Category: Hormones
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Neuromedin U
Neuromedin U (or NmU) is a neuropeptide found in the brain of humans and other mammals, which has a number of diverse functions including contraction of smooth muscle, regulation of blood pressure, pain perception, appetite, bone growth, and hormone release. It was first isolated from the spinal cord in 1985, and named after its ability to cause smooth muscle contraction in the uterus. Structure Neuromedin…
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Neuromedin S
Neuromedin S is a 36-amino acid neuropeptide found in the brain of humans and other mammals. It is produced in the suprachiasmatic nucleus of the hypothalamus and is related to neuromedin U. It is thought to be involved in regulation of circadian rhythm and also has appetite suppressant effects, as well as regulating the release of several other peptide hormones including vasopressin, luteinizing hormone, and oxytocin. See also References Peptides: neuropeptides Categories:
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Neuromedin B
Neuromedin B (NMB) is a bombesin-related peptide in mammals. It was originally purified from pig spinal cord, and later shown to be present in human central nervous system and gastrointestinal tract. Sequence The sequence of the C-terminal decapeptide is highly conserved across mammalian species: GNLWATGHFM-(NH2); this decapeptide is sometimes noted as neuromedin B, but it is more accurately described as neuromedin B…
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Bombesin (and a wee bit of ranatensin)
Bombesin is a 14-amino acid peptide originally isolated from the skin of the European fire-bellied toad (Bombina bombina) by Vittorio Erspamer et al. and named after its source. It has two known homologs in mammals called neuromedin B and gastrin-releasing peptide. It stimulates gastrin release from G cells. It activates three different G-protein-coupled receptors known as BBR1, -2, and -3. It also activates these receptors in the brain. Together with cholecystokinin, it is the second major source of negative feedback signals that stop…
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The lactating birds and the bees (gastrin, pepsin, etc)
Crop milk is a secretion from the lining of the crop of parent birds that is regurgitated to young birds. It is found among all pigeons and doves where it is referred to as pigeon milk. An analog to crop milk is also secreted from the esophagus of flamingos and the male emperor penguin. Description Crop milk bears little physical resemblance to mammalian milk. Crop milk is a…
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Columbidae anatomy and physiology notes
Overall, the anatomy of Columbidae is characterized by short legs, short bills with a fleshy cere, and small heads on large, compact bodies. Like some other birds, the Columbidae have no gall bladders. Some medieval naturalists concluded they have no bile (gall), which in the medieval theory of the four humours explained the allegedly sweet disposition of doves. In fact, however, they do have bile (as Aristotle had…
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Temporins and Musth or must
Temporins are a family of peptides isolated originally from the skin secretion of the European red frog, Rana temporaria. Peptides belonging to the temporin family have been isolated also from closely related North American frogs, such as Rana sphenocephala. In elephants, temporin is secreted by temporal glands during the period of musth. It contains proteins, lipids (notably cholesterol), phenols, cresols and sesquiterpenes (notably farnesol and its derivatives). This is not related to temporins that are antimicrobial peptides. In old Sanskrit…
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The violet gland
The violet gland or supracaudal gland is a gland located on the upper surface of the tail of certain mammals, including European badgers and canids such as foxes, wolves, and the domestic dog,[verification needed] as well as the domestic cat. Like many other mammalian secretion glands, the violet gland consists of modified sweat glands and sebaceous glands. It is used for intra-species signalling, scent marking, and contributes to the strong odor of foxes in particular. Although it secretes a mixture…
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Adrenarche and Adrenopause
Adrenarche is an early stage in sexual maturation that happens in some higher primates and in humans, typically peaks at around 20 years of age, and is involved in the development of pubic hair, body odor, skin oiliness, axillary hair, sexual attraction/sexual desire/increased libido and mild acne. During adrenarche the adrenal glands secrete increased levels of weak adrenal androgens, including dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-S), and androstenedione (A4), but without increased cortisol levels. Adrenarche is the result of the development of a…
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Carbazochrome is an antihemorrhagic or hemostatic agent
Carbazochrome is an antihemorrhagic, or hemostatic, agent that will cease blood flow by causing the aggregation and adhesion of platelets in the blood to form a platelet plug, ceasing blood flow from an open wound. It is hoped that this drug can be used in the future for preventing excessive blood flow during surgical operations and the treatment…
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Adrenochrome
Adrenochrome is a chemical compound produced by the oxidation of adrenaline (epinephrine). It was the subject of limited research from the 1950s through to the 1970s as a potential cause of schizophrenia. While it has no current medical application, the related derivative compound, carbazochrome, is a hemostatic medication. Despite this compound’s name, it is unrelated to the element chromium; instead, the ‑chrome suffix indicates a relationship to color, as pure adrenochrome…
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Medical uses of adrenaline
Main article: Epinephrine (medication) As a medication, it is used to treat several conditions, including allergic reaction anaphylaxis, cardiac arrest, and superficial bleeding. Inhaled adrenaline may be used to improve the symptoms of croup. It may also be used for asthma when other treatments are not effective. It is given intravenously, by injection into a muscle, by inhalation, or by injection just under the skin. Common…
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Adrenaline has been isolated from the plant Scoparia dulcis found in Northern Vietnam
Scoparia dulcis is a species of flowering plant in the plantain family. Plantaginaceae, the plantain family, is a large, diverse family of flowering plants in the order Lamiales that includes common flowers such as snapdragon and foxglove. It is unrelated to the banana-like fruit also called “plantain.” Common names for Scoparia dulcis include licorice weed, goatweed, scoparia-weed and sweet-broom in English, tapeiçava, tapixaba, and vassourinha in Portuguese, escobillo in Spanish, and tipychä kuratu in Guarani. It is native to the Neotropics but it can be found throughout the…
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Adrenaline, aka epinephrine, is a hormone and medication involved in regulating visceral functions (e.g., respiration)
Adrenaline, also known as epinephrine, is a hormone and medication which is involved in regulating visceral functions (e.g., respiration). It appears as a white microcrystalline granule. Adrenaline is normally produced by the adrenal glands and by a small number of neurons in the medulla oblongata. It plays an essential role in the fight-or-flight response by increasing blood flow to muscles, heart output by acting on the SA node,pupil dilation response, and blood…
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An example of a process involving p300 and CBP is G protein signaling
Function in G protein signaling Some G proteins stimulate adenylate cyclase that results in elevation of cAMP. cAMP stimulates PKA, which consists of four subunits, two regulatory and two catalytic. Binding of cAMP to the regulatory subunits causes release of the catalytic subunits. These subunits can then enter the nucleus to interact with transcriptional factors, thus affecting gene transcription.…
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Bile acid receptor (BAR) aka farnesoid X receptor (FXR) or NR1H4
The bile acid receptor (BAR), also known as farnesoid X receptor (FXR) or NR1H4 (nuclear receptor subfamily 1, group H, member 4), is a nuclear receptor that is encoded by the NR1H4 gene in humans. Function FXR is expressed at high levels in the liver and intestine. Chenodeoxycholic acid and other bile acids are natural ligands for FXR. Similar to other nuclear receptors, when activated, FXR translocates to the cell nucleus, forms…
