Marx SO, Reiken S, Hisamatsu Y, Gaburjakova M, Gaburjakova J, Yang YM, Rosemblit N, Marks AR. Phosphorylation-dependent regulation of ryanodine receptors: a novel role for leucine/isoleucine zippers. J Cell Biol. 2001 May 14;153(4):699-708. doi: 10.1083/jcb.153.4.699. PMID: 11352932; PMCID: PMC2192391.
Abstract Ryanodine receptors (RyRs), intracellular calcium release channels required for cardiac and skeletal muscle contraction, are macromolecular complexes that include kinases and phosphatases. Phosphorylation/dephosphorylation plays a key role in regulating the function of many ion channels, in
p-Phenylenediamine (PPD) is a derivative of aniline used in kevlar, hair dye and henna substitutions among other things, the derivatives of which are used in antiozonants among other horrors
p-Phenylenediamine (PPD) is an organic compound with the formula C6H4(NH2)2. This derivative of aniline is a white solid, but samples can darken due to air oxidation.It is mainly used as a component of engineering polymers and composites like kevlar. It is also an ingredient in hair dyes a
Amygdalin and Laetrile
Amygdalin (from Ancient Greek: áŒÎŒÏ γΎαλΟ amygdalÄ “almond”) is a naturally occurring chemical compound found in many plants, most notably in the seeds (kernels) of apricots, bitter almonds, apples, peaches, cherries&nbs
Piceol is a phenolic compound found in the needles and in mycorrhizal roots of Norway spruces and more
Piceol is a phenolic compound found in the needles and in mycorrhizal roots of Norway spruces (Picea abies). Picein is the glucoside of piceol. Pungenin is a also phenolic compound found in the needles of Blue Spruce (Picea pungens). It is the&n
Baccharis is a genus of perennials and shrubs in the aster family (Asteraceae)
They are commonly known as baccharises but sometimes referred to as “brooms”, because many members have small thin leaves resembling the true brooms. They are not at all related to these however, but belong to an entirely different lineage of eudicots. B. halimifolia is commonly kn
Aetokthonotoxin (AETX) aka ‘eagle toxin’ discovered in 2021
Aetokthonotoxin (AETX), colloquially ‘eagle toxin’, was discovered in 2021 as the cyanobacterial neurotoxin causing vacuolar myelinopathy (VM) in eagles in North America. Avian vacuolar myelinopathy (AVM) is a fatal neurological disease that affects various waterbirds and rapt
ÎČ-Methylamino-L-alanine, or BMAA
ÎČ-Methylamino-L-alanine, or BMAA, is a non-proteinogenic amino acid produced by cyanobacteria. BMAA is a neurotoxin and its potential role in various neurodegenerative disorders is the subject of scientific research. Structure and properties BMAA is a de
Lytico-bodig disease, Guam disease, or amyotrophic lateral sclerosis-parkinsonism-dementia (ALS-PDC) is a neurodegenerative disease or all of them
Lytico-bodig (also Lytigo-bodig) disease, Guam disease, or amyotrophic lateral sclerosis-parkinsonism-dementia (ALS-PDC) is a neurodegenerative disease of uncertain etiology endemic to the Chamorro people of the island of Guam&nbs
Cassava is used in a number of commercially available laundry products
Cassava is also used in a number of commercially available laundry products, especially as starch for shirts and other garments. Using cassava starch diluted in water and spraying it over fabrics before ironing helps stiffen collars.
Phytoecdysteroids are plant-derived ecdysteroids
Phytoecdysteroids are plant-derived ecdysteroids. Phytoecdysteroids are a class of chemicals that plants synthesize for defense against phytophagous (plant eating) insects. These compounds are mimics of hormones used by arthropods in the molting process known as ecdysis. When insects
Chrysolina beetles, including Chrysolina coerulans, have cardiac glycosides (including xylose) in their defensive glands
The defensive secretions of some chrysomelid beetles belonging to the genera Chrysolina, Chrysochloa, and Dlochrysa contain complex mixtures of cardenolides. The spectral data for some of these compounds suggest that they are monohydroxylated digitoxigenin derivatives linked to a pentose (such as xy
Hydrangea macrophyllaÂ
Hydrangea macrophylla is a species of flowering plant in the family Hydrangeaceae, native to Japan. It is a deciduous shrub growing to 2 m (7 ft) tall by 2.5 m (8 ft) broad with large heads of pink or blue flowers in summer and autumn. Common names include bigleaf hydrangea, French
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Umbelliferone, also known as 7-hydroxycoumarin, hydrangine, skimmetine, and beta-umbelliferone, is a natural product of the coumarin family. It absorbs ultraviolet light strongly at several wavelengths. There are some indications that this chemical is ant
Toxin (etymology)
toxin (n.) “organic poison,” especially one produced by bacteria in an animal body, 1886, from toxic + -in (2). toxic (adj.) 1660s, from French toxique and directly from Late Latin toxicus “poisoned,” from Latin toxicum “poison,” from Greek to
Virus (etymology)
virus (n.) late 14c., “poisonous substance” (a sense now archaic), from Latin virus “poison, sap of plants, slimy liquid, a potent juice,” from Proto-Italic *weis-o-(s-) “poison,” which is probably from a PIE root *ueis-, perhaps originally meaning R