Tag: Pregnancy
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Sodium and thiocyanate suppression causes infertility (and most every other health problem)
Sodium is absolutely essential to life, reproduction, and systemic coherence. Briefly: Without sodium, life collapses into incoherence. Itâs not seasoningâitâs signal. But you may not know the same is true for thiocyanate, a kind of mammal marker required for life and proper functioning and reproduction. Sodium deficiency represses thiocyanate. The best workaround for humans may…
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Echoes in the Womb: What Whale Strandings Reveal About Prenatal Sonic Terrain
đ Introduction: Sonic Collapse in the Deep Whale strandings are among the most haunting glyphs of ecological collapse. These majestic mammals, guided by sodium gradients and acoustic navigation, suddenly lose coherenceâbeaching themselves in mass disorientation. Investigations often point to sonar, offshore wind, and synthetic mimicry as culprits. But beneath the surface lies a deeper question:…
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Do Whale Strandings Have Implications for Prenatal Sonograms?
Yesâand this is a glyphic leap worth making. đč Sonic Terrain Disruption đč Prenatal Sonograms: A Parallel? đč Terrain-Based Concerns đč Glyphic Parallel Sonic Exposure Terrain Impact in Whales Terrain Impact in Fetuses Sonar / wind sonar Disorientation, strandings Possible neural modulation Acoustic field Sodium gradient collapse Electrical coherence risk Synthetic mimicry SCNâ» transport inhibition…
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Snake Venom: The Hormone Hijacker đ
Imagine a villainous mastermind that can infiltrate your body’s hormonal headquarters, manipulating the delicate balance of estrogen and other hormones. Welcome to the world of snake venom, where the stakes are high and the effects are unpredictable. Estrogen’s Uninvited Guest: When Snake Venom Crashes the Hormone Hoedown Prepare for the most bizarre gatecrasher at the…
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envenomation during pregnancy is associated with increased risks including miscarriage
Several studies and case reports indicate that snake envenomation during pregnancy is associated with an increased risk of adverse outcomes, including miscarriage: Spontaneous abortions: Multiple studies report high rates of spontaneous abortions following venomous snake bites in pregnant women. One study found that nearly 30% of envenomated pregnant mothers experienced a spontaneous abortion. Fetal loss:…
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The neonatal fragment crystallizable (Fc) receptor (also FcRn, IgG receptor FcRn large subunit p51, or Brambell receptor) is a protein that in humans is encoded by the FCGRT gene
It is an IgG Fc receptor which is similar in structure to the MHC class I molecule and also associates with beta-2-microglobulin. In rodents, FcRn was originally identified as the receptor that transports maternal immunoglobulin G (IgG) from mother to neonatal offspring via mother’s milk, leading to its name as the neonatal Fc receptor. In humans, FcRn is present in the placenta where…
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Elevated alpha-fetoprotein
Elevated alpha-fetoprotein refers to a state where alpha-fetoprotein levels are outside of the reference range. There are two categories of AFP tests: tests performed on serum (blood plasma), and tests performed on amniotic fluid. Tests performed on serum are further categorized by the reason for performing the test: maternal serum, adult tumor marker, and pediatric tumor marker. Serum The standard…
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Smoking is associated with a reduced risk of hypertension during pregnancy
The puzzling association between smoking and hypertension during pregnancy Zhang J, Klebanoff MA, Levine RJ, Puri M, Moyer P. The puzzling association between smoking and hypertension during pregnancy. Am J Obstet Gynecol. 1999 Dec;181(6):1407-13. doi: 10.1016/s0002-9378(99)70384-4. PMID: 10601921.
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Microsomal prostaglandin E synthase-1 (mPGES-1)
Microsomal prostaglandin E synthase-1 (mPGES-1) or Prostaglandin E synthase is an enzyme that in humans is encoded by the PTGES gene. The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in…
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Thunderstones in European Folklore
In Scandinavia thunderstones were frequently worshiped as family gods who kept off spells and witchcraft. Beer was poured over them as an offering, and they were sometimes anointed with butter. In Switzerland the owner of a thunderstone whirls it, on the end of a thong, three times around his head, and throws it at the door of his dwelling at the approach of…
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Intrauterine Exposure to Paracetamol and Aniline Impairs Female Reproductive Development by Reducing Follicle Reserves and Fertility
Studies report that fetal exposure to paracetamol/acetaminophen by maternal consumption can interfere with male reproductive development. Moreover, recent biomonitoring data report widespread presence of paracetamol in German and Danish populations, suggesting exposure via secondary (nonpharmaceutical) sources, such as metabolic conversion from the ubiquitous industrial compound aniline. In this study, we investigated the extent to which…
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Tovey LA, Lathe GH. Caeruloplasmin and green plasma in women taking oral contraceptives, in pregnant women, and in patients with rheumatoid arthritis. Lancet. 1968 Sep 14;2(7568):596-600. PMID: 4175158.
ABSTRACT: Of blood donations reaching the Leeds Regional Blood Transfusion Laboratory about 1% have green plasma. Most of these come from women taking oral contraceptives, who constitute about 6% of the blood-donor population. The three conditions in which green plasma is found all have elevated amounts of the blue plasma-protein, cĂŠruloplasmin. A reduction in yellow…
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Ceruloplasmin carries more than 95% of the total copper in healthy human plasma and in addition plays a role in iron metabolism. It was first described in 1948.
Ceruloplasmin (or caeruloplasmin) is a ferroxidase enzyme that in humans is encoded by the CP gene. Ceruloplasmin is the major copper-carrying protein in the blood, and in addition plays a role in iron metabolism. It was first described in 1948. Another protein, hephaestin, is noted for its homology to ceruloplasmin, and also participates in iron and probably copper metabolism. Function Ceruloplasmin (CP) is an enzyme (EC 1.16.3.1) synthesized…
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CBP and p300 are critical for normal embryonic development
Mouse models CBP and p300 are critical for normal embryonic development, as mice completely lacking either CBP or p300 protein, die at an early embryonic stage. In addition, mice which lack one functional copy (allele) of both the CBP and p300 genes (i.e. are heterozygous for both CBP and p300) and thus have half of the normal amount…
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Metoclopramide, Paracetamol/metoclopramide, Witch’s Milk, Lactating Men and Homicidal Maniacs?
Metoclopramide is a medication used for stomach and esophageal problems. It is commonly used to treat and prevent nausea and vomiting, to help with emptying of the stomach in people with delayed stomach emptying, and to help with gastroesophageal reflux disease. It is also used to treat migraine headaches. Common side effects include: feeling tired, diarrhea, and feeling restless. More serious side effects include: movement disorder like tardive dyskinesia, a condition called neuroleptic malignant…
