December 31, 2023

Ectodomain Shedding & Sheddases & a whole bunch of Adams

An ectodomain is the domain of a membrane protein that extends into the extracellular space (the space outside a cell). Ectodomains are usually the parts of proteins that initiate contact with surfaces, which leads to signal transduction. A notable example of… Read more.

Dec 31, 2023

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Blood, CREATURES, Metals
The NACHT domain consists of seven distinct conserved motifs, including the ATP/GTPase specific P-loop, the Mg2+-binding site (Walker A and B motifs, respectively) and five more specific motifs

The NACHT domain is an evolutionarily conserved protein domain. This NTPase domain is found in apoptosis proteins as well as those involved in MHC transcription. Its name reflects some of the proteins that contain it: NAIP (NLP family apoptosis inhibitor protein), CIITA (that is, C2TA or MHC… Read more.

Dec 31, 2023

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Aminosaurs, Bugs, Complement, Proteins, Silkworm, Sticks and Stones