Effect of biotin deficiency on embryonic development in the domestic fowl (1944) with reference and cited by articles

Avidin and Streptavidin, Biotin, BIRDS, Bugs, Eggs, Reproduction

Effect of biotin deficiency on embryonic development in the domestic fowl (1944) with reference and cited by articles

The approximate biotin requirements of breeding hens have been established and the embryos examined for gross pathological symptoms and the approximate age at death are recorded.
Cravens, W.W., W., & Sebesta, M.A. (1944). Effect of biotin deficiency on embryonic development in the domestic fowl. The Anatomical Record, 90.

Reference articles

Effect of Biotin on Reproduction in the Domestic Fowl

1942

Summary Evidence is presented to show that biotin is essential for normal embryonic development in the hen’s egg. A satisfactory synthetic ration for use in studies of the vitamin requirements of…

XI.—Studies in Embryonic Mortality in the Fowl. II. Chondrodystrophy in the Chick.

1930

TLDR

It is shown that the incidence of chondrodystrophy appears to be inversely proportional to the amount of sunshine, and the suggestion is made that lack of direct sunlight is a factor in the etiology of the abnormality.

Influence of riboflavin‐deficiency in eggs on embryonic development (gallus domesticus)

1942

TLDR

It has been demonstrated (Lepkovsky, Taylor, Jukes and Almquist, ’38; and others) that low hatchability of riboflavin-deficient eggs can be completely restored by either oral feeding or by subcutaneous injection of crystalline riboflavin.

CHOLINE IN THE NUTRITION OF CHICKS

1941
PDF

The effects of vitamin‐E deficiency on the development of the chick

1931

In an investigation of the hatchability of eggs from hens fed on a diet deficient in vitamin E Card found that all embryos from these eggs died during development. Study of these chicks showed that a…

Chondrodystrophia in chicken embryos.

1926

TLDR

During the routine examination of chick embryos which had died during incubation, in 1923 several embryos exhibiting a striking abnormality resembling the condition known in mammals as Chondrodystrophia foetais (Kaufman) are reported for the first time in bird embryos.

The effect of riboflavin and the filtrate factor on egg production and hatchability

1938

TLDR

It is suggested that more than one factor in the vitamin-G complex is involved in hatchability of eggs, and the term “vitamin G” as previously used in the literature covered the complex action of several vitamins.

The effect of abnormal temperatures upon the developing nervous system in the chick embryos

1919

TLDR

Las conclusiones obtenidas por el presente trabajo son las siguientes: El calor excesivo y una limitada cantidad de calor producen the muerte de muchos embriones de gallina y da,n lugar a varias formas of anormalidades en el sistema nervioso de otros.

A LETHAL EMBRYONIC WING MUTATION IN THE DOMESTIC FOWL

1943

HEREDITARY CHONDRODYSTROPHY IN THE FOWL

1942

Skeletal abnormalities in the offspring of rats reared on deficient diets

1941

BANTAM GENETICS Distribution of Traits in a Sebright-Mille Fleur Cross

1929

An Hereditary Complex in the Domestic Fowl.

1919

Experimental production of congenital skeletal abnormalities in offspring of rats fed a deficient diet.

1942

Chondrodystrophy in the chick embryo produced by manganese deficiency in the diet of the hen.

1937

The effect of cod liver oil in the diet of the mother hen, on embryo mortality and on the calcium and phosphorus content of the embryo.

1936

Cited by articles

The effect of folio acid on embryonic_development of the domestic fowl.

1950

TLDR

Data is presented showing the effect on hatchability of injecting folic acid into the egg in varying quantities and at different times of incubation and the relation between the type of carbohydrate in the diet and the incidence of abnormal embryos.

Relation of biotin to congenital deformities in the chick

1948

TLDR

The relationship of biotin to the incidence of perosis and other congenital anomalies in the chick was determined and the skeletal deformities observed by the above workers were studied in detail.

Nutrition and embryonic development in the domestic fowl

1975

TLDR

Turkey embryos from eggs laid by turkey hens fed on a diet deficient in pantothenic acid live to the end of the 28th day, but do not pip the shell; these embryos are decreased in sue, have a wiry type of stiff down, and cannot be relieved by biotin injection.

Nutrition and reproduction in the domestic fowl

1960

TLDR

Some of the effects of individual nutritional deficiencies on embryonic development are proposed, with special emphasis on the age at death of the embryo and the occurrence of specific abnormalities.

Effect of Supplemental Biotin on Reproductive Performance of Turkey Breeder Hens and its Effect on the Subsequent Progeny’s Performance

1971

TLDR

The studies reported herein were conducted to determine the effect of supplemental biotin on reproductive performance of turkey breeder hens and to determine if egg production and hatchability were improved by biotin supplementation in diets of turkey Breeder Hens.

The Effect of Diet and Cecectomy on the Intestinal Synthesis of Biotin in Mature Fowl

1950

TLDR

Preliminary investigations made in an attempt to establish the site of synthesis revealed that the ceca contained about ten times as much biotin and two times asMuch riboflavin and niacin as the duodenum loop, the small intestine, or the feces excreted.

Teratogenic effects of avidin-induced biotin deficiency in mice.

1984

TLDR

It is suggested that biotin is important for early embryonic development in the mouse with a considerable increase of fetuses with multiple congenital malformations with increasing amounts of avidin.

The Effect of the Injection of Biotin and Insulin on Congenital Deformities in the Chick

1949

TLDR

The present investigation was initiated to determine whether the anomalies resulting from the injection of 5 units of insulin per egg at 120 hours of incubation could be prevented by a single injection of biotin prior to the start of the incubation period.

Roles of biotin in growing ovarian follicles and embryonic development in domestic fowl.

2007

TLDR

Findings show that biotin is an essential nutrient and may play a major role in the normal morphogenesis of embryos in domestic fowl.

Study on Teratogenicity of Biotin Deficiency in Mice at Midgestation

2007

TLDR

It is suggested that biotin is an essential nutrient and may play an important role in reproductive perfor‑ mance and the transportation of biotin to embryos differed among embryonic growth periods and organs and biotin may play a principal role in the form of tissues and organs.

VITAMIN DEFICIENCIES AND ANTAGONISTS

1952

TLDR

The experiments with biotin do not involve the use of antimetabolites but will serve to show the effect of inadequate maternal nutrition on embryonic development and to point out the limitations of this approach to the study of biochemical defects in the chick embryo arising from a nutritional deficiency.

Effects of maternal nutrition on hatchability.

1997

TLDR

The effects of dietary factors on the development and viability of avian embryos have been extensively documented and it is common for the effects on the embryo to also become more severe and to occur at earlier stages of development.

The Pteroylglutamic Acid Requirement of Laying and Breeding Hens

1950

Abstract AFTER pteroylglutamic acid (P.G.A., folic acid) became available in sufficient quantities for experimental work, Taylor (1947), Schweigert, et al., (1948) and Cravens and Halpin (1949) have… Expand

Morphological and biochemical effects of excessive amounts of biotin on embryonic development in mice

2005

TLDR

It was concluded that excessive amounts of biotin affected the specific activity of Biotinidase in pregnant mice, but did not disturb normal reproductive functions and embryonic development.

Relationship of biotin to reproductive performance of Leghorn-type hens.

1976

TLDR

Fertility and hatchability were both significantly improved by biotin supplementation, and differences were found to be highly significant by chi-square analyses.

The relationship of cleft palate to riboflavin deficiency and genotype in chickens

1973

TLDR

The cleft palate condition was shown to be semi-lethal, the lethality being partially due to severe expression of the trait .

Influence of egg storage on hatchability, embryonic development and vitamin status in hatching broiler chicks.

1985

TLDR

Biochemical and haematological data did not suggest impairments in the status of the chicks with respect to a range of other vitamins, and storage of eggs for 14 d prior to incubation depressed hatchability.

Effect of biotin on dermatitis and hatchability in dwarf and normal size single comb white leghorn layers.

1984

TLDR

Hatchability was satisfactory in both types of layers, and it was significantly higher in the dwarfs, which is contrary to what would be expected if they had suffered from a biotin deficiency.

PRODUÇÃO ANIMAL TRACE MINERALS AND AVIAN EMBRYO DEVELOPMENT

2002

It is essential that breeder diet be adequate in all nutrients so that the embryo inside the egg can develop normally. When a deficiency or toxicity of trace mineral occurs and egg hatchability is…

Biotin deficiency and biotin excess: Effects on the female reproductive system

2009

A treatise on chicken dam nutrition that impacts on progeny

2003

TLDR

This paper is concerned with breeder hen nutrition as a means to improve chick quality and specific ingredients and nutrients fed to hens that influence progeny growth, carcass attributes, enzyme functions, and immunity are discussed.

1 Excerpt

Micronutrients and Congenital Anomalies *

1990

TLDR

It was demonstrated that maternal biotin deficiency produced a high incidence of external and skeletal malformations in mice, although the dams showed no clinical signs ofBiotin deficiency during gestation, and the formation of secondary palatal processes and limb buds was delayed at midgestation in these biotin‐deficient mouse embryos, probably leading later to cleft palate and limb malforms.

Involvement of biotin in the fatty liver and kidney syndrome of broilers.

1974

TLDR

With these wheat‐meat meal diets biotin concentrations of up to 120 μg/kg diet were associated with FLKS mortality but when the biotin concentration was raised to 145 μg/, growth was maximised and mortality due to FLKS eliminated and there was evidence that the concentration of biotin levels in breeder diets may affect the incidence of FLKS in their progeny.

MALFORMATIONS EMBRYONNAIRES D’ORIGINE CARENTIELLE

1954

The early development of an organism is a critical stage which many factors may influence unfavourably. Maternal nutritional deficiencies, especially vitamin deficiencies, can disturb the development…

Prenatal Treatment of Multiple Carboxylase Deficiency

1985

TLDR

In view of the eminently treatable nature of in utero treatment, coupled with current prenatal diagnostic techniques has become a very exciting prospect.

Biochemical and Molecular Actions of Nutrients Marginal Biotin Deficiency Is Teratogenic in ICR Mice

2003

TLDR

It is concluded that in ICR mice, marginal maternal biotin deficiency causes fetalBiotin deficiency, and it is speculated that some human fetal malformations may be caused by Biotin deficiency.Expand

Save

Effect of supplementary biotin on performance of turkeys fed corn-soybean meal type diets.

1969

TLDR

The biotin content of the egg white or yolk was highly responsive to the amount of biotin in the diet and upon apparent intestinal synthesis, and Waibel et al. (1952) found that dietary penicillin resulted in increased deposition ofBiotin and folic acid in egg yolk.Expand

Save

Marginal Biotin Deficiency is Teratogenic (44458)

2000

TLDR

Analysis of data from a published multivitamin supplementation study provides significant albeit indirect evidence that the marginal degree of biotin deficiency that occurs spontaneously in normal human gestation is teratogenic and investigation of potential mechanisms provides evidence that biotin transport by the human placenta is weak.ExpandSave

Studies on the biotin requirement of broiler breeders.

1972

TLDR

The egg biotin level, which produced maximum hatchability and livability of chicks, corresponding to the estimated minimum requirement of 100 μg.Expand

Save

Transplacental transport and tissue distribution of biotin in mice at midgestation

2008

TLDR

It is suggested that biotin is an essential nutrient and may play an important role in embryonic growth and the mechanism of biotin transport from dams to embryos is elucidated.

Marginal biotin deficiency is teratogenic.

2000

TLDR

Interactions entre la biotine et l’avidine dans la nutrition du poisson zèbre Danio rerio (Hamilton-Buchanan)

2012

TLDR

The results of this thesis constitute a baseline in the understanding of the interactions between dietary biotin and avidin in zebrafish nutrition and in the potential use of these interactions in order to develop a biological confinement strategy of farmed fish on the other hand.

Availability of avidin-bound biotin to the chicken embryo.

1992

Centennial Review: Trace mineral research with an emphasis on manganeseDedicated to Dr. Roland M. Leach, Jr.

2021
PDF

The effects of the dietary biotin on zebrafish Danio rerio reproduction

2015

TLDR

The results confirmed that delayed spermato-genesis and decreased number of spermatozoa inrats were also attributed to biotin deﬁciency, which was found to decrease the fertility of fruit.

Biotin requirements of broiler breeders fed diets of different protein content and effect of insufficient biotin on the viability of progeny.

1985

TLDR

Production of eggs or normal chicks was depressed when practical diets containing 168 g or 137 g of crude protein (CP)/kg were not supplemented with synthetic biotin and chicks from young hens fed insufficient biotin had the poorest biotin status at hatching.

Studies on the biotin requirement of broilers fed sunflower seed meal based diets.

1994

TLDR

Estimation of the live weights, live weight gain, feed intake, blood glucose and free fatty acid concentrations, lipid contents and weights of liver and kidney, and liver pyruvate carboxylase activity indicated that in the case of dehulled SSM, dietary biotin of of 160 mcg/kg feed was marginal while at least 200 mcG/kg appeared to be needed for optimum performance of the birds.

Responses of broilers fed guineacorn/palm kernel meal based ration to supplemental biotin

1991

TLDR

Responses of experimental birds indicated that a dietary supplement of 0·20 mg biotin kg – 1 feed was adequate for the promotion of good performance and the prevention of dermal lesions, FLKS mortality and leg deformities.

The hidden function of egg white antimicrobials: egg weight-dependent effects of avidin on avian embryo survival and hatchling phenotype

2018

TLDR

It is suggested that an increase in egg white avidin favours embryo survival in lighter eggs during late embryogenesis, but at the expense of reduced structural body size.

1 Excerpt

Current knowledge on biotin nutrition in fish and research perspectives

2015

TLDR

A comparative analysis of current knowledge on biotin physiology and nutritional biochemistry in terrestrial and aquatic animal nutrition is provided in order to plan further studies.

Biotin decreases retinal apoptosis and induces eye malformations in the early chick embryo

2002

TLDR

The results suggest that an adequate content of biotin and a precise regulation of retinal cell death are required for the correct morphogenesis of the eye.

Abstract Proliferation, cell death and differentiation occur simultaneously in developing retina and are precisely orchestrated. We have studied the effects of biotin (vitamin H) on early retinal development. In vivo administration of biotin to early embryonic chick eyes at moderately elevated levels induced malformations, affecting retina and lens structures. The effects were strictly age dependent and were only found in embryos treated between Hamburger and Hamilton stage 14–17. Biocytin, a biotin analogue, mimicked biotin effects, while avidin could block the effects. At the cellular level, biotin did not affect proliferation but reduced apoptosis. These results suggest that an adequate content of biotin and a precise regulation of retinal cell death are required for the correct morphogenesis of the eye.

Human placental biotin transport: normal characteristics and effect of ethanol.

1993

TLDR

It is concluded that the overall (maternal-fetal) rate-limiting transfer of biotin by the human placenta is most consistent with a passive process, which is not inhibited by short-term exposure to ethanol.

Abstract Biotin, a vitamin essential for many metabolic reactions, is supplied to the fetus exclusively from the mother. Deficiency of biotin in pregnancy leads to impaired fetal growth and development. Alcohol taken in pregnancy likewise may cause fetal growth abnormalities. Normal biotin transport via the placenta and the effects of ethanol on this transport apparently have not been studied. Our aims were to characterize these phenomena for the normal human-term placenta. Using maternal-facing placental membrane vesicles, biotin uptake was sodium- and temperature-dependent, saturable, and inhibited by structural analogs of biotin (desthiobiotin, biocytin, and biotin methyl ester), as well as by 4 and 10 hr exposure to 3 g/liter ethanol. Using the isolated perfused single cotyledon method to measure placental transport of biotin at a perfusion concentration of 1 nM, the overall rate of biotin transport was found to be only 30% that of antipyrine, a freely diffusible marker. Clearance of biotin was approximately 2 ml/hr.g placenta, which was equal to the clearance of passively transferred L-glucose; biotin clearance was similar in both maternal to fetal and fetal to maternal directions. Overall transfer of biotin from maternal to fetal compartments was not inhibited by 500-fold greater concentrations of the three analogs, did not proceed against a biotin concentration gradient, and was not inhibited by 90-240 min exposure to an initial concentration of 4 g/liter ethanol. Concentration of biotin in the fetal compartment at the end of the study was not higher than on the maternal side (after maternal to fetal infusion), but placental concentration was 2- to 3-fold greater. No significant metabolism of biotin was detected. Exposing human placental cultured trophoblast on day 3 to 24 hr of ethanol (2 g/liter) had no effect on the net uptake of biotin by these cells. These studies provide evidence that maternal-facing placental membranes take up biotin by a mediated, carrier-dependent process that is inhibited by ethanol; however, based on the perfusion studies, we conclude that the overall (maternal-fetal) rate-limiting transfer of biotin by the human placenta is most consistent with a passive process, which is not inhibited by short-term exposure to ethanol.

Physiology and biochemistry of biotin.

1960

Biotin deficiency decreases life span and fertility but increases stress resistance in Drosophila melanogaster.

2004
PDF

2 Excerpts

Abstract Biotin deficiency is associated with fetal malformations and activation of cell survival pathways in mammals. In this study we determined whether biotin status affects life span, stress resistance, and fertility in the fruit fly Drosophila melanogaster. Male and female flies of the Canton-S strain had free access to diets containing 6.0 (control), 4.8, 2.5, or 0 pmol biotin/100 mg. Biotin concentrations in diets correlated with activities of biotin-dependent propionyl-CoA carboxylase and biotin concentrations in fly homogenates, but not with biotinylation of histones (DNA-binding proteins). Propionyl-CoA carboxylase activities and biotin concentrations were lower in males than in females fed diets low in biotin. The life span of biotin-deficient males and females was up to 30% shorter compared to biotin-sufficient controls. Exposure to oxidative stress reversed the effects of biotin status on survival in male flies: survival times increased by 40% in biotin-deficient males compared to biotin-sufficient controls. Biotin status did not affect survival of females exposed to oxidative stress. Exposure of flies to cold, heat, and oxidative stress was associated with mobilization of biotin from yet unknown sources. Biotin deficiency decreased fertility of flies. When biotin-deficient males and females were mated, the hatching rate (larvae hatched per egg) decreased by about 28% compared to biotin-sufficient controls. These findings are consistent with the hypothesis that biotin affects life span, stress resistance, and fertility in fruit flies.

MICROALGAE AND ZINC SOURCE SUPPLEMENTATION OF BROILER BREEDER DIETS AFFECTS BROILER BREEDER SKELETAL DEVELOPMENT AND REPRODUCTION WITH TRANSGENERATIONAL IMPACTS ON OFFSPRING PERFORMANCE AND SKELETAL CHARACTERISTICS

2019

TLDR

Dietary microalgae supplementation in broilers breeder diets improved early bone development in broiler breeders, early bone Development in broiling breeder offspring, and hatchability of offspring during post-peak lay.

1 Excerpt

TRACE MINERALS AND AVIAN EMBRYO DEVELOPMENT

2006

TLDR

Deve ser uma pratica-padrao para as granjas de reprodutores a continua avaliacao dos suplementos minerais e vitaminicos usados para assegurar a sua qualidade.