Antithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01)

January 3, 2023

Antiplatelet drugs	Glycoprotein IIb/IIIa inhibitors Abciximab Eptifibatide Orbofiban Roxifiban Sibrafiban^§Tirofiban ADP receptor/P2Y₁₂ inhibitors Thienopyridines Clopidogrel Prasugrel Ticlopidine Nucleotide/nucleoside analogs Cangrelor Elinogrel Ticagrelor Prostaglandin analogue (PGI2) Beraprost Iloprost Prostacyclin Treprostinil COX inhibitors Acetylsalicylic acid/Aspirin^# Aloxiprin Carbasalate calcium Indobufen Triflusal Thromboxane inhibitors Thromboxane synthase inhibitors Dipyridamole (+ aspirin) Picotamide Terbogrel Receptor antagonists Terbogrel Terutroban^§ Phosphodiesterase inhibitors Cilostazol Dipyridamole Triflusal Other Cloricromen Ditazole Vorapaxar

^#WHO-EM^‡Withdrawn from marketClinical trials: ^†Phase III^§Never to phase III

Anticoagulants	Vitamin K antagonists (inhibit II, VII, IX, X) Coumarins: Acenocoumarol Coumatetralyl Dicoumarol Ethyl biscoumacetate Phenprocoumon Warfarin^#1,3-Indandiones: Clorindione Diphenadione Phenindione Other: Tioclomarol Factor Xa inhibitors (with some II inhibition) Heparin group/ glycosaminoglycans/ (bind antithrombin) Low-molecular-weight heparin Bemiparin Certoparin Dalteparin Enoxaparin Nadroparin Parnaparin Reviparin Tinzaparin Oligosaccharides Fondaparinux Idraparinux^§ Heparinoids Danaparoid Dermatan sulfate Sulodexide *Direct Xa inhibitors (“xabans”)* Apixaban Betrixaban Darexaban^§ Edoxaban Otamixaban^§ Rivaroxaban Direct thrombin (IIa) inhibitors Bivalent: Hirudin Bivalirudin Desirudin Lepirudin^‡ Univalent: Argatroban Dabigatran Efegatran Inogatran^§ Melagatran^‡ Ximelagatran^‡ Other Antithrombin III Defibrotide Nafamostat Protein C Drotrecogin alfa^‡ Ramatroban REG1

Vitamin K antagonists
(inhibit II, VII, IX, X) Coumarins: Acenocoumarol Coumatetralyl Dicoumarol Ethyl biscoumacetate Phenprocoumon Warfarin^#1,3-Indandiones: Clorindione Diphenadione Phenindione Other: Tioclomarol Factor Xa inhibitors
(with some II inhibition) Heparin group/
glycosaminoglycans/
(bind antithrombin) Low-molecular-weight heparin Bemiparin Certoparin Dalteparin Enoxaparin Nadroparin Parnaparin Reviparin Tinzaparin Oligosaccharides Fondaparinux Idraparinux^§ Heparinoids Danaparoid Dermatan sulfate Sulodexide Direct Xa inhibitors (“xabans”) Apixaban Betrixaban Darexaban^§ Edoxaban Otamixaban^§ Rivaroxaban Direct thrombin (IIa) inhibitors Bivalent: Hirudin Bivalirudin Desirudin Lepirudin^‡ Univalent: Argatroban Dabigatran Efegatran Inogatran^§ Melagatran^‡ Ximelagatran^‡ Other Antithrombin III Defibrotide Nafamostat Protein C Drotrecogin alfa^‡ Ramatroban REG1

^#WHO-EM^‡Withdrawn from marketClinical trials: ^†Phase III^§Never to phase III

Thrombolytic drugs/ fibrinolytics	Plasminogen activators: r-tPA Alteplase^# Reteplase Tenecteplase Desmoteplase^† UPA Saruplase Urokinase Anistreplase Monteplase Streptokinase^# Other serine endopeptidases: Ancrod^‡ Brinase Fibrinolysin
Non-medicinal	Citrate EDTA Oxalate

^#WHO-EM^‡Withdrawn from marketClinical trials: ^†Phase III^§Never to phase III Highlight indicates local pages exist

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