Category: ALL THEM BONES
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Thermolysin – The Tiny Terminator of Plasma Proteins!
Both thermolysin and snake venom metalloproteinases (SVMPs) share a similar mechanism of action, utilizing zinc ions to hydrolyze peptide bonds in proteins
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Pituri, aka mingkulpa, is a mixture of leaves and wood ash traditionally chewed as a stimulant (or, after extended use, a depressant) by Aboriginal Australians widely across the continent.
Leaves are gathered from any of several species of native tobacco (Nicotiana) or from at least one distinct population of the species Duboisia hopwoodii. Various species of Acacia, Grevillea and Eucalyptus are burned to produce the ash. The term “pituri” may also refer to the plants from which the leaves are gathered or from which the ash is made. Some authors use…
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The term “hormesis” derives from Greek hórmēsis for “rapid motion, eagerness”, itself from ancient Greek hormáein to excite. The same Greek root provides the word hormone.
Hormesis is a two-phased dose-response relationship to an environmental agent whereby low-dose amounts have a beneficial effect and high-dose amounts are either inhibitory to function or toxic. Within the hormetic zone, the biological response to low-dose amounts of some stressors is generally favorable. An example is the breathing of oxygen, which is required in low amounts (in air) via respiration in living animals, but can…
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Daniel Carleton Gajdusek (1923 – 2008) was an American physician and medical researcher who was the co-recipient (with Baruch S. Blumberg) of the Nobel Prize in Physiology or Medicine in 1976 for work on the transmissibility of kuru, implying the existence of an infectious agent, which he named an ‘unconventional virus’.
His papers are held at the National Library of Medicine in Bethesda, Maryland and at the American Philosophical Society in Philadelphia, Pennsylvania. Early life and education Gajdusek’s father, Karol Gajdusek, was a Slovak butcher from Smrdáky, Kingdom of Hungary, now Slovakia. His mother Ottilia Dobróczki, and maternal grandparents, ethnic Hungarians of the Calvinist faith, emigrated from Debrecen, Hungary. Gajdusek was born in Yonkers, New York, and graduated…
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Adamalysin II, the protein world’s very own Eastern diamondback rattlesnake superstar
Adamalysin II, alias proteinase II, a 24 kDa zinc-endopeptidase isolated from the snake venom of the Eastern diamondback rattlesnake Crotalus adamanteus, is a prototype, of the proteolytic domain of snake venom metalloproteinases and of domains found in mammalian reproductive tract proteins.
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Marx SO, Reiken S, Hisamatsu Y, Gaburjakova M, Gaburjakova J, Yang YM, Rosemblit N, Marks AR. Phosphorylation-dependent regulation of ryanodine receptors: a novel role for leucine/isoleucine zippers. J Cell Biol. 2001 May 14;153(4):699-708. doi: 10.1083/jcb.153.4.699. PMID: 11352932; PMCID: PMC2192391.
Abstract Ryanodine receptors (RyRs), intracellular calcium release channels required for cardiac and skeletal muscle contraction, are macromolecular complexes that include kinases and phosphatases. Phosphorylation/dephosphorylation plays a key role in regulating the function of many ion channels, including RyRs. However, the mechanism by which kinases and phosphatases are targeted to ion channels is not well understood.…
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Oxytocin: The Molecular Maestro of Love and Labor
Buckle up, hormone enthusiasts! We’re about to take a wild ride into the world of oxytocin, the “love hormone” that’s been playing Cupid in our bodies since the dawn of mammalian evolution. This tiny peptide packs a punch that would make even Hercules jealous! Picture this: a molecule barely 1007 Da in size, strutting around…
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Valine
Valine (symbol Val or V) is an α-amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated −NH3+ form under biological conditions), an α-carboxylic acid group (which is in the deprotonated −COO− form under biological conditions), and a side chain isopropyl group, making it a non-polar aliphatic amino acid. Valine is essential in humans, meaning the body cannot synthesize it; it…
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Insall R. Dispatch. Dictyostelium chemotaxis: fascism through the back door? Curr Biol. 2003 Apr 29;13(9):R353-4. doi: 10.1016/s0960-9822(03)00274-4. PMID: 12725750.
Abstract Aggregating Dictyostelium cells secrete cyclic AMP to attract their neighbours by chemotaxis. It has now been shown that adenylyl cyclase is enriched in the rear of cells, and this localisation is required for normal aggregation. Dictyostelium discoideum cells undergo a major lifestyle change when they get hungry. They grow as unicellular amoebas, but when food starts to…
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Eraso Y. Biotypology, endocrinology, and sterilization: the practice of eugenics in the treatment of Argentinian women during the 1930s. Bull Hist Med. 2007 Winter;81(4):793-822. doi: 10.1353/bhm.2007.0130. PMID: 18084107; PMCID: PMC2629848.
SUMMARYThis article looks at medical approaches to women’s fertility in Argentina in the 1930s and explores the ways in which eugenics encouraged the reproduction of the fit and attempted to avoid the reproduction of the unfit. The analysis concentrates on three main aspects: biotypology (the scientific classification of bodies), endocrine therapy, and sterilization. The article…
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the hormone hustle
We’re about to embark on a time-traveling, mind-bending journey through the evolution of normalization, biopolitics, and the wild world of hormones. From Foucault’s philosophical bombshells to Nicola Pende’s hormone-fueled science experiments, this is a story that will leave you questioning everything you thought you knew about “normal.” Act I: The Birth of Biopower (18th Century) Picture…
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Beccalossi C. Sexology, sexual development, and hormone treatments in Southern Europe and Latin America, c.1920-40. Hist Human Sci. 2023 Dec;36(5):94-121. doi: 10.1177/09526951231213028. Epub 2023 Dec 6. PMID: 38077463; PMCID: PMC10700059.
AbstractDisplacing the physiological model that had held sway in 19th-century medical thinking, early 20th-century medical scientists working on hormones promoted a new understanding of the body, psychological reactions, and the sexual instinct, arguing that each were fundamentally malleable. Hormones came to be understood as the chemical messengers that regulated an individual’s growth and sexual development,…
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Beccalossi C. Italian sexology, Nicola Pende’s biotypology and hormone treatments in the 1920s. Hist Med Sante. 2017 Winter;12:73-97. doi: 10.4000/hms.1173. Epub 2018 May 28. PMID: 31501760; PMCID: PMC6733708.
AbstractThis article analyses a selection of Nicola Pende’s studies from the 1920s on ‘endocrinological abnormalities’ associated with impotence, a lack of virility in men, a lack of femininity in women, and homosexuality. By analysing endocrinological sexual theories and treatments, it aims to illustrate the ways in which hormone research pioneered an innovative approach to the…
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BECCALOSSI C. Optimizing and normalizing the population through hormone therapies in Italian science, c.1926–1950. The British Journal for the History of Science. 2020;53(1):67-88. doi:10.1017/S0007087419000906
Abstract This essay explores how hormone treatments were used to optimize and normalize individuals under Italian Fascism. It does so by taking the activities of the Biotypological Orthogenetic Institute − an Italian eugenics and endocrinological centre founded by Nicola Pende in 1926 − as the prime example of a version of eugenics, biotypology, which was…
