Category: Salivary Glands
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Intrinsic factor (IF) and haptocorrin (transcobalamin I) are necessary for the absorption of vitamin B12
Intrinsic factor (IF), cobalamin binding intrinsic factor, also known as gastric intrinsic factor (GIF), is a glycoprotein produced by the parietal cells (in humans) or chief cells (in rodents) of the stomach. It is necessary for the absorption of vitamin B12 later on in the distal ileum of the small intestine. In humans, the gastric intrinsic factor protein is encoded by the CBLIFgene. Haptocorrin (transcobalamin I) is another glycoprotein secreted by the salivary glands which binds…
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