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Addition in pharmacological active compounds

Several variants of pi coordinated phenyls have even been tested using transition metals for stacking η6-phenyltropanes, using cyclopentadienyl and tricarbonyl in place of a benzene. Which in the case of the tricarbonyl doubled the compound’s affinity for its intended ligand site (posited as due to resultant electrostatic influences being more conducive to the target).

  • Singh S (March 2000). “Chemistry, design, and structure-activity relationship of cocaine antagonists”. Chemical Reviews. 100 (3): 925–1024. doi:10.1021/cr9700538PMID 11749256.
Chemical structure of cocaine analog 21b

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