Paracetamol is an aniline derivative with a sketchy date of birth (and a very sketchy rebirth)
Paracetamol was first made in 1877…or possibly 1852. Some reports state that Cahn & Hepp or a French chemist called Charles Gerhardt first synthesized paracetamol in 1852. Acetanilide was the first aniline derivative serendipitously found to possess analgesic as well as antipyretic pr
The word “paracetmol”
The word “paracetmol” is a shortened form of para-acetyl-amino-phenol, and was coined, manufactured and sold by Frederick Stearns & Co in 1956.
The word “acetaminophen”
The word “acetaminophen” is a shortened form of N-acetyl aminophenol, and was coined and first marketed by McNeil Laboratories in 1955.
Paracetamol is extremely toxic to cats, which lack the necessary UGT1A6 enzyme to detoxify it
Paracetamol is extremely toxic to cats, which lack the necessary UGT1A6 enzyme to detoxify it. Initial symptoms include vomiting, salivation, and discoloration of the tongue and gums. Unlike an overdose in humans, liver damage is rarely the cause of death; instead, methemoglobin formation and th
N-acetylcysteine treatment is efficacious in dogs when administered within two hours of toxic paracetamol ingestion
Paracetamol has been reported to be as effective as aspirin in the treatment of musculoskeletal pain in dogs. The main effect of toxicity in dogs is liver damage, and GI ulceration has been reported. N-acetylcysteine treatment is efficacious in dogs when administered within two hours of paracetamol
Paracetamol is lethal to snakes
Here is a tale of pharmaceutical warfare that’ll make your scales stand on end! Welcome to Guam, where the brown tree snakes are throwing the wildest party since the Ice Age, and the locals are fighting back with… Tylenol? That’s right, folks! These slithery party crashers have bee
Benefits of paracetamol for fever are unclear
Paracetamol (acetaminophen or para-hydroxyacetanilide) is a medication used to treat fever and mild to moderate pain. At a standard dose, paracetamol only slightly decreases body temperature; it is inferior to ibuprofen in that respect, and the benefits of its use for fever are unclear.
Metoclopramide, Paracetamol/metoclopramide, Witch’s Milk, Lactating Men and Homicidal Maniacs?
Metoclopramide is a medication used for stomach and esophageal problems. It is commonly used to treat and prevent nausea and vomiting, to help with emptying of the stomach in people with delayed stomach emptying, and to help with gastr
Anti-thymocyte globulin (ATG)
Anti-thymocyte globulin (ATG) is an infusion of horse or rabbit-derived antibodies against human T cells and their precursors (thymocytes), which is used in the prevention and treatment of acute rejection in organ transplantation and therapy of aplastic anemia due to bone marrow insufficien
Prolactin receptor modulators
Prolactin Agonists An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the agonist, while an inverse agoni
What Is Nitrophenol? (besides something mentioned in âScientific Opinion on the reâevaluation of aspartame as a food additiveâ)
Nitrophenols are compounds of the formula HOC6H5âx(NO2)x. The conjugate bases are called nitrophenolates. Nitrophenols are more acidic than phenol itself. Wikipedia Mono-nitrophenols with the formula HOC6H4NO2. Three isomeric nitrophenols exist: o-Nitrophenol (2-
Another reason not to feed pigeons – your food is poison?
I can’t tell you why except they showed up on a wiki search. Climate change has a negative effect on this bird, and reproductive performance decreases with increased temperatures. It is also particularly vulnerable to oil, and adults near oiled shores display symptoms of hepatocellular injur