Tag: Stroke
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š§¬ Disease Table with Low Sodium Connection
Disease / Condition Incidence Since 1977 Low Sodium Connection Obesity š” š” ā Chronic sodium deficiency disrupts leptin and aldosterone signaling, impairing satiety and promoting fat retention. SCNā» depletion (repressed due to sodium deficiency) compounds this by weakening mitochondrial oxidation and terrain resilience. Type 2 Diabetes š” š” ā Low sodium destabilizes insulin signaling and renal glucose…
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HFE H63D & VO2Ā max
SMOKE EM IF YOU GOT EM TheĀ HFE H63DĀ is aĀ single-nucleotide polymorphismĀ in theĀ HFE geneĀ (c.187C>G, rs1799945), which results in the substitution of a histidine for an aspartic acid at amino acid position 63 of the HFE protein (p.His63Asp). HFE participates in the regulation of iron absorption. Homozygous H63D variant can occasionally be the cause ofĀ hemochromatosis. It is also…
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Deficiency of Adenosine deaminase 2Ā (DADA2)
Deficiency of Adenosine deaminase 2Ā (DADA2) is aĀ monogenic diseaseĀ associated withĀ systemic inflammationĀ andĀ vasculopathyĀ that affects a wide variety of organs in different patients. As a result, it is hard to characterize a patient with this disorder. Manifestations of the disease include but are not limited to recurrent fever, livedoid rash (reticularisĀ orĀ racemosa), variousĀ cytopenias,Ā stroke,Ā immunodeficiency, andĀ bone marrow failure. Symptoms often onset during…
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Phosphopyruvate hydratase, aka enolase, is a metalloenzyme that catalyses the conversion of 2-phosphoglycerate (2-PG) to phosphoenolpyruvate (PEP), the ninth and penultimate step of glycolysis
Phosphopyruvate hydratase, usually known as enolase, is a metalloenzyme (EC 4.2.1.11) that catalyses the conversion of 2-phosphoglycerate (2-PG) to phosphoenolpyruvate (PEP), the ninth and penultimate step of glycolysis. The chemical reaction is:2-phospho-D-glycerate ā phosphoenolpyruvate + H2O Phosphopyruvate hydratase belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme is 2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming). The reaction is reversible, depending on environmental concentrations of…
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What Is Nitrophenol? (besides something mentioned in āScientific Opinion on the reāevaluation of aspartame as a food additiveā)
Nitrophenols are compounds of the formula HOC6H5āx(NO2)x. The conjugate bases are called nitrophenolates. Nitrophenols are more acidic than phenol itself. Wikipedia Mono-nitrophenols with the formula HOC6H4NO2. Three isomeric nitrophenols exist: o-Nitrophenol (2-nitrophenol; OH and NO2 groups are neighboring; CAS number: 88-75-5), a yellow crystalline solid (m.p. 46 Ā°C). m-Nitrophenol (3-nitrophenol, CAS number: 554-84-7), a yellow solid (m.p. 97 Ā°C) and precursor to the…
