Introduction to ADAMTS2

ADAMTS2 is an enzyme primarily concentrated in skin and connective tissues. It plays a crucial role in processing procollagen, which is essential for collagen formation and maintenance. Collagen is a structural protein that contributes to the integrity and repair of tissues. The activity of ADAMTS2 highlights its significance in tissue repair, integrity, and overall structure.

Snake Venom Connection

ADAMTS2, like other members of the ADAM and ADAMTS family, shares structural similarities with snake venom metalloproteinases (SVMPs). These proteins are part of the same family of metalloproteinases known as adamalysins or reprolysins. Here are some key points about the connection between ADAMTS2 and snake venom:

Key Points of Connection:

Structural Similarity: ADAMTS2 and SVMPs have a modular structure with multiple non-catalytic ancillary domains. This structural similarity highlights their evolutionary relationship.

Function: Both ADAMTS2 and SVMPs are involved in proteolytic activities. SVMPs are primarily responsible for hemorrhagic activity and can interfere with the hemostatic system in envenomed animals. ADAMTS2, on the other hand, plays a role in collagen processing and extracellular matrix remodeling.

Phylogenetic Relationship: SVMPs are phylogenetically most closely related to ADAMs. Together with ADAMs and ADAMTS proteins, they constitute the M12B clan of metalloproteinases.

This connection underscores the diverse roles that these proteins play in both physiological and pathological processes, from normal cellular functions to the potent effects of snake venom.

ADAMTS2 Tissue Distribution by Expression Level

Adrenal Gland: 81

Bone Marrow: 81

Cerebellum: 81

Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma: 81

Gallbladder: 81

Hippocampal Formation: 81

Placenta: 81

Stomach: 81

Vagina: 81

Colon: 78

Endometrium: 78

Midbrain: 78

Lymph Node: 78

NK-cells & T-cells: 78

Retina: 78

Salivary Gland: 78

Smooth Muscle: 78

Urinary Bladder: 78

Amygdala: 72

Breast: 72

Heart Muscle: 72

Pancreas: 72

Pituitary Gland: 72

Rectum: 72

Testis & Skeletal Muscle: 72

Thymus: 72

Cerebral Cortex: 70

Liver: 70

Ovary: 70

Parathyroid Gland: 70

Seminal Vesicle: 70

Skin: 70

Spermatocytes & Spermatids: 70

Spleen: 70

Tongue: 70

Hypothalamus: 67

Lymphoid Tissue & Bone Marrow: 67

Basal Ganglia: 54

Cervix: 54

Choroid Plexus: 54

Duodenum: 54

Kidney: 54

Lung: 54

Lymphatic Endothelial Cells: 54

Tonsil: 54

Proximal Tubular Cells: 38

Adipose Tissue: 38

Appendix: 38

Esophagus: 38

Fallopian Tube: 38

Prostate: 38

Small Intestine: 38

Spinal Cord: 38

Thyroid Gland: 38

Monocytes & Neutrophils: 37

You can find more detailed information and numerical data on the Human Protein Atlas.