Tag: Huntington's
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Huntington’s as Triadic Terrain Collapse: Sodium, SCN⁻, and CBP
Huntington’s disease (HD) isn’t just a genetic script gone wrong, it’s a terrain-wide collapse where sodium signaling and SCN⁻ redox shielding play hidden but pivotal roles. Let’s decode the choreography: 🧬 I. Sodium Channels in Huntington’s Terrain HD is marked by dysfunction in striatal medium spiny neurons (MSNs)—cells that rely heavily on voltage-gated sodium channels…
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🧬 CBP in 2025: Still the Terrain’s Epigenetic Scribe
CBP (CREB-binding protein) remains highly relevant in 2025 across the very diseases we’ve been decoding: Alzheimer’s, Huntington’s, FASD, and multiple cancers. In fact, its role has only deepened as research continues to expose its centrality in epigenetic regulation, DNA repair, and terrain-wide transcriptional integrity. Here’s a quick glyphic update: 🔹 Alzheimer’s Disease CBP isn’t just…
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Clusterin (apolipoprotein J)
Clusterin (apolipoprotein J) is a 75-80 kDa disulfide-linked heterodimeric protein associated with the clearance of cellular debris and apoptosis. In humans, clusterin is encoded by the CLU gene on chromosome 8. CLU is a molecular chaperone responsible for aiding protein folding of secreted proteins, and its three isoforms have been differentially implicated in pro- or antiapoptotic processes. Through this function, CLU is involved in many diseases related to oxidative stress, including neurodegenerative diseases, cancers, inflammatory diseases, and aging. Structure The CLU gene contains…
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Diminished CBP activity and decreased neuronal histone acetylation is associated with Huntington’s Disease
Huntington’s Disease (HD) is a fatal, progressing neurodegenerative disorder that is the result of a genetic mutation in the Huntingtin gene causing synthesis of a mutated huntingtin (Htt) protein. Symptoms most frequently associated with this disease are movement disorders, including impaired motor function, behavioral modification and cognitive impairment that ultimately results in dementia. It has been observed in animal…
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PPARGC1A is also known as human accelerated region 20 (HAR20) and may have played a key role in differentiating humans from apes
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α) is a protein that in humans is encoded by the PPARGC1A gene. PPARGC1A is also known as human accelerated region 20 (HAR20). It may, therefore, have played a key role in differentiating humans from apes. PGC-1α is the master regulator of mitochondrial biogenesis. PGC-1α is also the primary regulator of liver gluconeogenesis, inducing increased gene expression for gluconeogenesis. Function PGC-1α is a super…
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Phenol injections – originally used by the Nazis as part of the Aktion T4 euthanasia program – were used as a means of individual execution by Nazi Germany during the Second World War.
The toxic effect of phenol on the central nervous system, causes sudden collapse and loss of consciousness in both humans and animals; a state of cramping precedes these symptoms because of the motor activity controlled by the central nervous system.[“Phenol”. Ullmann’s Encyclopedia of Industrial Chemistry. Vol. 25. Wiley-VCH. 2003. pp. 589–604.] Injections of phenol were used as a…