Sound-induced convulsions in the hamster associated with magnesium deficiency (1947)

Exposure of 16 hamsters maintained on an Mg deficient diet, 10 animals placed on a control diet immediately after a first convulsive attack, 10 Mg-deficient animals given Mg supplements after each induced convulsion, and 12 control animals maintained on adequate purified diet, to sound tests, indicated results similar to those reported for the rat. Spontaneous convulsions occurred in the Mg-deficient animals after from 7 to 20 days of Mg deprivation. Administration of Mg protected animals against induced seizures. The average survival time of the deficient animals was 20 days, death being due to the effects of either sound-induced or spontaneous convulsions. Deficient animals restored to a normal diet appeared normal within 4 days.

PATTON RA. Sound-induced convulsions in the hamster associated with magnesium deficiency. J Comp Physiol Psychol. 1947 Aug;40(4):283-9. doi: 10.1037/h0055819. PMID: 20260240.

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