Smokers show fewer symptoms or appear less affected by certain toxins
Some smokers show fewer symptoms or appear less affected by certain toxins — arsenic included — at doses that harm nonsmokers. This isn’t protection in the traditional sense. It’s more like biochemical compensation or adaptive masking. 🔄 Possible Mechanisms Behind the Paradox Induced Deto
HFE H63D & VO2 max
SMOKE EM IF YOU GOT EM The HFE H63D is a single-nucleotide polymorphism in the HFE gene (c.187C>G, rs1799945), which results in the substitution of a histidine for an aspartic acid at amino acid position 63 of the HFE protein (p.His63Asp). HFE participates in the regulation of iron absorption.
Transferrin binding and PH
Transferrin binding to transferrin receptors reduces its affinity for iron. Two pathways can occur once endocytosed–degradation or recycling pathways. The degradation pathway is where the dissociation of ferric ions from transferrin occurs from an early and late endosome. Iron can now be utilized
Thermolysin – The Tiny Terminator of Plasma Proteins!
Both thermolysin and snake venom metalloproteinases (SVMPs) share a similar mechanism of action, utilizing zinc ions to hydrolyze peptide bonds in proteins
Arsenic: The Element of Surprise (and Murder)
Let’s dive into the sordid history of arsenic, the “King of Poisons” and the “Poison of Kings.” Our story begins in ancient times, when alchemists were busy trying to turn lead into gold. Little did they know, they were playing with fire – or rather, arsenic. Thes
Adamalysin II, the protein world’s very own Eastern diamondback rattlesnake superstar
Adamalysin II, alias proteinase II, a 24 kDa zinc-endopeptidase isolated from the snake venom of the Eastern diamondback rattlesnake Crotalus adamanteus, is a prototype, of the proteolytic domain of snake venom metalloproteinases and of domains found in mammalian reproductive tract proteins.
DMT1 aka DCT1 and NRAMP2
Natural resistance-associated macrophage protein 2 (NRAMP 2), also known as divalent metal transporter 1 (DMT1) and divalent cation transporter 1 (DCT1), is a protein that in humans is encoded by the SLC11A2 (solute carrier family 11, member 2)
Bovine serum albumin (Fraction V)
Bovine serum albumin (BSA or “Fraction V”) is a serum albumin protein derived from cows. It is often used as a protein concentration standard in lab experiments. The nickname “Fraction V” refers to albumin being the fifth fraction of the original Edwin Cohn purification
Ovotransferrin aka conalbumin
Ovotransferrin (conalbumin) is a glycoprotein of egg white albumen. Egg white albumen is composed of multiple proteins, of which ovotransferrin is the most heat reliable. It has a molecular weight of 76,000 daltons and contains about 700 amino acids. Ovotransferrin makes up approximately 13
Laterite
Laterite is a soil type rich in iron and aluminium and is commonly considered to have formed in hot and wet tropical areas. Nearly all laterites are of rusty-red coloration, because of high iron oxide content. They develop by intensive and prolonged weathering of the underlying parent rock
Saprolite
Saprolite is a chemically weathered rock. Saprolites form in the lower zones of soil profiles and represent deep weathering of the bedrock surface. In most outcrops, its color comes from ferric compounds. Deeply weathered profiles are widespread on t
Flame Test
A flame test is relatively quick test for the presence of some elements in a sample. The technique is archaic and of questionable reliability, but once was a component of qualitative inorganic analysis. The phenomenon is related to pyrotechnics and atomic emission spectroscopy. The color of t
Silicene is a two-dimensional allotrope of silicon, with a hexagonal honeycomb structure similar to that of graphene
Contrary to graphene, silicene is not flat, but has a periodically buckled topology; the coupling between layers in silicene is much stronger than in multilayered graphene; and the oxidized form of silicene, 2D silica, has a very different chemical structure from graphene oxide. History Al
Leavell, B S. “Thomas Jefferson and smallpox vaccination.” Transactions of the American Clinical and Climatological Association vol. 88 (1977): 119-27 and a few notes
Little Turtle, mentioned in the main article, suffered gout and rheumatism before he died in 1812 Wikipedia says Little Turtle, who also met Washington and Adams, made two trips to Washington, D.C., in 1801–02 and 1809–09 to meet with President Jefferson. Little Turtle died on July 14, 1812
Reactive arthritis aka Reiter’s syndrome
Reportedly triggered by everything from food poisoning to bug bites to STDs to hormones (estrogen, relaxin) Mnemonic: Can't See, Can't Pee, Can't Climb a Tree