Category: Endogenous steroids
-
🧬 What Is Beta-Glucuronidase?
Beta-glucuronidase (βG) is a lysosomal enzyme that catalyzes the hydrolysis of glucuronides—meaning it breaks apart compounds that have been conjugated with glucuronic acid during Phase II liver detoxification. It is the undoer of the covenant—the enzyme that breaks the seal. Sources of Beta-Glucuronidase Source Type Examples Notes Human cells Colonocytes, liver cells Endogenous production for…
-
Reactive arthritis aka Reiter’s syndrome
Reportedly triggered by everything from food poisoning to bug bites to STDs to hormones (estrogen, relaxin) Mnemonic: Can't See, Can't Pee, Can't Climb a Tree
-
The Yolk’s On Us: Unraveling the Secrets of Vitellogenesis
Hold onto your ovaries, folks! We’re about to dive into the wild world of Vitellogenesis – the cellular rave where eggs get their groove on! Picture this: You’re a lonely liver cell, minding your own business, when suddenly – BAM! – you’re hit with a tsunami of estradiol. It’s like Mother Nature’s Red Bull, and…
-
Riboflavin and its breakdown products interact with DNA, making this system attractive in the photodisinfection of blood and blood products
The application of photosensitisers to tropical pathogens in the blood supply Mark Wainwright PhD, Mauricio S. Baptista, in Photodiagnosis and Photodynamic Therapy, 2011 Riboflavin As vitamin B2, riboflavin (Fig. 5) is an essential nutrient in humans. The Mirasol system (Navigant Biotechnologies Inc., CO, USA) utilises riboflavin as a photosensitiser in conjunction with long-wave ultraviolet light [37]. Plainly given its essential nature, there are fewer potential toxicity problems…
-
Mycoestrogens are xenoestrogens produced by fungi. They are sometimes referred to as mycotoxins.
Among important mycoestrogens are zearalenone, zearalenol and zearalanol. Although all of these can be produced by various Fusarium species, zearalenol and zearalanol may also be produced endogenously in ruminants that have ingested zearalenone. Alpha-zearalanol is also produced semisynthetically, for veterinary use; such use is prohibited in the European Union. Sources Mycoestrogens are produced by various strains of fungi, many of which fall…
-
Neuromedin U
Neuromedin U (or NmU) is a neuropeptide found in the brain of humans and other mammals, which has a number of diverse functions including contraction of smooth muscle, regulation of blood pressure, pain perception, appetite, bone growth, and hormone release. It was first isolated from the spinal cord in 1985, and named after its ability to cause smooth muscle contraction in the uterus. Structure Neuromedin…
-
Adrenarche and Adrenopause
Adrenarche is an early stage in sexual maturation that happens in some higher primates and in humans, typically peaks at around 20 years of age, and is involved in the development of pubic hair, body odor, skin oiliness, axillary hair, sexual attraction/sexual desire/increased libido and mild acne. During adrenarche the adrenal glands secrete increased levels of weak adrenal androgens, including dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-S), and androstenedione (A4), but without increased cortisol levels. Adrenarche is the result of the development of a…
-
Calcitriol
Medical use Adverse effects Mechanism of action Calcitriol increases blood calcium levels ([Ca2+]) by: Biosynthesis and its regulation Interactive pathway map Metabolism History Names External links Hormones Vitamins (A11) Drugs used for psoriasis (D05) Vitamin D receptor modulators Portal: Medicine Categories: From Wikipedia where this page was last updated August 4, 2022
-
24S-Hydroxycholesterol
24S-Hydroxycholesterol (24S-HC), also known as cholest-5-ene-3,24-diol or cerebrosterol, is an endogenousoxysterol produced by neurons in the brain to maintain cholesterolhomeostasis. [1] It was discovered in 1953 by Alberto Ercoli, S. Di Frisco, and Pietro de Ruggieri, who first isolated the molecule in the horse brain [2] and then demonstrated its presence in the human brain. [3] 24S-HC is produced by a hydroxy group substitution at carbon number 24 in cholesterol, catalyzed by…
-
21-Hydroxypregnenolon
21-Hydroxypregnenolone, also known as prebediolone, as well as 3β,21-dihydroxypregn-5-en-20-one, is a naturally occurring and endogenous pregnane steroid, and an intermediate in the biosynthesis of 11-deoxycorticosterone (21-hydroxyprogesterone), corticosterone (11β,21-dihydroxyprogesterone), and other corticosteroids. [Wishart, David S.; Guo, An Chi; Oler, Eponine; Wang, Fel; Anjum, Afia; Peters, Harrison; Dizon, Raynard; Sayeeda, Zinat; Tian, Siyang; Lee, Brian L.; Berjanskii, Mark; Mah, Robert; Yamamoto, Mai; Jovel Castillo, Juan; Torres Calzada, Claudia; Hiebert Giesbrecht, Mickel; Lui, Vicki…
-
17α-Hydroxypregnenolone
17α-Hydroxypregnenolone is a pregnane (C21) steroid that is obtained by hydroxylation of pregnenolone at the C17α position. This step is performed by the mitochondrialcytochrome P450 enzyme 17α-hydroxylase (CYP17A1) that is present in the adrenal and gonads. Peak levels are reached in humans at the end of puberty and then decline. Hill M, Lukác D, Lapcík O, Sulcová J, Hampl R, Pouzar V, Stárka L (April 1999). “Age relationships and sex differences…
-
Dihydrotestosterone glucuronide
No page at wikipedia – found in a chart
-
Dihydrotestosterone sulfate
No page at wikipedia – found in a chart
