Cancer
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Ascus (bethesda System)
The Bethesda system聽(TBS), officially called聽The Bethesda System for Reporting Cervical Cytology, is a system for reporting聽cervical聽or vaginal聽cytologic聽diagnoses,[1]聽used for reporting聽Pap smear聽results. It was introduced in 1988[2]聽and revised in 1991,[3]聽2001,[1][4][5]聽and 2014.[6]聽The name… Read more.
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p300-CBP coactivator family – clinical significance
Mutations in CBP, and to a lesser extent p300, are the cause of聽Rubinstein-Taybi Syndrome,聽which is characterized by severe mental retardation. These mutations result in the loss of one copy of… Read more.
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Histone acetyltransferase p300
Histone acetyltransferase p300聽also known as聽p300 HAT聽or聽E1A-associated protein p300聽(where E1A =聽adenovirus early region 1A) also known as聽EP300聽or聽p300聽is an聽enzyme聽that, in humans, is encoded by the聽EP300聽gene.聽It functions as聽histone acetyltransferase聽that regulates transcription of genes… Read more.
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CBP has been shown to play a role in every stage of tumor development
Due to its critical role in regulation of cell proliferation, growth, migration and apoptosis, it is considered to be an聽oncogene, or tumor suppressor.聽Contrarily To date, increased CBP activity has been… Read more.
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CBP has intrinsic聽acetyltransferase聽functions
Cyclic adenosine monophosphate聽Response聽Element聽Binding protein聽Binding聽Protein (CREB-binding protein), also known as聽CREBBP聽or聽CBP聽or聽KAT3A, is a聽coactivator聽encoded by the聽CREBBP聽gene聽in humans, located on chromosome 16p13.3. CBP has intrinsic聽acetyltransferase聽functions; it is able to add acetyl groups to both… Read more.
