Category: Complement
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Adenosine deaminase deficiency (ADA deficiency) was discovered in 1972 and recognized as the first immunodeficiency disorder
Adenosine deaminase deficiency (ADA deficiency) is a metabolic disorder that causes immunodeficiency. It is caused by mutations in the ADA gene. It accounts for about 10–15% of all cases of autosomal recessive forms of severe combined immunodeficiency (SCID) among non-inbred populations. ADA deficiency can present in infancy, childhood, adolescence, or adulthood. Age of onset and severity is related to some 29 known genotypes associated with the disorder. It occurs…
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Fischer-Fantuzzi L, Vesco C. Deletion of 43 amino acids in the NH2-terminal half of the large tumor antigen of simian virus 40 results in a non-karyophilic protein capable of transforming established cells. Proc Natl Acad Sci U S A. 1985
Abstract We have characterized a simian virus 40 (SV40) mutant, derived from the viral DNA insertion present in simian cell transformants, which carries a deletion affecting the NH2-terminal region of the SV40 large tumor antigen. This mutant protein is 6% smaller than normal, has lost the typical nuclear localization of the SV40 large tumor antigen,…
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Nucleus accumbens aka accumbens nucleus
The nucleus accumbens (NAc or NAcc; also known as the accumbens nucleus, or formerly as the nucleus accumbens septi, Latin for “nucleus adjacent to the septum“) is a region in the basal forebrain rostral to the preoptic area of the hypothalamus. The nucleus accumbens and the olfactory tubercle collectively form the ventral striatum. The ventral striatum and dorsal striatum collectively form the striatum, which is the main component of the basal ganglia. The dopaminergic neurons of the mesolimbic pathway project onto the GABAergic medium…
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Sonification
Sonification is the use of non-speech audio to convey information or perceptualize data. Auditory perception has advantages in temporal, spatial, amplitude, and frequency resolution that open possibilities as an alternative or complement to visualization techniques. For example, the rate of clicking of a Geiger counter conveys the level of radiation in the immediate vicinity of the device. Though many experiments with data sonification have been explored in forums…
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A columbarium is a structure for the reverential and usually public storage of funerary urns holding cremains of the dead
A columbarium (pl. columbaria) is a structure for the reverential and usually public storage of funerary urns holding cremains of the dead. The term comes from the Latin columba (dove) and originally solely referred to compartmentalized housing for doves and pigeons, also called dovecotes. Background Roman columbaria were often built partly or completely underground. The Columbarium of Pomponius Hylas is an ancient Roman example, rich in frescoes, decorations, and…
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Dis Pater aka Rex Infernus, Roman god of the underworld, contracted from Dives Pater (“Father of Riches”)
Dīs Pater (Dītis Patris), otherwise known as Rex Infernus or Pluto, is a Roman god of the underworld. Dis was originally associated with fertile agricultural land and mineral wealth, and since those minerals came from underground, he was later equated with the chthonic deities Pluto (Hades) and Orcus. Dīs Pater’s name was commonly shortened to Dīs, and this name has since become an alternative name for the underworld or a part…
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Car of History chariot clock features a life size statue of Clio, the muse of history
A chariot clock is a type of mantel/table figural clock in the form of a chariot whose dial is set into the wheel or elsewhere, its origins date back to the second half of the 16th century southern Germany. Normally of classical mythology subject matter, it has been made in different periods and styles such as Renaissance, Louis XV, Louis XVI, Empire, Napoleon…
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Adrenaline has been isolated from the plant Scoparia dulcis found in Northern Vietnam
Scoparia dulcis is a species of flowering plant in the plantain family. Plantaginaceae, the plantain family, is a large, diverse family of flowering plants in the order Lamiales that includes common flowers such as snapdragon and foxglove. It is unrelated to the banana-like fruit also called “plantain.” Common names for Scoparia dulcis include licorice weed, goatweed, scoparia-weed and sweet-broom in English, tapeiçava, tapixaba, and vassourinha in Portuguese, escobillo in Spanish, and tipychä kuratu in Guarani. It is native to the Neotropics but it can be found throughout the…
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Proteins shown to interact specifically with CBP (list)
ActrNuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300.Karamouzis MV, Konstantinopoulos PA, Papavassiliou AG (April 2007). “Roles of CREB-binding protein (CBP)/p300 in respiratory epithelium tumorigenesis”. Cell Research. 17 (4): 324–332. doi:10.1038/cr.2007.10. PMID 17372613. S2CID 36084602.Dyson HJ, Wright PE (March 2016). “Role of Intrinsic Protein Disorder in the Function and Interactions of the Transcriptional Coactivators CREB-binding Protein (CBP)…
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Hydrangea macrophylla
Hydrangea macrophylla is a species of flowering plant in the family Hydrangeaceae, native to Japan. It is a deciduous shrub growing to 2 m (7 ft) tall by 2.5 m (8 ft) broad with large heads of pink or blue flowers in summer and autumn. Common names include bigleaf hydrangea, French hydrangea, lacecap hydrangea, mophead hydrangea, penny mac and hortensia. It is widely cultivated in many parts of the world in many climates. It is not to…
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T helper cells (Th cells), also known as CD4+ cells or CD4-positive cells
The T helper cells (Th cells), also known as CD4+ cells or CD4-positive cells, are a type of T cell that play an important role in the adaptive immune system. They aid the activity of other immune cells by releasing cytokines. They are considered essential in B cellantibody class switching, breaking cross-tolerance in dendritic cells, in the activation and growth of cytotoxic T cells, and in maximizing bactericidal activity of phagocytes such as macrophages and neutrophils. CD4+ cells…
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Surfeit human gene cluster
Surfeit is a human gene cluster that consists of a group of very tightly linked genes on chromosome 9 that do not share sequence similarity. Genes in this cluster are numbered 1 through 6: SURF1, SURF2, SURF3, SURF4, SURF5, and SURF6. Surfeit locus protein 1 (SURF1) Surfeit locus protein 1 (SURF1) is a protein that in humans is encoded by the SURF1gene. The protein encoded by SURF1 is a component of the mitochondrial…
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List of human clusters of differentiation (OR CD) MOLECULES
* = group; ** = not listed on hcdm CD1* MHC-like molecule that presents lipid molecules CD1a CD1a (Cluster of Differentiation 1a), or T-cell surface glycoprotein CD1a, is a human protein encoded by the CD1A gene. An antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. CD1b T-cell surface glycoprotein CD1b. Expressed on cortical thymocytes, certain T-cell leukemias…
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Green fluorescent protein (GFP)
The green fluorescent protein (GFP) is a protein that exhibits bright green fluorescence when exposed to light in the blue to ultraviolet range. Prendergast FG, Mann KG (Aug 1978). “Chemical and physical properties of aequorin and the green fluorescent protein isolated from Aequorea forskålea”. Biochemistry. 17 (17): 3448–53. doi:10.1021/bi00610a004. PMID 28749. Tsien RY (1998). “The green fluorescent protein” (PDF). Annual Review of Biochemistry. 67: 509–44. doi:10.1146/annurev.biochem.67.1.509. PMID 9759496 The label GFP traditionally refers to the protein first isolated…
