Patent for protecting and treating organophosphate-induced neuronal injury with tobacco-derived cembranoids and analogues

Ford, Byron, Ferchmin Peter, Eterovic, Vesna, Methods and compositions for protecting and treating neuroinjury (Patent), United States Grant US-8530525-B2 Assignee: Central University of the Caribbean, Morehouse School of Medicine, Status: Active, Expires 2031-05-19, Document history 2013-09-10 Publication date, 2010-07-01 Filing date, 2009-07-14 Priority date. Funded by National Institute of Neurological Disorders and Stroke, National Institute on Minority Health and Health Disparities

Abstract A method and composition for protecting and/or treating neuroinjury are disclosed. In one aspect, the present application discloses a method for protecting and/or treating a subject from organophosphate-induced neuronal injury. The method comprises administering to a subject an effective amount of 4R cembranoid, 4S cembranoid or a cembranoid analogue. In another aspect, the application discloses neuroprotective pharmaceutical compositions for protecting and/or treating a subject from organophosphate-induced neuronal injury. A kit for protecting and treating a subject from organophosphate-induced neurodamage is also disclosed.