Category: Blood
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Xylose is the first saccharide added to the serine or threonine in the proteoglycan type O-glycosylation
Xylose is the first saccharide added to the serine or threonine in the proteoglycan type O-glycosylation, and, so, it is the first saccharide in biosynthetic pathways of most anionic polysaccharides such as heparan sulfate and chondroitin sulfate. Definitions Proteoglycans are proteins that are heavily glycosylated. The basic proteoglycan unit consists of a “core protein” with one or more covalently attached glycosaminoglycan (GAG) chain(s). The point of attachment is a serine (Ser) residue to which the glycosaminoglycan is joined through…
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Karl Landsteiner – discovered poliovirus, the rhesus factor, described as the father of transfusion medicine
Karl Landsteiner ForMemRS (14 June 1868 – 26 June 1943) was an Austrian-born American biologist, physician, and immunologist. He distinguished the main blood groups in 1900, having developed the modern system of classification of blood groups from his identification of the presence of agglutinins in the blood, and in 1937 identified, with Alexander S. Wiener, the Rhesus factor, thus enabling physicians to transfuse blood without endangering the patient’s…
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Dicoumarol (Moldy Sweet Clover) Toxicosis in a Group of Holstein Calves
Yamini B, Poppenga RH, Emmett BW, Judge LJ. Dicoumarol (Moldy Sweet Clover) Toxicosis in a Group of Holstein Calves. Journal of Veterinary Diagnostic Investigation. 1995;7(3):420-422. doi:10.1177/104063879500700328 References 1. Alstad AD, Casper HH, Johnson LJ: 1985, Vitamin K treatment of sweet clover poisoning in calves. J Am Vet Med Assoc 187:729–731. 2. Blakley BR: 1985, Moldy sweet clover (dicoumarol) poisoning in…
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Disorders of bleeding and clotting
Clotting By cause Clotting factors Antithrombin III deficiency Protein C deficiency Activated protein C resistance Protein S deficiency Factor V Leiden Prothrombin G20210A Platelets Sticky platelet syndrome Thrombocytosis Essential thrombocythemia DIC Purpura fulminans Antiphospholipid syndrome Clots Thrombophilia Thrombus Thrombosis Virchow’s triad Trousseau sign of malignancy By site Deep vein thrombosis Bancroft’s sign Homans sign Lisker’s sign Louvel’s sign Lowenberg’s…
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Antithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01)
Antiplatelet drugs Glycoprotein IIb/IIIa inhibitors Abciximab Eptifibatide Orbofiban Roxifiban Sibrafiban§Tirofiban ADP receptor/P2Y12 inhibitors Thienopyridines Clopidogrel Prasugrel Ticlopidine Nucleotide/nucleoside analogs Cangrelor Elinogrel Ticagrelor Prostaglandin analogue (PGI2) Beraprost Iloprost Prostacyclin Treprostinil COX inhibitors Acetylsalicylic acid/Aspirin# Aloxiprin Carbasalate calcium Indobufen Triflusal Thromboxane inhibitors Thromboxane synthase inhibitors Dipyridamole (+ aspirin) Picotamide Terbogrel Receptor antagonists Terbogrel Terutroban§ Phosphodiesterase inhibitors Cilostazol Dipyridamole Triflusal Other Cloricromen Ditazole Vorapaxar #WHO-EM‡Withdrawn from marketClinical…
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X-Linked Disorders
X-linked dominant inheritance X-linked dominant X-linked hypophosphatemia – Focal dermal hypoplasia – Fragile X syndrome – Aicardi syndrome – Incontinentia pigmenti – Rett syndrome – CHILD syndrome – Lujan–Fryns syndrome – Orofaciodigital syndrome 1 – Craniofrontonasal dysplasia X-linked dominant inheritance, sometimes referred to as X-linked dominance, is a mode of genetic inheritance by which a dominant gene is carried on the X…
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Tubulin alpha-1A chain
Tubulin alpha-1A chain is a protein that in humans is encoded by the TUBA1Agene.[5][6][7] Background Tubulin alpha-1A chain is an alpha-tubulin that participates in the formation of microtubules – structural proteins that participate in cytoskeletal structure. Specifically, microtubules are composed of a heterodimer of alpha and beta-tubulin molecules. Cowan et al. demonstrated that bα1 is a primary α-tubulin of the human…
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Doublecortin
Neuronal migration protein doublecortin, also known as doublin or lissencephalin-X is a protein that in humans is encoded by the DCXgene.[5] Doublecortin (DCX) is a microtubule-associated protein expressed by neuronal precursor cells and immature neurons in embryonic and adult cortical structures. Neuronal precursor cells begin to express DCX while actively dividing, and their neuronal daughter cells continue to express DCX for 2–3 weeks as the…
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Tryptophan tryptophylquinone (TTQ) formation
Tryptophan tryptophylquinone (TTQ) is an enzyme cofactor, generated by posttranslational modification of amino acids within the protein. Methylamine dehydrogenase (MADH), an amine dehydrogenase, requires TTQ for its catalytic function. From Wikipedia where this page was last updated June 22, 2022 See also Amicyanin is a type I copper protein that plays an integral role in electron transfer. In bacteria such as Paracoccus denitrificans, amicyanin is part of a three-member redox complex, along…
