Neurological
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ADAM22: The Brain’s Gatekeeper
ADAM22 is a unique member of the ADAM family, primarily expressed in the brain. Unlike many of its relatives, ADAM22 is a non-catalytic metalloprotease-like protein, meaning it lacks proteolytic activity4.… Read more.
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Patent for protecting and treating organophosphate-induced neuronal injury with tobacco-derived cembranoids and analogues
Ford, Byron, Ferchmin Peter, Eterovic, Vesna, Methods and compositions for protecting and treating neuroinjury (Patent), United States Grant US-8530525-B2 Assignee: Central University of the Caribbean, Morehouse School of Medicine, Status: Active,… Read more.
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CBP has intrinsic聽acetyltransferase聽functions
Cyclic adenosine monophosphate聽Response聽Element聽Binding protein聽Binding聽Protein (CREB-binding protein), also known as聽CREBBP聽or聽CBP聽or聽KAT3A, is a聽coactivator聽encoded by the聽CREBBP聽gene聽in humans, located on chromosome 16p13.3. CBP has intrinsic聽acetyltransferase聽functions; it is able to add acetyl groups to both… Read more.
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In mouse models of Alzheimer’s Disease, it has been shown that there is a decrease in neuronal histone acetylation, a critical function of CBP
Alzheimer’s Disease (AD) is a progressive neurodegenerative disease whose pathology is diagnosed based on the presence of neuritic amyloid beta (A尾) plaques and neurofibrillary tau (蟿) tangles.聽Because the exact causes… Read more.
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Diminished CBP activity and decreased neuronal histone acetylation is associated with Huntington’s Disease
Huntington’s Disease (HD) is a fatal, progressing neurodegenerative disorder that is the result of a genetic mutation in the聽Huntingtin聽gene causing synthesis of a mutated huntingtin (Htt) protein.聽Symptoms most frequently associated… Read more.
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Decreased concentrations of CBP and lower amounts of H3 and H4 acetylation associated with fetal alcohol spectrum disorders
Fetal alcohol spectrum disorders聽(FASD) is a classification of diseases that all result from alcohol exposure during pregnancy.聽Symptoms of these disorders include poor cerebellar-dependent learning, motor coordination and impaired balance.聽In rats… Read more.
