Autacoids Unleashed: The Self-Made, Self-Destructive Hormones You Didn’t Know You Needed
What Are Autacoids? Autacoids (or autocoids) are the body’s DIY hormones—locally produced, short-lived biochemical messengers that scream, “I got this!” before promptly fading into oblivion. The term comes from the Greek autos (self) and acos (relief or drug), which is ir
Snake Venom: A Timeless Fascination
The history of humans studying snake venom is as fascinating as the venom itself, stretching back thousands of years. Let’s take a journey through time to explore how venom has captivated and terrified humanity, and how our understanding has evolved. Ancient Beginnings: Venom as Weapon and Medicin
Snake venom can have significant effects on fat distribution and adipose tissue
Stimulation of adipose tissue cells: Bothrops moojeni snake venom (Bmv) has been shown to stimulate preadipocytes, which are precursor cells to fat cells. This stimulation leads to the release of inflammatory mediators such as PGE2, IL-6, and KC/IL-8. Increased lipid accumulation: Bmv has been obser
Snake Venom: The Hormone Hijacker 🐍
Imagine a villainous mastermind that can infiltrate your body’s hormonal headquarters, manipulating the delicate balance of estrogen and other hormones. Welcome to the world of snake venom, where the stakes are high and the effects are unpredictable. Estrogen’s Uninvited Guest: When Snak
envenomation during pregnancy is associated with increased risks including miscarriage
Several studies and case reports indicate that snake envenomation during pregnancy is associated with an increased risk of adverse outcomes, including miscarriage: Spontaneous abortions: Multiple studies report high rates of spontaneous abortions following venomous snake bites in pregnant women. One
intriguing similarities between blood clotting issues associated with birth control and those caused by venomous snake bites
Estrogen effects: Birth control pills containing estrogen can increase blood clotting factors, potentially leading to an increased risk of blood clots. Similarly, some snake venoms contain components that can activate the blood clotting system. Dual mechanisms: Both birth control and certain sn
Contraceptive effects of thermolysin?
We can draw some interesting connections based on the available information: Metalloproteinases: Thermolysin is a metalloproteinase, similar to the ADAM proteins and snake venom metalloproteinases (SVMPs) in other notes. These proteins share structural similarities and may have related functions. Po
Snake Venom as birth Control?
The research suggests some intriguing connections between snake venom components and reproductive processes: Reproductive dysfunction: Studies on Echis ocellatus venom show it can induce reproductive dysfunction in male rats, affecting sperm parameters, hormone levels, and reproductive organ tissues
recent breakthrough using ai to design proteins that can neutralize lethal snake venom toxins
This development, published in Nature on January 15, 2025, represents a significant advancement in snakebite treatment. Key highlights of this breakthrough include: –AI-designed proteins protected mice against lethal doses of snake toxins, achieving an 80-100% survival rate. –The new app
ADAM36: The Reproductive Enigma
ADAM36 is the protein that’s playing a mysterious role in the world of reproduction! ADAM36 is like that enigmatic character in a novel who appears briefly but leaves a lasting impression. This protein is primarily expressed in the male reproductive system, particularly in the testis and epidi
ADAM35: The Phantom Protein
ADAM35 is the protein that’s playing hide-and-seek with scientists! ADAM35 is like that elusive celebrity who everyone’s heard of but no one’s actually seen. This protein is shrouded in mystery, with researchers still debating its very existence in humans. Picture ADAM35 as the Big
ADAM27: The Redundant Reproductive Regulator
ADAM27 is the protein that’s playing a subtle yet intriguing role in the world of reproduction! ADAM27 is like that understudy who’s always ready to step in but rarely gets called onto the stage. This protein is exclusively expressed in the testis, suggesting it’s got some reproduc
ADAM26: The Sperm’s Surface Specialist
ADAM26 is the protein that’s making waves on the surface of sperm! ADAM26 is like that friend who’s always on the front lines, ensuring everything runs smoothly. This protein is specifically expressed on the surface of sperm, where it plays a crucial role in sperm-egg interactions. Pictu
ADAM25: The Testicular Troublemaker
ADAM25 is the protein that’s making waves in the world of male reproduction! ADAM25, also known as testase 2, is like that friend who only shows up for guy’s night out. This protein is exclusively expressed in the testes, suggesting it’s got some serious business to attend to in th
ADAM28: The Lymphocyte’s Little Helper
ADAM28 is the protein that’s bringing a whole new meaning to “immune system support”! ADAM28 is like that friend who’s always hanging out with the cool kids – in this case, the lymphocytes. This protein is exclusively expressed by lymphocytes, making it the VIP member o
ADAM24: The Sperm’s Secret Weapon
ADAM24 is the protein that’s giving sperm their cutting edge! ADAM24, also known as Testase 1, is the James Bond of the sperm world. This plasma membrane-anchored protease is found exclusively on mature sperm, ready to spring into action when duty calls1. It’s believed to play a crucial