Lumican aka LUM

Lumican, also known as LUM, is an extracellular matrix protein that, in humans, is encoded by the LUM gene on chromosome 12. Structure Lumican is a proteoglycan Class II member of the small leucine-rich proteoglycan (SLRP) family that includes decorin, biglycan, fibromodulin, keratocan, epiphycan, and osteoglycin.…

Osteopontin (OPN)

Osteopontin (OPN), also known as bone /sialoprotein I (BSP-1 or BNSP), early T-lymphocyte activation (ETA-1), secreted phosphoprotein 1 (SPP1), 2ar and Rickettsia resistance (Ric), is a protein that in humans is encoded by the SPP1 gene (secreted phosphoprotein 1). The murine ortholog is Spp1. Osteopontin is a SIBLING (glycoprotein) that was…

Phosphopyruvate hydratase, aka enolase, is a metalloenzyme that catalyses the conversion of 2-phosphoglycerate (2-PG) to phosphoenolpyruvate (PEP), the ninth and penultimate step of glycolysis

Phosphopyruvate hydratase, usually known as enolase, is a metalloenzyme (EC 4.2.1.11) that catalyses the conversion of 2-phosphoglycerate (2-PG) to phosphoenolpyruvate (PEP), the ninth and penultimate step of glycolysis. The chemical reaction is:2-phospho-D-glycerate â‡Œ phosphoenolpyruvate + H2O Phosphopyruvate hydratase belongs to the family of lyases,…

Chymase and Chymosin – Rumored To Be Synonyms (and a little renin and rennin)

Chymase Alternative name for chymosin [“chymase .” A Dictionary of Food and Nutrition. . Encyclopedia.com. 25 Aug. 2022 https://www.encyclopedia.com] Mast Cell Chymase and Tryptase and some MMPs Chymase and tryptase are packaged in secretory granules together with histamine and other mediators…

What Is Metalloproteinase?

Metalloproteinase – the name alone screams “I’m here to ruin everything” – is a feral pack of enzymes armed with metal claws (zinc, mostly, because it’s the shiniest weapon in…

What Are Plant Matrix Metalloproteinases?

Plant matrix metalloproteinases are metalloproteins and zinc enzymes found in plants. Matrix Metalloproteinase Matrix metalloproteinases (MMPs) are zinc endopeptidases, commonly called metzincins. MMP enzymes represent an ancient family of proteins with major similarities in…

What are Matrix Metalloproteinases?

The MMPs belong to a larger family of proteases known as the metzincin superfamily.[ Matrix Metalloproteinases: Its implications in cardiovascular disorders] Collectively, these enzymes are capable of degrading all kinds of extracellular matrix proteins, but also…