Tag: Breast cancer

  • ADAM29: The Sperm’s Secret Weapon

    ADAM29 is the protein that’s bringing a whole new meaning to “family planning”! ADAM29 is like that mysterious friend who shows up at all the important life events but keeps their day job a secret. This protein is primarily expressed in the testis, making it a VIP member of the reproductive club45. Picture ADAM29 as…

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  • HFE H63D & VO2 max

    SMOKE EM IF YOU GOT EM The HFE H63D is a single-nucleotide polymorphism in the HFE gene (c.187C>G, rs1799945), which results in the substitution of a histidine for an aspartic acid at amino acid position 63 of the HFE protein (p.His63Asp). HFE participates in the regulation of iron absorption. Homozygous H63D variant can occasionally be the cause of hemochromatosis. It is also…

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  • Tobacco use is negatively associated with the risk of developing skin cancer, prostate cancer, multiple myeloma, endometrial carcinoma, or breast cancer (negatively associated with means less disease associated with)

    Tobacco use is negatively associated with the risk of developing skin cancer, prostate cancer, multiple myeloma, endometrial carcinoma, or breast cancer (negatively associated with means less disease associated with)

    Impact of tobacco smoking on the risk of developing 25 different cancers in the UK: a retrospective study of 422,010 patients followed for up to 30 years. Jacob L, Freyn M, Kalder M et al (2018) Impact of tobacco smoking on the risk of developing 25 different cancers in the UK: a retrospective study of…

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  • Ectodomain Shedding & Sheddases & a whole bunch of Adams

    An ectodomain is the domain of a membrane protein that extends into the extracellular space (the space outside a cell). Ectodomains are usually the parts of proteins that initiate contact with surfaces, which leads to signal transduction. A notable example of an ectodomain is the S protein, commonly known as the spike protein, of the viral particle responsible for the COVID-19 pandemic. The ectodomain region of the…

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  • Gastrin-releasing peptide aka GRP

    Gastrin-releasing peptide, also known as GRP, is a neuropeptide, a regulatory molecule that has been implicated in a number of physiological and pathophysiological processes. Most notably, GRP stimulates the release of gastrin from the G cells of the stomach. The gene from which GRP is derived encodes a number of bombesin-like peptides. Its 148-amino acid preproprotein, following cleavage of a signal peptide, is further processed to…

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  • p300-CBP coactivator family – clinical significance

    Mutations in CBP, and to a lesser extent p300, are the cause of Rubinstein-Taybi Syndrome, which is characterized by severe mental retardation. These mutations result in the loss of one copy of the gene in each cell, which reduces the amount of CBP or p300 protein by half. Some mutations lead to the production of a very…

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  • Histone acetyltransferase p300

    Histone acetyltransferase p300 also known as p300 HAT or E1A-associated protein p300 (where E1A = adenovirus early region 1A) also known as EP300 or p300 is an enzyme that, in humans, is encoded by the EP300 gene. It functions as histone acetyltransferase that regulates transcription of genes via chromatin remodeling by allowing histone proteins to wrap DNA less tightly. This enzyme plays an essential role in regulating cell growth and division, prompting cells to mature and assume specialized functions…

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  • CBP has been shown to play a role in every stage of tumor development

    CBP has been shown to play a role in every stage of tumor development

    Due to its critical role in regulation of cell proliferation, growth, migration and apoptosis, it is considered to be an oncogene, or tumor suppressor. Contrarily To date, increased CBP activity has been implicated in a variety of different malignancies including breast cancer, lung cancer, prostate cancer, colorectal cancer, acute leukemias, head and neck cancer, and many others. According to the Catalog…

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  • Cadherin-1

    Cadherin-1 or Epithelial cadherin(E-cadherin), (not to be confused with the APC/C activator protein CDH1) is a protein that in humans is encoded by the CDH1gene.[5] Mutations are correlated with gastric, breast, colorectal, thyroid, and ovarian cancers. CDH1 has also been designated as CD324 (cluster of differentiation 324). It is a tumor suppressor gene.[6][7] History The discovery of cadherin cell-cell adhesion proteins is attributed to Masatoshi Takeichi, whose experience…

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