T helper cells (Th cells), also known as CD4+ cells or CD4-positive cells
The T helper cells (Th cells), also known as CD4+ cells or CD4-positive cells, are a type of T cell that play an important role in the adaptive immune system. They aid the activity of other immune cells by releasing cytokines. They are considered essential in B cellantibody class switching, breaking cross-tolerance in dendritic
CD4
In molecular biology, CD4 (cluster of differentiation 4) is a glycoprotein that serves as a co-receptor for the T-cell receptor (TCR). CD4 is found on the surface of immune cells such as T helper cells, monocytes, macrophages, and dendritic cells. It was discovered in the late 1970s and was originally known as leu-3 and
CD31
Platelet endothelial cell adhesion molecule (PECAM-1) also known as cluster of differentiation 31 (CD31) is a protein that in humans is encoded by the PECAM1gene found on chromosome17q23.3.[5][6][7][8] PECAM-1 plays a key role in removing aged neutrophils from the body. Structure PECAM-1 is a highly glycosylated protein with a mass of approximately 130
KIT (gene)
Proto-oncogene c-KIT is the gene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, CD117 (cluster of differentiation 117) or mast/stem cell growth factor receptor (SCFR).[5] Multiple transcript variants encoding different isoforms have been found for this gene.[6][7] KIT was first described by the German biochemist Axel Ullrich in
Surfeit human gene cluster
Surfeit is a human gene cluster that consists of a group of very tightly linked genes on chromosome 9 that do not share sequence similarity. Genes in this cluster are numbered 1 through 6: SURF1, SURF2, SURF3, SURF4, SURF5, and SURF6. Duhig T, Ruhrberg C, Mor O, Fried M (August 1998).
Disorders of bleeding and clotting
ClottingBy cause Clotting factors Antithrombin III deficiency Protein C deficiency Activated protein C resistance Protein S deficiency Factor V Leiden Prothrombin G20210A Platelets Sticky platelet syndrome Thrombocytosis Essential thrombocythemia DIC Purpura fulminans Antiphospholipid syndrome Clots Thrombophilia Thrombus Thrombosis Virchow's triad Trousseau sign of
Antithrombotics (thrombolytics, anticoagulants and antiplatelet drugs) (B01)
Antiplatelet drugsGlycoprotein IIb/IIIa inhibitors Abciximab Eptifibatide Orbofiban Roxifiban Sibrafiban§Tirofiban ADP receptor/P2Y12 inhibitors Thienopyridines Clopidogrel Prasugrel Ticlopidine Nucleotide/nucleoside analogs Cangrelor Elinogrel Ticagrelor Prostaglandin analogue (PGI2) Beraprost Iloprost Prostacyclin Treprostinil COX inhibitors Acetylsalicylic acid/Aspirin# Aloxiprin Carbasalate calcium Indobufen Triflusal Thromboxane inhibitors Thromboxane synthase inhibitors Dipyridamole (+ aspirin) Picotamide Terbogrel
List of human clusters of differentiation (OR CD) MOLECULES
* = group; ** = not listed on hcdm CD1*MHC-like molecule that presents lipid moleculesCD1aCD1a (Cluster of Differentiation 1a), or T-cell surface glycoprotein CD1a, is a human protein encoded by the CD1A gene. An antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.CD1bT-cell surface
Cell membrane protein disorders (other than Cell surface receptor, enzymes, and cytoskeleton)
ArrestinOguchi disease 1MyelinPelizaeusâMerzbacher disease - DejerineâSottas disease - CharcotâMarieâTooth disease 1B, 2JPulmonary surfactantSurfactant metabolism dysfunction 1, 2Cell adhesion moleculeIgSF CAM:OFC7 - Cadherin: DSG -1Â Striate palmoplantar keratoderma 1 DSG2Â Arrhythmogenic right ventricular dysplasia 10 DSG4Â LAH1 - DSC2Â Arrhythmogenic right ventricular dysplasia 11
X-Linked Disorders
X-linked dominant inheritance X-linked dominantX-linked hypophosphatemia - Focal dermal hypoplasia - Fragile X syndrome - Aicardi syndrome - Incontinentia pigmenti - Rett syndrome - CHILD syndrome - LujanâFryns syndrome - Orofaciodigital syndrome 1 - Craniofrontonasal dysplasia X-linked dominant inheritance, sometimes referred to
Inborn error of purineâpyrimidine metabolism
Inborn errors of purineâpyrimidine metabolism are a class of inborn error of metabolism disorders specifically affecting purine metabolism and pyrimidine metabolism. An example is LeschâNyhan syndrome. Urine tests may be of use in identifying some of these disorders.[1] Purine metabolism AnabolismAdenylosuccinate lyase deficiency - Adenosine Monophosphate Deaminase Deficiency type
Cadherin-1
Cadherin-1 or Epithelial cadherin(E-cadherin), (not to be confused with the APC/C activator protein CDH1) is a protein that in humans is encoded by the CDH1gene.[5] Mutations are correlated with gastric, breast, colorectal, thyroid, and ovarian cancers. CDH1 has also been designated as CD324 (cluster of differentiation 324). It is a tumor suppressor gene.[6][7] History The
Tubulin alpha-1A chain
Tubulin alpha-1A chain is a protein that in humans is encoded by the TUBA1Agene.[5][6][7] Background Tubulin alpha-1A chain is an alpha-tubulin that participates in the formation of microtubules - structural proteins that participate in cytoskeletal structure. Specifically, microtubules are composed of a heterodimer of alpha and beta-tubulin molecules.
YAP1Â
YAP1 (yes-associated protein 1), also known as YAP or YAP65, is a protein that acts as a transcription coregulator that promotes transcription of genes involved in cellular proliferation and suppressing apoptotic genes. YAP1 is a component in the hippo signaling pathway which regulates organ size, regeneration, and tumorigenesis. YAP1 was first identified
PAFAH1B1
Platelet-activating factor acetylhydrolase IB subunit alpha is an enzyme that in humans is encoded by the PAFAH1B1gene.[5][6][7] The protein is often referred to as Lis1 and plays an important role in regulating the motor protein Dynein.[8] Function PAFAH1B1 was identified as encoding a gene that when mutated or
Doublecortin
Neuronal migration protein doublecortin, also known as doublin or lissencephalin-X is a protein that in humans is encoded by the DCXgene.[5] Doublecortin (DCX) is a microtubule-associated protein expressed by neuronal precursor cells and immature neurons in embryonic and adult cortical structures. Neuronal precursor cells begin to express DCX while actively dividing,