The history of humans studying snake venom is as fascinating as the venom itself, stretching back thousands of years. Let’s take a journey through time to explore how venom has captivated and terrified humanity, and how our understanding has evolved. Ancient Beginnings: Venom as Weapon and Medicine Humans have beenContinue Reading

Imagine a villainous mastermind that can infiltrate your body’s hormonal headquarters, manipulating the delicate balance of estrogen and other hormones. Welcome to the world of snake venom, where the stakes are high and the effects are unpredictable. Estrogen’s Uninvited Guest: When Snake Venom Crashes the Hormone Hoedown Prepare for theContinue Reading

Several studies and case reports indicate that snake envenomation during pregnancy is associated with an increased risk of adverse outcomes, including miscarriage: Spontaneous abortions: Multiple studies report high rates of spontaneous abortions following venomous snake bites in pregnant women. One study found that nearly 30% of envenomated pregnant mothers experiencedContinue Reading

Estrogen effects: Birth control pills containing estrogen can increase blood clotting factors, potentially leading to an increased risk of blood clots. Similarly, some snake venoms contain components that can activate the blood clotting system. Dual mechanisms: Both birth control and certain snake venoms can affect blood clotting in opposing ways: BirthContinue Reading

We can draw some interesting connections based on the available information: Metalloproteinases: Thermolysin is a metalloproteinase, similar to the ADAM proteins and snake venom metalloproteinases (SVMPs) in other notes. These proteins share structural similarities and may have related functions. Potential interference with reproduction: Given that some metalloproteinases can interfere withContinue Reading

The research suggests some intriguing connections between snake venom components and reproductive processes: Reproductive dysfunction: Studies on Echis ocellatus venom show it can induce reproductive dysfunction in male rats, affecting sperm parameters, hormone levels, and reproductive organ tissues. ADAM protein family: Snake venom metalloproteinases (SVMPs) are closely related to ADAMContinue Reading

This development, published in Nature on January 15, 2025, represents a significant advancement in snakebite treatment. Key highlights of this breakthrough include: –AI-designed proteins protected mice against lethal doses of snake toxins, achieving an 80-100% survival rate. –The new approach targets three-finger toxins (3FTxs), which are often resistant to traditionalContinue Reading

ADAM36 is the protein that’s playing a mysterious role in the world of reproduction! ADAM36 is like that enigmatic character in a novel who appears briefly but leaves a lasting impression. This protein is primarily expressed in the male reproductive system, particularly in the testis and epididymis. Picture ADAM36 asContinue Reading

ADAM35 is the protein that’s playing hide-and-seek with scientists! ADAM35 is like that elusive celebrity who everyone’s heard of but no one’s actually seen. This protein is shrouded in mystery, with researchers still debating its very existence in humans. Picture ADAM35 as the Bigfoot of the protein world. While itContinue Reading

ADAM26 is the protein that’s making waves on the surface of sperm! ADAM26 is like that friend who’s always on the front lines, ensuring everything runs smoothly. This protein is specifically expressed on the surface of sperm, where it plays a crucial role in sperm-egg interactions. Picture ADAM26 as theContinue Reading