Pituri, aka mingkulpa, is a mixture of leaves and wood ash traditionally chewed as a stimulant (or, after extended use, a depressant) by Aboriginal Australians widely across the continent.
Leaves are gathered from any of several species of native tobacco (Nicotiana) or from at least one distinct population of the species Duboisia hopwoodii. Various species of Acaci
Brain-derived neurotrophic factor (BDNF) aka abrineurin
Brain-derived neurotrophic factor (BDNF), or abrineurin, is a protein that, in humans, is encoded by the BDNF gene. BDNF is a member of the neurotrophin family of growth
Tobacco-derived 4R-cembranoid confers neuroprotection against LPS-induced hippocampal inflammation in mice (decreases levels of pro-inflammatory cytokines; improves memory function; activates STAT3, Akt1, and CREB phosphorylation; and upregulates the mRNA levels of ORM2, GDNF, and C3) independent of the α7 nicotinic receptor
Rojas-Colón, L.A., Dash, P.K., Morales-Vías, F.A. et al. 4R-cembranoid confers neuroprotection against LPS-induced hippocampal inflammation in mice. J Neuroinflammation 18, 9
Tobacco-derived 4R-cembranoid protects neuronal cells from oxygen-glucose deprivation by modulating microglial cell activation
Fu, Hefei et al. “4R-cembranoid protects neuronal cells from oxygen-glucose deprivation by modulating microglial cell activation.” Brain research bulletin vol. 179 (2022): 74
Patent for protecting and treating organophosphate-induced neuronal injury with tobacco-derived cembranoids and analogues
Ford, Byron, Ferchmin Peter, Eterovic, Vesna, Methods and compositions for protecting and treating neuroinjury (Patent), United States Grant US-8530525-B2 Assignee: Central Un
Identification of cembratriene-4,6-diol as antitumor-promoting agent from cigarette smoke condensate
Yutaka Saito, Haruo Takizawa, Sumie Konishi, Daisuke Yoshida, Shigenobu Mizusaki, Identification of cembratriene-4,6-diol as antitumor-promoting agent from cigarette smoke condensa
Tobacco use is negatively associated with the risk of developing skin cancer, prostate cancer, multiple myeloma, endometrial carcinoma, or breast cancer (negatively associated with means less disease associated with)
Impact of tobacco smoking on the risk of developing 25 different cancers in the UK: a retrospective study of 422,010 patients followed for up to 30 years. Jacob L, Freyn M, Kalder
Evidence of the protective effect of smoking against thyroid cancer
Cigarette smoking and the risk of thyroid cancer. Kreiger N, Parkes R. Cigarette smoking and the risk of thyroid cancer. Eur J Cancer. 2000 Oct;36(15):1969-73. doi: 10.1016/s0959-8
Cigarette smoking significantly reduces risk of endometrial cancer especially among postmenopausal women
Cigarette smoking and the risk of endometrial cancer: a meta-analysis. Zhou B, Yang L, Sun Q, Cong R, Gu H, Tang N, Zhu H, Wang B. Cigarette smoking and the risk of endometrial can
Smoking is associated with a reduced risk of hypertension during pregnancy
The puzzling association between smoking and hypertension during pregnancy Zhang J, Klebanoff MA, Levine RJ, Puri M, Moyer P. The puzzling association between smoking and hypertens
Evidence that cigarette smoking is associated with lower uterine leiomyomata incidence
A prospective ultrasound study of cigarette smoking and uterine leiomyomata incidence and growth Wesselink AK, Wegienka G, Coleman CM, Geller RJ, Harmon QE, Upson K, Lovett SM, Cla
Pharmacologically, nicotine acts on cholinergic (nicotinic-specific) receptors which are depleted in AD and PD. Nicotinic receptors also interact closely with several neurotransmitters including dopamine, which is implicated in both PD and Gilles de la Tourettes’s syndrome
Does nicotine have beneficial effects in the treatment of certain diseases? Birtwistle J, Hall K. Does nicotine have beneficial effects in the treatment of certain diseases? Br J N
Three mechanisms predominate for beneficial effects of smoking: the ‘anti-estrogenic effect’ of smoking; alterations in prostaglandin production; and stimulation of nicotinic cholinergic receptors in the central nervous system
Beneficial effects of nicotine and cigarette smoking: the real, the possible and the spurious Baron JA. Beneficial effects of nicotine and cigarette smoking: the real, the possible
Smoking is beneficial against Parkinson’s, Alzheimer’s, allergic alveolitis, nausea and vomiting of pregnancy, pre-eclampsia, fibroids, carcinoma of body of uterus, ulcerative colitis, pyoderma gangrenosum, aphthous stomatitis and ulceration, pemphigus, herpes simplex and acne
Smoking can be good for you Wolf R, Orion E, Matz H, Maitra S, Rowland-Payne C. Smoking can be good for you. J Cosmet Dermatol. 2004 Apr;3(2):107-11. doi: 10.1111/j.1473-2130.2004.
Primary sclerosing cholangitis, like ulcerative colitis, is a disease of non-smokers as the odds of having PSC are significantly decreased among current and former smokers
Cigarette smoking, appendectomy, and tonsillectomy as risk factors for the development of primary sclerosing cholangitis: a case control study Mitchell SA, Thyssen M, Orchard TR, J
Smoking cessation significantly raises risk and incidence of type-2 diabetes and obstructive pulmonary disease
Study shows increased risk of diabetes after smoking cessation lasts for 12 years Yeh HC, Duncan BB, Schmidt MI, Wang NY, Brancati FL. Smoking, smoking cessation, and risk for type