Tag: Melanocytes
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APUD cells (DNES cells)
APUD cells (DNES cells) constitute a group of apparently unrelated endocrine cells, which were named by the scientist A.G.E. Pearse, who developed the APUD concept in the 1960s based on calcitonin-secreting parafollicular C cells of dog thyroid. These cells share the common function of secreting a low molecular weight polypeptide hormone. There are several different types which secrete the hormones secretin, cholecystokinin and several others.…
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Microphthalmia-associated transcription factor aka class E basic helix-loop-helix protein 32 or bHLHe32
Microphthalmia-associated transcription factor also known as class E basic helix-loop-helix protein 32 or bHLHe32 is a protein that in humans is encoded by the MITF gene. AKA MITF, CMM8, MI, WS2, WS2A, bHLHe32, microphthalmia-associated transcription factor, melanogenesis associated transcription factor, COMMAD, melanocyte inducing transcription factor, MITF-A RNA expression pattern Human Mouse (ortholog) Top expressed inretinal pigment epitheliumright ventriclemyocardiumvastus lateralis muscledeltoid muscleurethrarenal medullavisceral pleurasaphenous veinsecondary oocyte Top…
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Pro-opiomelanocortin (POMC)
Pro-opiomelanocortin (POMC) is a precursor polypeptide with 241 amino acid residues. POMC is synthesized in corticotrophs of the anterior pituitary from the 267-amino-acid-long polypeptide precursor pre-pro-opiomelanocortin (pre-POMC), by the removal of a 26-amino-acid-long signal peptide sequence during translation. “pro-opiomelanocortin preproprotein [Homo sapiens] – Protein – NCBI”. www.ncbi.nlm.nih.gov. Retrieved 30 December 2020. POMC is part of the central melanocortin system. Function POMC is cut (cleaved) to give rise to multiple peptide hormones. Each of these peptides is packaged…
