Tag: Integrins
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ADAM23: The Neural Navigator
ADAM23 is the protein that’s making waves in the world of neuroscience. ADAM23 is like that friend who’s always helping you find your way around a new city. This protein is highly expressed in the central nervous system and plays a crucial role in brain development1. Picture ADAM23 as the traffic controller of the neural…
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Integrin αIIbβ3 – Glycoprotein IIb/IIIa
In medicine, glycoprotein IIb/IIIa (GPIIb/IIIa, also known as integrin αIIbβ3) is an integrin complex found on platelets. It is a receptor for fibrinogen[1] and von Willebrand factor and aids platelet activation. The complex is formed via calcium-dependent association of gpIIb and gpIIIa, a required step in normal platelet aggregation and endothelial adherence.[2][3] Platelet activation by ADP (blocked by clopidogrel) leads to the aforementioned conformational change in platelet gpIIb/IIIa receptors that induces…
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