Omenn syndrome symptoms are very similar to those of graft-versus-host disease (GVHD) due to abnormal T cells that have a specific affinity for self antigens found in the thymus and in the periphery and limited levels of recombination with mutant RAG genes
Omenn syndrome is an autosomal recessive severe combined immunodeficiency. It is associated with hypomorphic missense mutations in immunologically relevant genes of T-cells
