Omenn syndrome symptoms are very similar to those of graft-versus-host disease (GVHD) due to abnormal T cells that have a specific affinity for self antigens found in the thymus and in the periphery and limited levels of recombination with mutant RAG genes
Omenn syndrome is an autosomal recessive severe combined immunodeficiency. It is associated with hypomorphic missense mutations in immunologically relevant genes of T-cells
Adenosine deaminase deficiency (ADA deficiency) was discovered in 1972 and recognized as the first immunodeficiency disorder
Adenosine deaminase deficiency (ADA deficiency) is a metabolic disorder that causes immunodeficiency. It is caused by mutations in the ADA gene. It accounts for about 10–15%