Tag: Chromosome 17
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Staphylokinase (SAK) aka staphylococcal fibrinolysin or Müller’s factor
Staphylokinase (SAK; also known as staphylococcal fibrinolysin or Müller’s factor) is a protein produced by Staphylococcus aureus. It contains 136 amino acid residues and has a molecular mass of 15kDa. Synthesis of staphylokinase occurs in late exponential phase. It is similar to streptokinase. Fibrinolysin is an enzyme derived from plasma of bovine origin (plasmin) or extracted from cultures of certain bacteria. (more below) Staphylokinase is positively…
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Protein phosphorylation was first reported in 1906
Protein phosphorylation is a reversible post-translational modification of proteins in which an amino acid residue is phosphorylated by a protein kinase by the addition of a covalently bound phosphate group. Phosphorylation alters the structural conformation of a protein, causing it to become activated, deactivated, or otherwise modifying its function. Approximately 13,000 human proteins have sites that are phosphorylated. The reverse reaction of phosphorylation is called dephosphorylation, and is catalyzed by…
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PAFAH1B1
Platelet-activating factor acetylhydrolase IB subunit alpha is an enzyme that in humans is encoded by the PAFAH1B1gene.[5][6][7] The protein is often referred to as Lis1 and plays an important role in regulating the motor protein Dynein.[8] Function PAFAH1B1 was identified as encoding a gene that when mutated or lost caused the lissencephaly associated with Miller–Dieker syndrome. PAFAH1B1 encodes the non-catalytic alpha subunit of the…
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Progastrin
Progastrin is an 80-amino acid intracellular protein and the precursor of gastrin, a gastrointestinal hormone produced by G cells in the gastric antrum. Fiona M., Gribble; Frank, Reimann; Geoffrey, P. Roberts (2018). Gastrointestinal Hormones. Physiology of the Gastrointestinal Tract, Elsevier. pp. 31–70. The main function of gastrin is to regulate acid secretion. Rehfeld, Jens F.; Goetze, Jens Peter (2005). “2 The Post-Translational Phase of Gene Expression in Tumor…
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Gastrin
Gastrin is a peptide hormone that stimulates secretion of gastric acid (HCl) by the parietal cells of the stomach and aids in gastric motility. It is released by G cells in the pyloric antrum of the stomach, duodenum, and the pancreas. Gastrin binds to cholecystokinin B receptors to stimulate the release of histamines in enterochromaffin-like cells, and it induces the insertion of K+/H+ ATPase pumps into the apical membrane of parietal cells (which…
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Human placental lactogen (hPL)
Human placental lactogen (hPL), also called human chorionic somatomammotropin (HCS), is a polypeptideplacental hormone, the human form of placental lactogen (chorionic somatomammotropin). Its structure and function are similar to those of human growth hormone. It modifies the metabolic state of the mother during pregnancy to facilitate the energy supply of the fetus. hPL has anti-insulin properties. hPL is a hormone secreted by the syncytiotrophoblast during pregnancy. Like human growth hormone, hPL…
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