š§¬ How PTH (and vitamin D supplementation) Can Mask Sodium Deficiency
PTH imbalances can mask or mimic sodium depletion symptoms, especially in chronic terrain collapse. Letās unpack how this works glyphically and biochemically: š§ Diagnostic Mimicry: PTH vs. Sodium Deficiency ā” Shared Symptoms Both chronic sodium deficiency and parathyroid hormone (PTH) imbalan
The Other SCN (Suprachiasmatic Nucleus) and the connection to SCN- (thiocyanate)
These two entities share the same abbreviation (SCN), yet reside in vastly different terrains: one biochemical (thiocyanate), the other neuroanatomical (suprachiasmatic nucleus). Letās explore whether they intersect, metaphorically or materially. š§Ŗ SCNā»: Thiocyanate š§ SCN: Suprachiasmatic
š§¬ What Is Beta-Glucuronidase?
Beta-glucuronidase (Ī²G) is a lysosomal enzyme that catalyzes the hydrolysis of glucuronidesāmeaning it breaks apart compounds that have been conjugated with glucuronic acid during Phase II liver detoxification. It is the undoer of the covenantāthe enzyme that breaks the seal. Sources of Beta-Gl
Chalone Rangers: The Tissue-Specific Mitotic Inhibitors You Never Knew You Needed
Chalones are the unsung heroes of cellular crowd control. These tissue-specific, water-soluble substances are like the bouncers of your body, standing at the gates of mitosis with their arms crossed, saying, āNot tonight, buddy.ā Theyāre the biochemical equivalent of that one friend who knows
Autacoids Unleashed: The Self-Made, Self-Destructive Hormones You Didnāt Know You Needed
What Are Autacoids? Autacoids (or autocoids) are the bodyās DIY hormonesālocally produced, short-lived biochemical messengers that scream, āI got this!ā before promptly fading into oblivion. The term comes from the Greek autos (self) and acos (relief or drug), which is ir
Snake Venom: The Hormone Hijacker š
Imagine a villainous mastermind that can infiltrate your body’s hormonal headquarters, manipulating the delicate balance of estrogen and other hormones. Welcome to the world of snake venom, where the stakes are high and the effects are unpredictable. Estrogen’s Uninvited Guest: When Snak
Relaxin
We’re about to dive into the wild world of Relaxin, the protein hormone that’s been turning heads since 1926 when Frederick Hisaw first stumbled upon it. This isn’t your average hormone – it’s a multitasking marvel that’s about to blow your mind! Researchers say t
The term “hormesis” derives fromĀ GreekĀ hĆ³rmÄsisĀ for “rapid motion, eagerness”, itself from ancient GreekĀ hormĆ”einĀ to excite.Ā The same Greek root provides the wordĀ hormone.
HormesisĀ is a two-phasedĀ dose-response relationshipĀ to an environmental agent whereby low-dose amounts have a beneficial effect and high-dose amounts are either inhibitory to function or toxic.Ā Within theĀ hormetic zone, the biological response to low-dose amounts of someĀ stressorsĀ is generall
Oxytocin: The Molecular Maestro of Love and Labor
Buckle up, hormone enthusiasts! We’re about to take a wild ride into the world of oxytocin, the “love hormone” that’s been playing Cupid in our bodies since the dawn of mammalian evolution. This tiny peptide packs a punch that would make even Hercules jealous! Picture this: a
Eraso Y. Biotypology, endocrinology, and sterilization: the practice of eugenics in the treatment of Argentinian women during the 1930s. Bull Hist Med. 2007 Winter;81(4):793-822. doi: 10.1353/bhm.2007.0130. PMID: 18084107; PMCID: PMC2629848.
SUMMARYThis article looks at medical approaches to womenās fertility in Argentina in the 1930s and explores the ways in which eugenics encouraged the reproduction of the fit and attempted to avoid the reproduction of the unfit. The analysis concentrates on three main aspects: biotypology (the scie
the hormone hustle
We’re about to embark on a time-traveling, mind-bending journey through the evolution of normalization, biopolitics, and the wild world of hormones. From Foucault’s philosophical bombshells to Nicola Pende’s hormone-fueled science experiments, this is a story that will leave y
Beccalossi C. Sexology, sexual development, and hormone treatments in Southern Europe and Latin America, c.1920-40. Hist Human Sci. 2023 Dec;36(5):94-121. doi: 10.1177/09526951231213028. Epub 2023 Dec 6. PMID: 38077463; PMCID: PMC10700059.
AbstractDisplacing the physiological model that had held sway in 19th-century medical thinking, early 20th-century medical scientists working on hormones promoted a new understanding of the body, psychological reactions, and the sexual instinct, arguing that each were fundamentally malleable. Hormon
Beccalossi C. Italian sexology, Nicola Pende’s biotypology and hormone treatments in the 1920s. Hist Med Sante. 2017 Winter;12:73-97. doi: 10.4000/hms.1173. Epub 2018 May 28. PMID: 31501760; PMCID: PMC6733708.
AbstractThis article analyses a selection of Nicola Pendeās studies from the 1920s on āendocrinological abnormalitiesā associated with impotence, a lack of virility in men, a lack of femininity in women, and homosexuality. By analysing endocrinological sexual theories and treatments, it aims t
BECCALOSSI C. Optimizing and normalizing the population through hormone therapies in Italian science, c.1926ā1950.Ā The British Journal for the History of Science. 2020;53(1):67-88. doi:10.1017/S0007087419000906
Abstract This essay explores how hormone treatments were used to optimize and normalize individuals under Italian Fascism. It does so by taking the activities of the Biotypological Orthogenetic Institute ā an Italian eugenics and endocrinological centre founded by Nicola Pende in 1926 ā as the p
Buggy Love Potion: The Science of Insect Sex Hormones
Listen up, you sexy six-legged sirens and alluring arthropods! šš Get ready to have your mind blown and your exoskeleton rocked. Insect sex hormones: They’re real, they’re spectacular, and they’re changing the game of love in the miniature world! From ecdysone’s double
Sex-determining region Y proteinĀ (SRY), orĀ testis-determining factorĀ (TDF)
Sex-determining region Y protein (SRY), or testis-determining factor (TDF), is a DNA-binding protein (also known as gene-regulatory protein/transcription factor) encoded by the SRY gene that is responsible for the initiation of male sex determination