Quadrigen (DPT combined with the Salk polio vaccine) – random notes

In 1959, the Parke-Davis Quadrigen vaccine (DPT combined with the Salk polio vaccine) is licensed. The vaccine is alleged to be particularly reactive because of the effect of the preservative on the pertussis component. Several lawsuits ensue. The vaccine is withdrawn from the market in 1968 (Coulter and Fisher, 1985).

Institute of Medicine (US) Committee to Review the Adverse Consequences of Pertussis and Rubella Vaccines; Howson CP, Howe CJ, Fineberg HV, editors. Adverse Effects of Pertussis and Rubella Vaccines: A Report of the Committee to Review the Adverse Consequences of Pertussis and Rubella Vaccines. Washington (DC): National Academies Press (US); 1991. B, Pertussis and Rubella Vaccines: A Brief Chronology. Available from: https://www.ncbi.nlm.nih.gov/books/NBK234365/

References

1. Institute of Medicine (US) Committee to Review the Adverse Consequences of Pertussis and Rubella Vaccines; Howson CP, Howe CJ, Fineberg HV, editors. Adverse Effects of Pertussis and Rubella Vaccines: A Report of the Committee to Review the Adverse Consequences of Pertussis and Rubella Vaccines. Washington (DC): National Academies Press (US); 1991. B, Pertussis and Rubella Vaccines: A Brief Chronology. Available from: https://www.ncbi.nlm.nih.gov/books/NBK234365/
2. January 12, 1967. Clin-Alert. 1967;5(1):1-4. doi:10.1177/006947706700500101