Tag: Lymphocytes
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Chalone Rangers: The Tissue-Specific Mitotic Inhibitors You Never Knew You Needed
Chalones are the unsung heroes of cellular crowd control. These tissue-specific, water-soluble substances are like the bouncers of your body, standing at the gates of mitosis with their arms crossed, saying, “Not tonight, buddy.” They’re the biochemical equivalent of that one friend who knows when to call it a night before things get out of…
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ADAM28: The Lymphocyte’s Little Helper
ADAM28 is the protein that’s bringing a whole new meaning to “immune system support”! ADAM28 is like that friend who’s always hanging out with the cool kids – in this case, the lymphocytes. This protein is exclusively expressed by lymphocytes, making it the VIP member of the immune system club. Picture ADAM28 as the backstage…
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The molecular mayhem of immunogens, haptens, carriers and adjuvants
First up, the immunogen: the molecular maestro of the immune system, orchestrating a symphony of B-cells and T-cells like a conductor with a grudge. These substances don’t just knock politely on the immune system’s door—they kick it down with the force of a battering ram. Immunogens are a subset of antigens (because “antibody-generating” wasn’t obvious enough)…
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Indoleamine-pyrrole 2,3-dioxygenase (IDO or INDO) is involved in tryptophan metabolism
Indoleamine-pyrrole 2,3-dioxygenase (IDO or INDO EC 1.13.11.52) is a heme-containing enzyme physiologically expressed in a number of tissues and cells, such as the small intestine, lungs, female genital tract or placenta. In humans is encoded by the IDO1 gene. IDO is involved in tryptophan metabolism. It is one of three enzymes that catalyze the first and rate-limiting step in the kynurenine pathway, the O2-dependent oxidation of L-tryptophan to N-formylkynurenine, the others being indolamine-2,3-dioxygenase 2 (IDO2) and tryptophan 2,3-dioxygenase…
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It is difficult to choose a few quotes from this halloweenish medical article from 1974
The 'Bottleneck In Bodies' Has Created The Agonizing Ethical Dilemma: Who Shall Live and Who Shall Die? By David Dempsey, Oct. 13, 1974