Complement receptor type 2Ā (CR2)
Complement receptor type 2 (CR2), also known as complement C3d receptor, Epstein-Barr virus receptor, and CD21 (cluster of differentiation 21), is a protein that in humans is encoded by the CR2 gene. CR2 is involved in theĀ complement system. It binds toĀ iC3b
Rosetting
Erythrocyte rosettingĀ orĀ E-rosettingĀ is a phenomenon seen through aĀ microscopeĀ whereĀ red blood cellsĀ (erythrocytes)Ā are arranged around a central cell to form a cluster that looks like a flower. The red blood cells surrounding the cell form theĀ petal,Ā while the central cell forms theĀ stig
Complement receptor type 1Ā (CR1)
Complement receptor type 1Ā (CR1) also known asĀ C3b/C4b receptorĀ orĀ CD35Ā (cluster of differentiation 35) is aĀ proteinĀ that in humans is encoded by theĀ CR1Ā gene. This gene is a member of theĀ regulators of complement activationĀ (RCA) family and is located in the ‘cluster RCA’ reg
Three-finger proteins and three-finger toxins
Three-finger proteins or three-finger protein domains (3FP or TFPD) are a protein superfamily consisting of small, roughly 60-80 amino acid residue protein domains with a common tertiary structure: three beta strand loops extended from
Von Willebrand factorĀ (VWF) is a large multimericĀ glycoproteinĀ present inĀ blood plasmaĀ and produced constitutively as ultra-large VWF inĀ endotheliumĀ (in theĀ WeibelāPalade bodies),Ā megakaryocytesĀ (Ī±-granules ofĀ platelets), and subendothelialĀ connective tissue
Von Willebrand factor (VWF) is a blood glycoprotein that promotes hemostasis, specifically, platelet adhesion. It is deficient and/or defective in von Willebrand disease and is involved in many other diseases, including thrombotic thrombocytopenic pu
The NACHT domain consists of seven distinct conserved motifs, including the ATP/GTPase specific P-loop, the Mg2+-binding site (Walker A and B motifs, respectively) and five more specific motifs
The NACHT domain is an evolutionarily conserved protein domain. This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription. Its name reflects some of the proteins that contain it: NAIP (NLP family
TRALI or ARDS: A Medical Game of “Who’s Who?”
Welcome to the thrilling world of post-transfusion respiratory distress, where distinguishing TRALI from ARDS is like trying to tell apart identical twins wearing the same outfit. Strap in, folks – it’s time for a wild ride through the land of bilateral infiltrates and hypoxemia! First t
OsteopontinĀ (OPN)
OsteopontinĀ (OPN), also known asĀ bone /sialoprotein IĀ (BSP-1Ā orĀ BNSP),Ā early T-lymphocyte activationĀ (ETA-1),Ā secreted phosphoprotein 1Ā (SPP1),Ā 2arĀ andĀ Rickettsia resistanceĀ (Ric),Ā is aĀ proteinĀ that in humans is encoded by theĀ SPP1Ā gene (secreted phosphoprotein 1). The murine ortho
AgrinĀ is a largeĀ chimeric proteoglycan, a heparan sulfate and chondroitin proteoglycan,Ā whose best-characterised role is in the development of theĀ neuromuscular junctionĀ duringĀ embryogenesis
Agrin was originally found in the electric organ of Tarpedo california and in the basal lamina at the neuromuscular junction as a protein that directs the aggregation of acetylcholine receptors (AChR) and acetylcholinesterase (AChE) at synaptic
Liver sinusoidal endothelial cellsĀ (LSECs) AKA theĀ hepatic sinusoids
They form the lining of the smallest blood vessels in the liver
Juvenile hormone epoxide hydrolaseĀ (JHEH) is anĀ enzymeĀ that inactivates insectĀ juvenile hormones
Juvenile hormone epoxide hydrolaseĀ (JHEH) is anĀ enzymeĀ that inactivates insectĀ juvenile hormones. This inactivation is accomplished through hydrolysis of theĀ epoxideĀ functional group contained within these hormones intoĀ diols. JHEH is one of two enzymes involved in the termination of signalin
TheĀ conjugate (10S,11S) JH diol phosphateĀ is the product of a two-step enzymatic process: conversion ofĀ JHĀ to JH diol and then addition of aĀ phosphate groupĀ to C10
TheĀ conjugate (10S,11S) JH diol phosphateĀ is the product of a two-step enzymatic process: conversion ofĀ JHĀ to JH diol and then addition of aĀ phosphate groupĀ to C10. The enzyme responsible for theĀ phosphorylationĀ of JH diol is JH diol kinase (JHDK), which was first characterized from theĀ Mal
Ku70
Ku70 is a protein that, in humans, is encoded by the XRCC6 gene.[5][6] Function Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand break ends and is required for the non-homologous end joining (NH
Ku80
Ku80 is a protein that, in humans, is encoded by the XRCC5 gene.[5] Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pat