đ„ Tobacco Smoke, SCNâ», and Glucuronic Acid as Dual Terrain Provocateurs
A Ritual Fire That Activates Both Salt and Sugar Filtration Tobacco smoke, long cast as villain, is reframed here as ritual fireâa biochemical and symbolic stimulant that provokes two terrain guardians: Together, they form a dual filtration systemâsalt and sugar, volatility and sweetness, defens
Salt and SCNâ» deficiency erode biochemical scaffolding that supports continence, especially in older adults
The rise of adult diapers coincides with smoking bans and the dangerous restriction of sodium in the food supply and food chain. Letâs map the terrain breach: đ§ Sodiumâs Role in Continence Sodium is essential for: In older adults, hyponatremia (low sodium) is common due to diuretics, adrenal
đ§đ§ Water Intoxication, Salt Deficiency, and the New Collapse
For decades, public health messaging has told people to cut salt and drink more water. But this combinationâespecially in people already under stress, on medications, or with underlying salt-wasting tendenciesâhas created a perfect storm of electrolyte dilution, known as hyponatremia. đč What
đ§ Obesity, Diabetes, and the PF4âCXCR4âSalt Axis
Obesity and diabetes are not just metabolic disordersâthey are systemic collapses of immune tone, vascular signaling, and cellular coordination. The PF4âCXCR4âCXCL12 axis plays a central role in these processes, and its dysfunction is both a driver and consequence of salt deficiency. đč 1. O
How sodium and SCNâ» (thiocyanate) deficiencies may underlie chronic pain
Chronic pain isnât just a symptom; itâs a signal of systemic incoherence. Letâs spiral through how sodium and SCNâ» (thiocyanate) deficiencies may underlie chronic pain, especially in spinal contexts, and how the âwarsâ on foundational nutrients â eggs, sugar, and natural protein â ma
Smokers show fewer symptoms or appear less affected by certain toxins
Some smokers show fewer symptoms or appear less affected by certain toxins â arsenic included â at doses that harm nonsmokers. This isnât protection in the traditional sense. Itâs more like biochemical compensation or adaptive masking. đ Possible Mechanisms Behind the Paradox Induced Deto
đ How Chronic Myeloid Leukemia (CML) Connects to Our SodiumâSCNâ» Framework
𧏠What Is CML? CML is a clonal stem-cell malignancy defined by the Philadelphia chromosome â a translocation between chromosomes 9 and 22 that creates the BCR-ABL1 fusion gene, which drives uncontrolled tyrosine kinase activity. This leads to excessive proliferation of myeloid cells and a casca
𧏠SCN⻠as a Filament of Resilience in CF, COVID, and Vaccine Response
By Mere & Copilot đ Introduction Cystic fibrosis (CF), COVID-19, and complications arising from vaccine responses might seem like disparate phenomena. But through a biochemical lens, they converge on shared vulnerabilities â mucus integrity, redox stability, trace mineral modulation, and im
Smoking hysteria has gripped this nation since the 1980s and the people are sicker for it
Kennedy’s dodge about healthcare as a human right during his confirmation hearing, and the entire line of questioning, reveals the intellectual bankruptcy of our nation. The smoking hysteria that’s gripped this nation since the 1980s isn’t just wrong – it’s a full-blown
Pituri, aka mingkulpa, is a mixture of leaves and wood ash traditionally chewed as a stimulant (or, after extended use, a depressant) by Aboriginal Australians widely across the continent.
Leaves are gathered from any of several species of native tobacco (Nicotiana) or from at least one distinct population of the species Duboisia hopwoodii. Various species of Acacia, Grevillea and Eucalyptus are burned to produce the ash. The term “pituri” may also refer to the plant
Brain-derived neurotrophic factor (BDNF) aka abrineurin
Brain-derived neurotrophic factor (BDNF), or abrineurin, is a protein that, in humans, is encoded by the BDNF gene. BDNF is a member of the neurotrophin family of growth factors, which are related to the canonical nerve growth factor (NGF), a family which also includes NT-3 and NT-4/N
Tobacco-derived 4R-cembranoid confers neuroprotection against LPS-induced hippocampal inflammation in mice (decreases levels of pro-inflammatory cytokines; improves memory function; activates STAT3, Akt1, and CREB phosphorylation; and upregulates the mRNA levels of ORM2, GDNF, and C3) independent of the α7 nicotinic receptor
Rojas-ColĂłn, L.A., Dash, P.K., Morales-VĂas, F.A. et al. 4R-cembranoid confers neuroprotection against LPS-induced hippocampal inflammation in mice. J Neuroinflammation 18, 95 (2021). https://doi.org/10.1186/s12974-021-02136-9 LPS: Lipopolysaccharide “4R protects the hippocampus against
Tobacco-derived 4R-cembranoid protects neuronal cells from oxygen-glucose deprivation by modulating microglial cell activation
Fu, Hefei et al. â4R-cembranoid protects neuronal cells from oxygen-glucose deprivation by modulating microglial cell activation.â Brain research bulletin vol. 179 (2022): 74-82. doi:10.1016/j.brainresbull.2021.12.007 In the search for novel compounds to treat neurodegenerative diseases, we fo
Patent for protecting and treating organophosphate-induced neuronal injury with tobacco-derived cembranoids and analogues
Ford, Byron, Ferchmin Peter, Eterovic, Vesna, Methods and compositions for protecting and treating neuroinjury (Patent), United States Grant US-8530525-B2 Assignee: Central University of the Caribbean, Morehouse School of Medicine, Status: Active, Expires 2031-05-19, Document history 2013-09-10