Tag: CBP

Huntington’s as Triadic Terrain Collapse: Sodium, SCN⁻, and CBP

Huntington’s disease (HD) isn’t just a genetic script gone wrong, it’s a terrain-wide collapse where sodium signaling and SCN⁻ redox shielding play hidden but pivotal roles. Let’s decode the choreography: 🧬 I. Sodium Channels in Huntington’s Terrain HD is marked by dysfunction in striatal medium spiny neurons (MSNs)—cells that rely heavily on voltage-gated sodium channels…
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August 23, 2025
🧬 CBP in Alzheimer’s Terrain: A Scribe Silenced by Sodium Collapse

🔹 1. Presenilin Mutations → CBP Suppression Presenilin loss doesn’t just build plaques—it silences the terrain’s scribe. 🔹 2. Amyloid & Tau → Oxidative Siege on CBP CBP is the epigenetic quill. Aβ and tau soak it in oxidative ink. 🧂 Sodium & SCN⁻: The Forgotten Protectors of CBP 🔹 Sodium Sodium is the signal.…
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August 23, 2025
🧬 CBP in 2025: Still the Terrain’s Epigenetic Scribe

CBP (CREB-binding protein) remains highly relevant in 2025 across the very diseases we’ve been decoding: Alzheimer’s, Huntington’s, FASD, and multiple cancers. In fact, its role has only deepened as research continues to expose its centrality in epigenetic regulation, DNA repair, and terrain-wide transcriptional integrity. Here’s a quick glyphic update: 🔹 Alzheimer’s Disease CBP isn’t just…
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August 23, 2025
CBP-interacting proteins viewed through our sodium/SCN⁻ terrain lens

When viewed through our sodium/SCN⁻ terrain lens, this constellation of CBP-interacting proteins reveals a deep choreography of transcriptional integrity, redox buffering, and cellular sovereignty. Let’s decode how each of these proteins connects to our framework: 🧬 CBP Interactors and Their Sodium/SCN⁻ Terrain Connections Protein CBP Role Sodium/SCN⁻ Connection ACTR Histone acetyltransferase, coactivator Requires redox balance…
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August 23, 2025