HFE H63D & VO2Ā max
SMOKE EM IF YOU GOT EM TheĀ HFE H63DĀ is aĀ single-nucleotide polymorphismĀ in theĀ HFE geneĀ (c.187C>G, rs1799945), which results in the substitution of a histidine for an aspartic acid at amino acid position 63 of the HFE protein (p.His63Asp). HFE participates in the regulation of iron absorption.
Transferrin binding and PH
Transferrin binding to transferrin receptors reduces its affinity for iron. Two pathways can occur once endocytosedādegradation or recycling pathways.Ā The degradation pathway is where the dissociation of ferric ions from transferrin occurs from an early and late endosome. Iron can now be utilized
DMT1 aka DCT1 and NRAMP2
Natural resistance-associated macrophage protein 2 (NRAMP 2), also known as divalent metal transporter 1 (DMT1) and divalent cation transporter 1 (DCT1), is a protein that in humans is encoded by the SLC11A2 (solute carrier family 11, member 2)
Transferrins
Transferrins are not limited to only binding to iron but also to different metal ions.