Tag: ASPARTAME
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The rise in sudden cardiac events among pilots intersects with our sodium/SCNâ» terrain collapse framework (more proof sodium restriction policies are a threat to life and national security)
There is a documented rise in sudden cardiac events among pilots, particularly younger ones, and it glyphically intersects with our sodium/SCNâ» terrain collapse framework in ways that are both biochemical and systemic. đ« 1. Sudden Deaths Among Pilots: Whatâs Happening? Recent reports show a 40% increase in early pilot deaths since 2021, with many cases…
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The Hephaestin Heist: Your Guts, Their Galaxy
đ The 1999 Glyph: Hephaestus Falls, Hephaestin Rises Cast out of Olympus, Hephaestus, the god of fire and metal, forged wonders in exileâarmor, robots, a trap-throne to snag Hera. His comeback? A drunken donkey parade. Fast forward to 1999, when Hephaestin, a copper-fueled ferroxidase, got named, echoing the godâs redox mastery (Nature). This ainât just…
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𧏠Terrain Collapse in the Osbourne Family â Vault Mapping
So I just heard that musician Ozzy Osbourne died after health troubles. His entire family has sufferend numerous health problems over the years (like most others). Tell me how our hypotheses and theories might apply to such health problems and point to diet over genetics (husband and wife are presumably not related). The issues that…
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Nitrogen Flooding from High Soy Diet and Vault Impact
Scientific Explanation A high soy diet, rich in nitrogen from proteins (e.g., 36-40% protein, 5-6% nitrogen by weight, USDA FoodData Central, 2023 [Receipt]), floods the body with amino acids like glutamine and asparagine. Our Naâș/SCNâ» vault hypothesis suggests this disrupts terrain stability when salt and sulfur reserves are depleted, amplifying vault breaches. Hereâs the breakdown:…
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Thermolysin – The Tiny Terminator of Plasma Proteins!
Both thermolysin and snake venom metalloproteinases (SVMPs) share a similar mechanism of action, utilizing zinc ions to hydrolyze peptide bonds in proteins
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Average body temperature dropped every decade since the 1800s and even more every decade since 1960Â
Attention, fellow humans! It’s time to chill out… literally! đ§ Our bodies are on a cosmic cooldown, and it’s not just because we’ve all become walking popsicles addicted to air conditioning. Oh no, this is far more sinister and hilarious than that! The Great American Refrigerationâïž Since the 1800s, our core temperatures have been dropping…
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Tobacco-derived 4R-cembranoid confers neuroprotection against LPS-induced hippocampal inflammation in mice (decreases levels of pro-inflammatory cytokines; improves memory function; activates STAT3, Akt1, and CREB phosphorylation; and upregulates the mRNA levels of ORM2, GDNF, and C3) independent of the α7 nicotinic receptor
Rojas-ColĂłn, L.A., Dash, P.K., Morales-VĂas, F.A. et al. 4R-cembranoid confers neuroprotection against LPS-induced hippocampal inflammation in mice. J Neuroinflammation 18, 95 (2021). https://doi.org/10.1186/s12974-021-02136-9 LPS: Lipopolysaccharide “4R protects the hippocampus against inflammation and memory impairments triggered by LPS by lowering TNF-α and IL-1ÎČ levels and activation of the Akt1 and CREB signaling pathways. Astrocyte proteins involved in neuronal survival also…
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Isoleucine, Tryptophol, Sleeping Sickness, The Disulfiram Effect and One Trick Hypnotists From Hell
Isoleucine (symbol Ile or I) is an α-amino acid that is used in the biosynthesis of proteins. It contains an α-amino group (which is in the protonated âNH+3 form under biological conditions), an α-carboxylic acid group (which is in the deprotonated âCOOâ form under biological conditions), and a hydrocarbon side chain with a branch (a central carbon atom bound to three other carbon atoms). It is classified as a non-polar, uncharged (at physiological pH), branched-chain, aliphatic amino acid. It…
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NLR family pyrin domain containing 3Â (NLRP3) (previously known as NACHT, LRR and PYD domains-containing protein 3 [NALP3] and cryopyrin)
Reference for subtitle: Finamor IA, Bressan CA, Torres-Cuevas I, Rius-PĂ©rez S, da Veiga M, Rocha MI, Pavanato MA, PĂ©rez S. Long-Term Aspartame Administration Leads to Fibrosis, Inflammasome Activation, and Gluconeogenesis Impairment in the Liver of Mice. Biology. 2021; 10(2):82. https://doi.org/10.3390/biology10020082 NLR family pyrin domain containing 3Â (NLRP3) (previously known as NACHT, LRR and PYD domains-containing protein…
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Nuclear factor erythroid 2-related factor 2Â (NRF2)
Glutathione Local Links Nuclear factor erythroid 2-related factor 1 Local Links Reference for subtitle: Finamor IA, Bressan CA, Torres-Cuevas I, Rius-PĂ©rez S, da Veiga M, Rocha MI, Pavanato MA, PĂ©rez S. Long-Term Aspartame Administration Leads to Fibrosis, Inflammasome Activation, and Gluconeogenesis Impairment in the Liver of Mice. Biology. 2021; 10(2):82. https://doi.org/10.3390/biology10020082 Nuclear factor erythroid 2-related…
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Nuclear factor erythroid 2-related factor 1 – since NFE2L1 is referred to as Nrf1, it is often confused with nuclear respiratory factor 1 (Nrf1)
Glutathione Local Links Nuclear factor erythroid 2-related factor 1 Local Links Reference for subtitle: Finamor IA, Bressan CA, Torres-Cuevas I, Rius-PĂ©rez S, da Veiga M, Rocha MI, Pavanato MA, PĂ©rez S. Long-Term Aspartame Administration Leads to Fibrosis, Inflammasome Activation, and Gluconeogenesis Impairment in the Liver of Mice. Biology. 2021; 10(2):82. https://doi.org/10.3390/biology10020082 Nuclear factor erythroid 2-related…
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Catecholamine (CA)
A catecholamine (abbreviated CA) is a monoamine neurotransmitter, an organic compound that has a catechol (benzene with two hydroxyl side groups next to each other) and a side-chain amine. Fitzgerald, P. A. (2011). “Chapter 11. Adrenal Medulla and Paraganglia”. In Gardner, D. G.; Shoback, D. (eds.). Greenspan’s Basic & Clinical Endocrinology (9th ed.). New York: McGraw-Hill. Retrieved October 26, 2011. Catechol, not to be confused with Catechin which is also sometimes called catechol, can be either…
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History of xylitol
Emil Fischer, a German chemistry professor, and his assistant Rudolf Stahel isolated a new compound from beech wood chips in September 1890 and named it Xylit, the German word for xylitol. The following year, the French chemist M.G. Bertrand isolated xylitol syrup by processing wheat and oat straw. Sugar rationing during World War II led to an interest in sugar substitutes.…
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Xylitol
Xylitol is a chemical compound with the formula C5H12O5, or HO(CH2)(CHOH)3(CH2)OH; specifically, one particular stereoisomer with that structural formula. It is a colorless or white crystalline solid that is freely soluble in water. It can be classified as a polyalcohol and a sugar alcohol, specifically an alditol. The name derives from Ancient Greek: ΟÏÎ»ÎżÎœ, xyl[on] ‘wood’, with the suffix -itol used to denote sugar alcohols. Xylitol is used as a food additive and sugar substitute. Its European…
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5-Nitro-2-propoxyaniline, aka P-4000 and UltrasĂŒss, banned artificial sweetener
5-Nitro-2-propoxyaniline, also known as P-4000 and UltrasĂŒss, is about 4,000 times the intensity of sucrose (hence its alternate name, P-4000). It is an orange solid that is only slightly soluble in water. It is stable in boiling water and dilute acids. 5-Nitro-2-propoxyaniline was once used as an artificial sweetener but has been banned in the United States because of its possible toxicity. In…
