ADAM8: The Inflammatory Instigator
ADAM8 is the protein that’s stirring up trouble in your immune system! ADAM8 is like that friend who always shows up when there’s drama brewing. This protein is primarily expressed in immune cells, making it a key player in inflammatory responses. Picture ADAM8 as the bouncer of the cell
Reactive arthritis aka Reiter’s syndrome
Reportedly triggered by everything from food poisoning to bug bites to STDs to hormones (estrogen, relaxin) Mnemonic: Can't See, Can't Pee, Can't Climb a Tree
Microsomal prostaglandin E synthase-1 (mPGES-1)
Microsomal prostaglandin E synthase-1 (mPGES-1)Ā orĀ Prostaglandin E synthaseĀ is anĀ enzymeĀ that in humans is encoded by theĀ PTGESĀ gene. The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinfla
ClusterinĀ (apolipoproteinĀ J)
ClusterinĀ (apolipoproteinĀ J) is a 75-80 kDa disulfide-linked heterodimericĀ proteinĀ associated with the clearance of cellular debris andĀ apoptosis. In humans, clusterin is encoded by theĀ CLUĀ geneĀ on chromosome 8.Ā CLU is aĀ molecular chaperoneĀ responsible for aidingĀ protein foldingĀ ofĀ sec
Ectodomain Shedding & Sheddases & a whole bunch of Adams
An ectodomain is the domain of a membrane protein that extends into the extracellular space (the space outside a cell). Ectodomains are usually the parts of proteins that initiate contact with surfaces, which leads to signal transduction. A nota
OsteopontinĀ (OPN)
OsteopontinĀ (OPN), also known asĀ bone /sialoprotein IĀ (BSP-1Ā orĀ BNSP),Ā early T-lymphocyte activationĀ (ETA-1),Ā secreted phosphoprotein 1Ā (SPP1),Ā 2arĀ andĀ Rickettsia resistanceĀ (Ric),Ā is aĀ proteinĀ that in humans is encoded by theĀ SPP1Ā gene (secreted phosphoprotein 1). The murine ortho
Ceruloplasmin carries more than 95% of the total copper in healthy human plasma and in addition plays a role inĀ iron metabolism. It was first described in 1948.
CeruloplasminĀ (orĀ caeruloplasmin) is aĀ ferroxidaseĀ enzymeĀ that in humans is encoded by theĀ CPĀ gene. Ceruloplasmin is the majorĀ copper-carrying protein in the blood, and in addition plays a role inĀ iron metabolism. It was first described in 1948. Another protein,Ā hephaestin, is noted for it
Indoleamine-pyrrole 2,3-dioxygenaseĀ (IDOĀ orĀ INDO) is involved in tryptophanĀ metabolism
Indoleamine-pyrrole 2,3-dioxygenase (IDO or INDO EC 1.13.11.52) is a heme-containing enzyme physiologically expressed in a number of tissues and cells, such as the small intestine, lungs, female genital tract or placenta. In humans is
Ommochrome (visual pigment) and Kynurenine (aĀ metaboliteĀ of the amino acidĀ l-tryptophanĀ used in the production ofĀ niacin)
Ommochrome (or visual pigment) refers to several biological pigments that occur in the eyes of crustaceans and insects. The eye color is determined by the ommochromes. Ommochromes are also found in the chromatophores of cephalopods, and in&
ProstaglandinsĀ (PG)
The prostaglandins (PG) are a group of physiologically active lipid compounds called eicosanoids “Eicosanoid Synthesis and Metabolism: Prostaglandins, Thromboxanes, Leukotrienes, Lipoxins”. themedicalbiochemistrypage.org. Retrieved 2018-