Structure of DNA repair protein XRCC4 aka X-ray repair cross-complementing protein 4
XRCC4 protein is a TETRAMER that resembles the shape of a DUMBBELL containing two globular ends separated by a long, thin stalk. The tetramer is composed of two dimers, and each
Clusterin (apolipoprotein J)
Clusterin (apolipoprotein J) is a 75-80 kDa disulfide-linked heterodimeric protein associated with the clearance of cellular debris and apoptosis. In humans, clusterin is enco
Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen
Abstract HeLa cells contain a serine/threonine protein kinase (DNA-PK) that is strongly activated in vitro by low concentrations of double-stranded DNA (dsDNA). Activation was spec
Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. NHEJ is active in both non-dividing and proliferating cells.
Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. It is called “non-homologous” because the break ends are directly ligated
Ku is a dimeric protein complex that binds to DNA double-strand break ends and is required for the non-homologous end joining (NHEJ) pathway of DNA repair
Ku is evolutionarily conserved from bacteria to humans. The ancestral bacterial Ku is a homodimer (two copies of the same protein bound to each other).[2] Eukaryotic Ku is a he
Ku70
Ku70 is a protein that, in humans, is encoded by the XRCC6 gene.[5][6] Function Together, Ku70 and Ku80 make up the Ku heterodimer, which bi
Ku80
Ku80 is a protein that, in humans, is encoded by the XRCC5 gene.[5] Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to&