šš„ āThe Milkmaidās Covenantā: Linking Cowpox Immunity to SCNā» in Raw Milk
In 1796, Edward Jenner famously inoculated eight-year-old James Phipps with material from the cowpox lesions of dairymaid Sarah Nelmes. Phipps did not contract smallpox when later exposed, confirming Jennerās hypothesis: cowpox conferred immunity to smallpox. But what if the milkmaidās immunity
TheĀ neonatal fragment crystallizable (Fc) receptorĀ (alsoĀ FcRn,Ā IgG receptor FcRn large subunit p51, orĀ BrambellĀ receptor) is aĀ proteinĀ that in humans is encoded by theĀ FCGRTĀ gene
It is anĀ IgG Fc receptorĀ which is similar in structure to theĀ MHC class IĀ molecule and also associates withĀ beta-2-microglobulin.Ā In rodents, FcRn was originally identified as the receptor that transports maternal immunoglobulin G (IgG) from mother to neonatal offspring viaĀ mother’s mil