Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen
Abstract HeLa cells contain a serine/threonine protein kinase (DNA-PK) that is strongly activated in vitro by low concentrations of double-stranded DNA (dsDNA). Activation was specific for dsDNA; both natural DNAs and synthetic oligonucleotides functioned as kinase activators. The fact that DNA-PK a
Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. NHEJ is active in both non-dividing and proliferating cells.
Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. It is called “non-homologous” because the break ends are directly ligated without the need for a homologous template, in contrast to homology directed repair (HDR), which requires a&nb
Ku is a dimeric protein complex that binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair
Ku is evolutionarily conserved from bacteria to humans. The ancestral bacterial Ku is a homodimer (two copies of the same protein bound to each other).[2] Eukaryotic Ku is a heterodimer of two polypeptides, Ku70 (XRCC6) and Ku80 (XRCC5), so named because the molecular weight of the human
Ku70
Ku70 is a protein that, in humans, is encoded by the XRCC6 gene.[5][6] Function Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand break ends and is required for the non-homologous end joining (NH
Ku80
Ku80 is a protein that, in humans, is encoded by the XRCC5 gene.[5] Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pat
Big Page of Hazel
The oldest confirmed hazel species is Corylus johnsonii found as fossils in the Ypresian-age rocks of Ferry County, Washington, USA
Frangelico, a brand of noisette known for its unusual packaging
Frangelico is a brand of noisette (flavored with hazelnuts) and herb-flavored liqueur coloured with caramel coloring, which is produced in Canale, Italy. It is 20% alcohol by volume (ABV) or 40 proof. Formerly, it was 24% ABV or 48&nbs
Rhabdomancy is a divination technique which involves the use of any rod, wand, staff, stick, arrow, or the like
One method of rhabdomancy was setting a number of staffs on end and observing where they fall, to divine the direction one should travel, or to find answers to certain questions. It has also been used for divination by arrows (which have wooden shafts) – otherwise known as belomancy. Less
Zinc, maybe
No proof for the need of zinc in human cells was shown until the late 1930s. More than most ever wanted to know about zinc. A work in progress.
The trefoil knot fold is a protein fold in which the protein backbone is twisted into a trefoil knot shape
“Shallow” knots in which the tail of the polypeptide chain only passes through a loop by a few residues are uncommon, but “deep” knots in which many residues are passed through the loop are extremely rare. Deep trefoil knots have been found in the SPOUT superfamily. 
The birds and the bees and the blister beetles
What on earth?
Railroad worms, glowworm beetles and apple maggots
Railroad worm Phengodidae Phrixothrix Scientific classification Domain: Eukaryota Kingdom: Animalia Phylum: Arthropoda Class: Insecta Order: Coleoptera Family: Phengodidae Genus: PhrixothrixOlivier, 1909 Species (several) A railroad worm is a larva or larviform female adult of a beetle of th
Cyanamide notes (it was a polio vaccine that spurred these notes and by now polio has five mentions on the page and these are two of them)
I’m going to add some polio vaccine stuff at the top of these notes. Hilary Koprowski is the one mentioned on the Polio Hall of Fame page who was not included in the hideous monument, see What In God’s Name, even though he (and his work) have direct connection to those who are included.
Basil O’Connor (1892 â 1972) was an American lawyer
In cooperation with U.S. President Franklin D. Roosevelt he started two foundations for the rehabilitation of polio patients and the research on polio prevention and treatment. From 1944 to 1949 he was chairman and president of the American Red Cross and from 1945 to 1950 he was chairman of the Leag
Aliivibrio fischeri (aka Vibrio fischeri), a bioluminescent bacteria and a glowing squid
Aliivibrio fischeri (also called Vibrio fischeri) is a Gram-negative, rod-shaped bacterium found globally in marine environments. This species has bioluminescent properties, and is found predominantly in symbiosis with various marine animals, such as the Hawaiian bobtail squid. It is h
