Tag: Endogenous steroids
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Glucuronic acid is a uronic acid that was first isolated from urine
Glucuronic acid (from Greek γλεῦκος “wine, must” and οὖρον “urine“) is a uronic acid that was first isolated from urine (hence the name”uronic acid”). It is found in many gums such as gum arabic (approx. 18%), xanthan, and kombucha tea and is important for the metabolism of microorganisms, plants and animals. Not to be confused with Gluconic acid (Gluconic acid occurs naturally in fruit, honey, and wine. As a food additive E574, it is now known as an acidity regulator.…
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20α,22R-Dihydroxycholesterol
20α,22R-Dihydroxycholesterol, or (3β)-cholest-5-ene-3,20,22-triol is an endogenous, metabolic intermediate in the biosynthesis of the steroid hormones from cholesterol. Cholesterol ((3β)-cholest-5-en-3-ol) is hydroxylated by cholesterol side-chain cleavage enzyme (P450scc) to form 22R-hydroxycholesterol, which is subsequently hydroxylated again by P450scc to form 20α,22R-dihydroxycholesterol, and finally the bond between carbons 20 and 22 is cleaved by P450scc to form pregnenolone ((3β)-3-hydroxypregn-5-en-20-one), the precursor to the steroid hormones. CHAUDHURI AC, HARADA Y, SHIMIZU K, GUT M, DORFMAN RI (March 1962). “Biosynthesis of pregnenolone from…
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22R-Hydroxycholesterol
22R-Hydroxycholesterol, or (3β)-cholest-5-ene-3,22-diol is an endogenous, metabolic intermediate in the biosynthesis of the steroid hormones from cholesterol. Cholesterol ((3β)-cholest-5-en-3-ol) is hydroxylated by cholesterol side-chain cleavage enzyme (P450scc) to form 22R-hydroxycholesterol, which is subsequently hydroxylated again by P450scc to form 20α,22R-dihydroxycholesterol, and finally the bond between carbons 20 and 22 is cleaved by P450scc to form pregnenolone ((3β)-3-hydroxypregn-5-en-20-one), the precursor to the steroid hormones. [CHAUDHURI AC, HARADA Y, SHIMIZU K, GUT M, DORFMAN RI (March 1962). “Biosynthesis of pregnenolone…
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Pregnenolone
Not to be confused with Pregnanolone or Pregneninolone. This article is about pregnenolone as a hormone. For its use as a medication or supplement, see Pregnenolone (medication).