Design. 19 (28): 5051–5064. doi:10.2174/13816128113199990382. PMC 3722569. PMID 23448461.
hATF4
Activating transcription factor 4 , also known as ATF4, is a protein that in humans is encoded by the ATF4 gene.
Newton AL, Sharpe BK, Kwan A, Mackay JP, Crossley M (May 2000). “The transactivation domain within cysteine/histidine-rich region 1 of CBP comprises two novel zinc-binding modules”. The Journal of Biological Chemistry. 275 (20): 15128–15134. doi:10.1074/jbc.M910396199. PMID 10748221.
HNF-1
HNF1 homeobox A, also known as HNF1A, is a human gene on chromosome 12. It is ubiquitously expressed in many tissues and cell types. The protein encoded by this gene is a transcription factor that is highly expressed in the liver
Newton AL, Sharpe BK, Kwan A, Mackay JP, Crossley M (May 2000). “The transactivation domain within cysteine/histidine-rich region 1 of CBP comprises two novel zinc-binding modules”. The Journal of Biological Chemistry. 275 (20): 15128–15134. doi:10.1074/jbc.M910396199. PMID 10748221.
Hif-1α
Hypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) that is encoded by the HIF1A gene. The Nobel Prize in Physiology or Medicine 2019 was awarded for the discovery of HIF.
Dyson HJ, Wright PE (March 2016). “Role of Intrinsic Protein Disorder in the Function and Interactions of the Transcriptional Coactivators CREB-binding Protein (CBP) and p300”. The Journal of Biological Chemistry. 291 (13): 6714–6722. doi:10.1074/jbc.R115.692020. PMC 4807259. PMID 26851278.
Ku70
Ku70 is a protein that, in humans, is encoded by the XRCC6 gene.
Dutto I, Scalera C, Prosperi E (April 2018). “CREBBP and p300 lysine acetyl transferases in the DNA damage response”. Cellular and Molecular Life Sciences. 75 (8): 1325–1338. doi:10.1007/s00018-017-2717-4. PMID 29170789. S2CID 3951961.
MDM2
Mouse double minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene. Mdm2 is an important negative regulator of the p53 tumor suppressor.
Karamouzis MV, Konstantinopoulos PA, Papavassiliou AG (April 2007). “Roles of CREB-binding protein (CBP)/p300 in respiratory epithelium tumorigenesis”. Cell Research. 17 (4): 324–332. doi:10.1038/cr.2007.10. PMID 17372613. S2CID 36084602.
MLL
Histone-lysine N-methyltransferase 2A also known as acute lymphoblastic leukemia 1 (ALL-1), myeloid/lymphoid or mixed-lineage leukemia 1 (MLL1), or zinc finger protein HRX (HRX) is an enzyme that in humans is encoded by the KMT2A gene.
Dyson HJ, Wright PE (March 2016). “Role of Intrinsic Protein Disorder in the Function and Interactions of the Transcriptional Coactivators CREB-binding Protein (CBP) and p300”. The Journal of Biological Chemistry. 291 (13): 6714–6722. doi:10.1074/jbc.R115.692020. PMC 4807259. PMID 26851278.
MyoD
MyoD, also known as myoblast determination protein 1, is a protein in animals that plays a major role in regulating muscle differentiation. MyoD, which was discovered in the laboratory of Harold M. Weintraub, belongs to a family of proteins known as myogenic regulatory factors
Karamouzis MV, Konstantinopoulos PA, Papavassiliou AG (April 2007). “Roles of CREB-binding protein (CBP)/p300 in respiratory epithelium tumorigenesis”. Cell Research. 17 (4): 324–332. doi:10.1038/cr.2007.10. PMID 17372613. S2CID 36084602.
Dutta R, Tiu B, Sakamoto KM (September 2016). “CBP/p300 acetyltransferase activity in hematologic malignancies”. Molecular Genetics and Metabolism. 119 (1–2): 37–43. doi:10.1016/j.ymgme.2016.06.013. PMID 27380996.
NF-κβ
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli
Dyson HJ, Wright PE (March 2016). “Role of Intrinsic Protein Disorder in the Function and Interactions of the Transcriptional Coactivators CREB-binding Protein (CBP) and p300”. The Journal of Biological Chemistry. 291 (13): 6714–6722. doi:10.1074/jbc.R115.692020. PMC 4807259. PMID 26851278.
Vo N, Goodman RH (April 2001). “CREB-binding protein and p300 in transcriptional regulation”. The Journal of Biological Chemistry. 276 (17): 13505–13508. doi:10.1074/jbc.R000025200. PMID 11279224.
p53
p53, also known as Tumor protein P53, cellular tumor antigen p53, or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins are crucial in vertebrates, where they prevent cancer formation.
Newton AL, Sharpe BK, Kwan A, Mackay JP, Crossley M (May 2000). “The transactivation domain within cysteine/histidine-rich region 1 of CBP comprises two novel zinc-binding modules”. The Journal of Biological Chemistry. 275 (20): 15128–15134. doi:10.1074/jbc.M910396199. PMID 10748221.
Dyson HJ, Wright PE (March 2016). “Role of Intrinsic Protein Disorder in the Function and Interactions of the Transcriptional Coactivators CREB-binding Protein (CBP) and p300”. The Journal of Biological Chemistry. 291 (13): 6714–6722. doi:10.1074/jbc.R115.692020. PMC 4807259. PMID 26851278.
p73
p73 is a protein related to the p53 tumor protein. Because of its structural resemblance to p53, it has also been considered a tumor suppressor. It is involved in cell cycle regulation, and induction of apoptosis.
Karamouzis MV, Konstantinopoulos PA, Papavassiliou AG (April 2007). “Roles of CREB-binding protein (CBP)/p300 in respiratory epithelium tumorigenesis”. Cell Research. 17 (4): 324–332. doi:10.1038/cr.2007.10. PMID 17372613. S2CID 36084602.
Newton AL, Sharpe BK, Kwan A, Mackay JP, Crossley M (May 2000). “The transactivation domain within cysteine/histidine-rich region 1 of CBP comprises two novel zinc-binding modules”. The Journal of Biological Chemistry. 275 (20): 15128–15134. doi:10.1074/jbc.M910396199. PMID 10748221.
Parp1
Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. It is the most abundant of the PARP family of enzymes,
Dutto I, Scalera C, Prosperi E (April 2018). “CREBBP and p300 lysine acetyl transferases in the DNA damage response”. Cellular and Molecular Life Sciences. 75 (8): 1325–1338. doi:10.1007/s00018-017-2717-4. PMID 29170789. S2CID 3951961.
pCREB
CREB-TF is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the genes.
Dyson HJ, Wright PE (March 2016). “Role of Intrinsic Protein Disorder in the Function and Interactions of the Transcriptional Coactivators CREB-binding Protein (CBP) and p300”. The Journal of Biological Chemistry. 291 (13): 6714–6722. doi:10.1074/jbc.R115.692020. PMC 4807259. PMID 26851278.
pCAF
P300/CBP-associated factor (PCAF), also known as K(lysine) acetyltransferase 2B (KAT2B), is a human gene and transcriptional coactivator associated with p53.
Blobel GA (2000-02-01). “CREB-binding protein and p300: molecular integrators of hematopoietic transcription”. Blood. 95 (3): 745–755. doi:10.1182/blood.V95.3.745.003k05_745_755. ISSN 1528-0020. PMID 10648382.
PCNA
Proliferating cell nuclear antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication.
Dutto I, Scalera C, Prosperi E (April 2018). “CREBBP and p300 lysine acetyl transferases in the DNA damage response”. Cellular and Molecular Life Sciences. 75 (8): 1325–1338. doi:10.1007/s00018-017-2717-4. PMID 29170789. S2CID 3951961.
Pit1
POU domain, class 1, transcription factor 1 , also known as POU1F1, is a transcription factor for growth hormone.
Newton AL, Sharpe BK, Kwan A, Mackay JP, Crossley M (May 2000). “The transactivation domain within cysteine/histidine-rich region 1 of CBP comprises two novel zinc-binding modules”. The Journal of Biological Chemistry. 275 (20): 15128–15134. doi:10.1074/jbc.M910396199. PMID 10748221.
RAR
The retinoic acid receptor (RAR) is a type of nuclear receptor which can also act as a ligand-activated transcription factor that is activated by both all-trans retinoic acid and 9-cis retinoic acid the retinoid active derivatives of Vitamin A. They are typically found within the nucleus.
Valor LM, Viosca J, Lopez-Atalaya JP, Barco A (2013-07-31). “Lysine acetyltransferases CBP and p300 as therapeutic targets in cognitive and neurodegenerative disorders”. Current Pharmaceutical Design. 19 (28): 5051–5064. doi:10.2174/13816128113199990382. PMC 3722569. PMID 23448461.
RXR
The retinoid X receptor (RXR) is a type of nuclear receptor that is activated by 9-cis retinoic acid
Valor LM, Viosca J, Lopez-Atalaya JP, Barco A (2013-07-31). “Lysine acetyltransferases CBP and p300 as therapeutic targets in cognitive and neurodegenerative disorders”. Current Pharmaceutical Design. 19 (28): 5051–5064. doi:10.2174/13816128113199990382. PMC 3722569. PMID 23448461.
SCRAP
multiprotein chromatin-remodeling SRCAP complex? SRCAP is one of several proteins that help activate a gene called CREBBP. The protein produced from the CREBBP gene, called CREB binding protein, plays a key role in regulating cell growth and division and is important for normal development.
Newton AL, Sharpe BK, Kwan A, Mackay JP, Crossley M (May 2000). “The transactivation domain within cysteine/histidine-rich region 1 of CBP comprises two novel zinc-binding modules”. The Journal of Biological Chemistry. 275 (20): 15128–15134. doi:10.1074/jbc.M910396199. PMID 10748221.
SMAD
Smads comprise a family of structurally similar proteins that are the main signal transducers for receptors of the transforming growth factor beta (TGF-B) superfamily, which are critically important for regulating cell development and growth.
Karamouzis MV, Konstantinopoulos PA, Papavassiliou AG (April 2007). “Roles of CREB-binding protein (CBP)/p300 in respiratory epithelium tumorigenesis”. Cell Research. 17 (4): 324–332. doi:10.1038/cr.2007.10. PMID 17372613. S2CID 36084602.
Yao W, Wang T, Huang F (2018). “p300/CBP as a Key Nutritional Sensor for Hepatic Energy Homeostasis and Liver Fibrosis”. BioMed Research International. 2018: 8168791. doi:10.1155/2018/8168791. PMC 5976926. PMID 29862292.
Src1
The nuclear receptor coactivator 1 (NCOA1) is a transcriptional coregulatory protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity.
Blobel GA (2000-02-01). “CREB-binding protein and p300: molecular integrators of hematopoietic transcription”. Blood. 95 (3): 745–755. doi:10.1182/blood.V95.3.745.003k05_745_755. ISSN 1528-0020. PMID 10648382.
Srebp1c
Sterol regulatory element-binding transcription factor 1 (SREBF1) also known as sterol regulatory element-binding protein 1 (SREBP-1) is a protein that in humans is encoded by
the SREBF1 gene.
Yao W, Wang T, Huang F (2018). “p300/CBP as a Key Nutritional Sensor for Hepatic Energy Homeostasis and Liver Fibrosis”. BioMed Research International. 2018: 8168791. doi:10.1155/2018/8168791. PMC 5976926. PMID 29862292.
Karamouzis MV, Konstantinopoulos PA, Papavassiliou AG (April 2007). “Roles of CREB-binding protein (CBP)/p300 in respiratory epithelium tumorigenesis”. Cell Research. 17 (4): 324–332. doi:10.1038/cr.2007.10. PMID 17372613. S2CID 36084602.
STAT1
Signal transducer and activator of transcription 1 (STAT1) is a transcription factor which in humans is encoded by the STAT1 gene. It is a member of the STAT protein family.
Dyson HJ, Wright PE (March 2016). “Role of Intrinsic Protein Disorder in the Function and Interactions of the Transcriptional Coactivators CREB-binding Protein (CBP) and p300”. The Journal of Biological Chemistry. 291 (13): 6714–6722. doi:10.1074/jbc.R115.692020. PMC 4807259. PMID 26851278.
STAT2
Signal transducer and activator of transcription 2 is a protein that in humans is encoded by the STAT2 gene. It is a member of the STAT protein family. This protein is critical to the biological response of type I interferons (IFNs).
Dyson HJ, Wright PE (March 2016). “Role of Intrinsic Protein Disorder in the Function and Interactions of the Transcriptional Coactivators CREB-binding Protein (CBP) and p300”. The Journal of Biological Chemistry. 291 (13): 6714–6722. doi:10.1074/jbc.R115.692020. PMC 4807259. PMID 26851278.
Vo N, Goodman RH (April 2001). “CREB-binding protein and p300 in transcriptional regulation”. The Journal of Biological Chemistry. 276 (17): 13505–13508. doi:10.1074/jbc.R000025200. PMID 11279224
STAT3
Signal transducer and activator of transcription 3 (STAT3) is a transcription factor which in humans is encoded by the STAT3 gene. It is a member of the STAT protein family.
Dutta R, Tiu B, Sakamoto KM (September 2016). “CBP/p300 acetyltransferase activity in hematologic malignancies”. Molecular Genetics and Metabolism. 119 (1–2): 37–43. doi:10.1016/j.ymgme.2016.06.013. PMID 27380996.
Sumo
In molecular biology, SUMO proteins are a family of small proteins that are covalently attached to and detached from other proteins in cells to modify their function. This process is called SUMOylation. SUMOylation is a post-translational modification involved in various cellular processes
Dyson HJ, Wright PE (March 2016). “Role of Intrinsic Protein Disorder in the Function and Interactions of the Transcriptional Coactivators CREB-binding Protein (CBP) and p300”. The Journal of Biological Chemistry. 291 (13): 6714–6722. doi:10.1074/jbc.R115.692020. PMC 4807259. PMID 26851278.
Akinsiku OE, Soremekun OS, Soliman ME (February 2021). “Update and Potential Opportunities in CBP [Cyclic Adenosine Monophosphate (cAMP) Response Element-Binding Protein (CREB)-Binding Protein] Research Using Computational Techniques”. The Protein Journal. 40 (1): 19–27. doi:10.1007/s10930-020-09951-8. PMC 7868315. PMID 33394237.
T3R
The thyroid hormone receptor (TR) is a type of nuclear receptor that is activated by binding thyroid hormone. TRs act as transcription factors, ultimately affecting the regulation of gene transcription and translation. These receptors also have non-genomic effects
Valor LM, Viosca J, Lopez-Atalaya JP, Barco A (2013-07-31). “Lysine acetyltransferases CBP and p300 as therapeutic targets in cognitive and neurodegenerative disorders”. Current Pharmaceutical Design. 19 (28): 5051–5064. doi:10.2174/13816128113199990382. PMC 3722569. PMID 23448461.
TBP
The TBP-associated factors (TAF) are proteins that associate with the TATA-binding protein in transcription initiation. It is a part of the transcription initiation factor TFIID multimeric protein complex. It also makes up many other factors, including SL1.
Chan HM, La Thangue NB (July 2001). “p300/CBP proteins: HATs for transcriptional bridges and scaffolds”. Journal of Cell Science. 114 (Pt 13): 2363–2373. doi:10.1242/jcs.114.13.2363. PMID 11559745.
Blobel GA (2000-02-01). “CREB-binding protein and p300: molecular integrators of hematopoietic transcription”. Blood. 95 (3): 745–755. doi:10.1182/blood.V95.3.745.003k05_745_755. ISSN 1528-0020. PMID 10648382.
Tdg
G/T mismatch-specific thymine DNA glycosylase is an enzyme that in humans is encoded by the TDG gene. Several bacterial proteins have strong sequence homology with this protein.
Dutto I, Scalera C, Prosperi E (April 2018). “CREBBP and p300 lysine acetyl transferases in the DNA damage response”. Cellular and Molecular Life Sciences. 75 (8): 1325–1338. doi:10.1007/s00018-017-2717-4. PMID 29170789. S2CID 3951961.
TFIIB
Transcription factor II B (TFIIB) is a general transcription factor that is involved in the formation of the RNA polymerase II preinitiation complex (PIC) and aids in stimulating transcription initiation.
Newton AL, Sharpe BK, Kwan A, Mackay JP, Crossley M (May 2000). “The transactivation domain within cysteine/histidine-rich region 1 of CBP comprises two novel zinc-binding modules”. The Journal of Biological Chemistry. 275 (20): 15128–15134. doi:10.1074/jbc.M910396199. PMID 10748221.
Chan HM, La Thangue NB (July 2001). “p300/CBP proteins: HATs for transcriptional bridges and scaffolds”. Journal of Cell Science. 114 (Pt 13): 2363–2373. doi:10.1242/jcs.114.13.2363. PMID 11559745.
TFIIE
Transcription factor II E (TFIIE) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex. It is a tetramer of two alpha and two beta chains and interacts with TAF6/TAFII80, ATF7IP, and varicella-zoster virus IE63 protein.
Chan HM, La Thangue NB (July 2001). “p300/CBP proteins: HATs for transcriptional bridges and scaffolds”. Journal of Cell Science. 114 (Pt 13): 2363–2373. doi:10.1242/jcs.114.13.2363. PMID 11559745.
TFIIF
Transcription factor II F (TFIIF) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.
Chan HM, La Thangue NB (July 2001). “p300/CBP proteins: HATs for transcriptional bridges and scaffolds”. Journal of Cell Science. 114 (Pt 13): 2363–2373. doi:10.1242/jcs.114.13.2363. PMID 11559745.
Wrn
The WRN gene provides instructions for producing the Werner protein, which plays a critical role in repairing damaged DNA. The Werner protein functions as a type of enzyme called a helicase. Helicase enzymes generally unwind and separate double-stranded DNA.
Dutto I, Scalera C, Prosperi E (April 2018). “CREBBP and p300 lysine acetyl transferases in the DNA damage response”. Cellular and Molecular Life Sciences. 75 (8): 1325–1338. doi:10.1007/s00018-017-2717-4. PMID 29170789. S2CID 3951961.
Xpa
DNA repair protein complementing XP-A cells is a protein that in humans is encoded by the XPA gene.
Dutto I, Scalera C, Prosperi E (April 2018). “CREBBP and p300 lysine acetyl transferases in the DNA damage response”. Cellular and Molecular Life Sciences. 75 (8): 1325–1338. doi:10.1007/s00018-017-2717-4. PMID 29170789. S2CID 3951961.
Zta (BZLF1)
BZLF1, also known as Zta, EB1, is an immediate-early viral gene of the Epstein–Barr virus (EBV) of the Herpes Virus Family, which induces cancers and infects primarily the B-cells of 95% of the human population.
Newton AL, Sharpe BK, Kwan A, Mackay JP, Crossley M (May 2000). “The transactivation domain within cysteine/histidine-rich region 1 of CBP comprises two novel zinc-binding modules”. The Journal of Biological Chemistry. 275 (20): 15128–15134. doi:10.1074/jbc.M910396199. PMID 10748221.
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