HFE H63D & VO2 max
SMOKE EM IF YOU GOT EM The HFE H63D is a single-nucleotide polymorphism in the HFE gene (c.187C>G, rs1799945), which results in the substitution of a histidine for an aspartic acid at amino acid position 63 of the HFE protein (p.His63Asp). HFE participates in the regulation of iron absorption.
Transferrin binding and PH
Transferrin binding to transferrin receptors reduces its affinity for iron. Two pathways can occur once endocytosed–degradation or recycling pathways. The degradation pathway is where the dissociation of ferric ions from transferrin occurs from an early and late endosome. Iron can now be utilized
Freemartin
A freemartin or free-martin (sometimes martin heifer) is an infertile female cattle with masculinized behavior and non-functioning ovaries.[1] Phenotypically, the animal appears female, but various aspects of female reproductive develo
Skanda Home
what on Earth Little things make big days. Non blandit massa enim nec dui nunc mattis. Montes nascetur ridiculus mus mauris vitae ultricies. Feugiat nibh sed pulvinar proin gravida hendrerit lectus. Nunc scelerisque viverra mauris in aliquam sem. Pretium viverra suspendisse potenti nullam ac tortor
Connection (and difference) between buccal membrane and buccopharyngeal membrane
A Tale of Two Tissues Prepare yourself for a thrilling journey into the world of microscopic membranes! Today, we’re diving deep into the oral cavity to explore the buccal membrane and its embryonic cousin, the buccopharyngeal (aka oropharyngeal) membrane. It’s a story of similarities, d
Buccal Administration of Insulin
Nanotechnology as a Promising Strategy for Alternative Routes of Insulin Delivery Catarina Pinto Reis, Christiane Damgé, in Methods in Enzymology, 2012 Chapter fourteen The buccal mucosa has excellent accessibility, low enzymatic activity, a large absorptive area with a spread of vasc
embryonic intrigue that’ll make your buccopharyngeal membrane quiver with excitement!
Picture, if you will, the humble beginnings of life, where a thin membrane known as the buccopharyngeal membrane (or oropharyngeal membrane for those who like their words extra fancy) plays the role of the ultimate gatekeeper between the primitive mouth and pharynx. It’s like nature’s ve
Rete pegs (aka rete processes or rete ridges or papillae) are epithelial extensions that project into the underlying connective tissue in both skin and mucous membranes.
In the epithelium of the mouth, the attached gingiva exhibit rete pegs, while the sulcular and junctional epithelia do not. Scar tissue lacks rete pegs and scars tend to shear off more easily than normal tissue as a result. Ira D. Papel (2011). Facial Plastic and
Thermolysin – The Tiny Terminator of Plasma Proteins!
Both thermolysin and snake venom metalloproteinases (SVMPs) share a similar mechanism of action, utilizing zinc ions to hydrolyze peptide bonds in proteins
Pituri, aka mingkulpa, is a mixture of leaves and wood ash traditionally chewed as a stimulant (or, after extended use, a depressant) by Aboriginal Australians widely across the continent.
Leaves are gathered from any of several species of native tobacco (Nicotiana) or from at least one distinct population of the species Duboisia hopwoodii. Various species of Acacia, Grevillea and Eucalyptus are burned to produce the ash. The term “pituri” may also refer to the plant
The term “hormesis” derives from Greek hórmēsis for “rapid motion, eagerness”, itself from ancient Greek hormáein to excite. The same Greek root provides the word hormone.
Hormesis is a two-phased dose-response relationship to an environmental agent whereby low-dose amounts have a beneficial effect and high-dose amounts are either inhibitory to function or toxic. Within the hormetic zone, the biological response to low-dose amounts of some stressors is generall
Arsenic: The Element of Surprise (and Murder)
Let’s dive into the sordid history of arsenic, the “King of Poisons” and the “Poison of Kings.” Our story begins in ancient times, when alchemists were busy trying to turn lead into gold. Little did they know, they were playing with fire – or rather, arsenic. Thes
Baruch Samuel Blumberg (1925 – 2011), aka Barry Blumberg, was an American physician, geneticist, co-recipient of the 1976 Nobel Prize in Physiology or Medicine (with Daniel Carleton Gajdusek), for his work on the hepatitis B virus. He was also the first director of NASA Astrobiology Institute.
He was also president of the American Philosophical Society from 2005 until his death. Blumberg and Gajdusek received the Nobel Prize for discovering “new mechanisms for the origin and dissemination of infectious diseases.” Blumberg identified the hepatitis B virus, and later develo
Daniel Carleton Gajdusek (1923 – 2008) was an American physician and medical researcher who was the co-recipient (with Baruch S. Blumberg) of the Nobel Prize in Physiology or Medicine in 1976 for work on the transmissibility of kuru, implying the existence of an infectious agent, which he named an ‘unconventional virus’.
His papers are held at the National Library of Medicine in Bethesda, Maryland and at the American Philosophical Society in Philadelphia, Pennsylvania. Early life and education Gajdusek’s father, Karol Gajdusek, was a Slovak butcher from Smrdáky, Kingdom of Hungary, now S
The first hepatitis B vaccine was approved in the United States in 1981. A recombinant version came to market in 1986. Both versions were developed by Maurice Hilleman and his team. (a history of hepatitis B vaccine)
Preliminary work In 1963, the American physician/geneticist Baruch Blumberg, working at the Fox Chase Cancer Center, discovered what he called the “Australia Antigen” (HBsAg) in the serum of an Australian Aboriginal person. In 1968, this protein was found to be part of the virus that
Wolf Szmuness, epidemiologist and former roommate of a future Pope John Paul II, is named in an AIDS origin theory involving his hepatitis B vaccine trials
Wolf Szmuness (1919 – 1982) was a Polish-born epidemiologist who emigrated to and worked in the United States. He conducted research at the New York Blood Center and, from 1973, he was director of the Center’s epidemiology laboratory. He designed and conducted the trials for the first